ABSTRACT
Prevalence of Lewis antigens and phenotypes has been investigated in 60 healthy donors and 74 patients with ischemic heart disease. It was found that phenotype Le(a-b-) marks high risk and phenotype Le(a-b+) is a resistance marker for development of ischemic heart disease. It would be valid to elucidate relationships between Lewis system and pathogenesis of internal diseases.
Subject(s)
Lewis Blood Group Antigens/blood , Myocardial Ischemia/blood , Adult , Biomarkers/blood , Blood Donors/statistics & numerical data , Chi-Square Distribution , Female , Humans , Male , Middle Aged , Phenotype , Risk Factors , Russia , Urban Population/statistics & numerical dataABSTRACT
An analysis of clinico-laboratory examinations of 60 patients with a suspected contusion of the heart in an isolated and associated trauma of the chest and experimental investigations on 46 dogs have shown that the closed trauma of the chest with a contusion of the heart is accompanied by disorders of the contractive function of the myocardium and hemodynamics which contributes to the development of cardiogenic shock.