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1.
Phys Med Biol ; 62(9): 3619-3638, 2017 05 07.
Article in English | MEDLINE | ID: mdl-28192280

ABSTRACT

Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are potentially superior to the traditional centroid method, require accurate knowledge of the spatial response of each photomultiplier. Using both Monte Carlo simulations and experimental data obtained with a camera prototype, we show that the spatial response of all photomultipliers (light response functions) can be parameterized with axially symmetric functions obtained iteratively from flood field irradiation data. The study was performed with a camera prototype equipped with a 30 × 30 × 2 mm3 LYSO crystal and an 8 × 8 array of SiPMs for 140 keV gamma rays. The simulations demonstrate that the images, reconstructed with the maximum likelihood method using the response obtained with the iterative approach, exhibit only minor distortions: the average difference between the reconstructed and the true positions in X and Y directions does not exceed 0.2 mm in the central area of 22 × 22 mm2 and 0.4 mm at the periphery of the camera. A similar level of image distortions is shown experimentally with the camera prototype.


Subject(s)
Gamma Cameras , Photons , Radionuclide Imaging/methods , Gamma Rays , Likelihood Functions , Monte Carlo Method , Radionuclide Imaging/instrumentation
2.
Phys Med Biol ; 60(10): 4169-84, 2015 May 21.
Article in English | MEDLINE | ID: mdl-25951792

ABSTRACT

Statistical event reconstruction techniques can give better results for gamma cameras than the traditional centroid method. However, implementation of such techniques requires detailed knowledge of the photomultiplier tube light-response functions. Here we describe an iterative method which allows one to obtain the response functions from flood irradiation data without imposing strict requirements on the spatial uniformity of the event distribution. A successful application of the method for medical gamma cameras is demonstrated using both simulated and experimental data. An implementation of the iterative reconstruction technique capable of operating in real time is presented. We show that this technique can also be used for monitoring photomultiplier gain variations.


Subject(s)
Algorithms , Amplifiers, Electronic , Gamma Cameras , Radiometry/instrumentation
3.
Appl Radiat Isot ; 68(4-5): 643-6, 2010.
Article in English | MEDLINE | ID: mdl-20096595

ABSTRACT

In 2002, an innovative neutron time-of-flight facility started operation at CERN: n_TOF. The main characteristics that make the new facility unique are the high instantaneous neutron flux, high resolution and wide energy range. Combined with state-of-the-art detectors and data acquisition system, these features have allowed to collect high accuracy neutron cross-section data on a variety of isotopes, many of which radioactive, of interest for Nuclear Astrophysics and for applications to advanced reactor technologies. A review of the most important results on capture and fission reactions obtained so far at n_TOF is presented, together with plans for new measurements related to nuclear industry.


Subject(s)
Neutron Capture Therapy/instrumentation , Neutron Capture Therapy/methods , Nuclear Reactors , Equipment Design , Equipment Failure Analysis , Neutrons , Reproducibility of Results , Sensitivity and Specificity
4.
Phys Rev Lett ; 103(15): 151302, 2009 Oct 09.
Article in English | MEDLINE | ID: mdl-19905617

ABSTRACT

We present new experimental constraints on the WIMP-nucleon spin-dependent elastic cross sections using data from the first science run of ZEPLIN-III, a two-phase xenon experiment searching for galactic dark matter weakly interacting massive particles based at the Boulby mine. Analysis of approximately 450 kg x days fiducial exposure allow us to place a 90%-confidence upper limit on the pure WIMP-neutron cross section of sigma(n)=1.9x10(-2) pb at 55 GeV/c(2) WIMP mass. Recent calculations of the nuclear spin structure based on the Bonn charge-dependent nucleon-nucleon potential were used for the odd-neutron isotopes 129Xe and 131Xe. These indicate that the sensitivity of xenon targets to the spin-dependent WIMP-proton interaction could be much lower than implied by previous calculations, whereas the WIMP-neutron sensitivity is impaired only by a factor of approximately 2.

5.
Phys Rev Lett ; 93(16): 161103, 2004 Oct 15.
Article in English | MEDLINE | ID: mdl-15524972

ABSTRACT

The151Sm(n,gamma)152Sm cross section has been measured at the spallation neutron facility n_TOF at CERN in the energy range from 1 eV to 1 MeV. The new facility combines excellent resolution in neutron time-of-flight, low repetition rates, and an unsurpassed instantaneous luminosity, resulting in rather favorable signal/background ratios. The 151Sm cross section is of importance for characterizing neutron capture nucleosynthesis in asymptotic giant branch stars. At a thermal energy of kT=30 keV the Maxwellian averaged cross section of this unstable isotope (t(1/2)=93 yr) was determined to be 3100+/-160 mb, significantly larger than theoretical predictions.

7.
Biofizika ; 29(2): 212-5, 1984.
Article in Russian | MEDLINE | ID: mdl-6722189

ABSTRACT

Dipole structure and mobility of dipoles in helical regions of collagen macromolecules were analysed. The mechanism of shearstressed piezoelectric polarization was proposed. On the proposed model quantitative calculations were carried out; the obtained value of coefficient e14 for oriented artificial collagen film comes to an agreement with experimental meaning.


Subject(s)
Collagen , Models, Theoretical , Electricity , Macromolecular Substances , Protein Conformation
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