[The morphofunctional characteristics of the macrophages during reparative myogenesis under the action of immunomodulators]. / Morfofunktsional'naia kharakteristika makrofagov v protsesse reparativnogo miogeneza pri deistvii immunomoduliatorov.

The electron transmission microscopy was used for studying the ultrastructure of macrophages involved in the reparative regeneration of skeletal muscles of Wistar rats after a mechanical injury. Two morphofunctional types were established with special reference to ultrastructural features of the macrophages and morphometrical characteristics of organelles of these cells. The first type includes macrophages with a strong lysosomal apparatus and great amount of phagosomes containing a muscular dendritis. They are responsible for phagocytic functions and facilitate debridement of the wound from tissue disintegration products. The second (secretory) type is the cells with the developed granular endoplasmic reticulum which can exert a regulatory influence on processes of reparative regeneration of the skeletal muscles. Immunomodulators influence the level of the development of organelles of both types of macrophages which facilitates the earlier development of regeneration processes and wound healing.

[Cell-differon organization of the tissues and the problem of wound healing]. / Kletochno-differonnaia organizatsiia tkanei i problema zazhivleniia ran.

Problems on correlation of processes of normal histogenesis and those of physiological and reparative regeneration are discussed. A special attention is paid to the cellular-differon organization of tissue and its significance for understanding cellular mechanisms and ultrastructural bases in tissue regeneration after lesions and use of biostimulators of various origin. Certain peculiarities have been revealed in changes of intra- and interdifferon interrelations of cells in various tissues at regenerative histogenesis. The biostimulators applied differently change duration and manifestation of its stages, that is they influence the internal structure of the process and the cellular-tissue composition of the regenerate.