ABSTRACT
In a pilot double-blind, randomized, prospective controlled study the effectiveness and safety of 0.3% netilmicin ophthalmic solution were compared with those of 0.3% tobramycin in treating external bacterial ocular infections in 45 eligible patients. The treatment with both study medications resulted in a significant (p < 0.001, Wilcoxon test) reduction in the mean cumulative score of the signs and symptoms. However, no statistically significant differences were observed between the two groups. The clinical improvement rate was almost complete with either antibiotics. There was a statistically positive trend in the netilmicin group with regard to the microbiological improvement that was achieved in (87% of the netilmicin patients) compared with 77% of the tobramycin patients (77%). Antibiotic sensitivity revealed that 84% of the organisms isolated were sensitive to netilmicin whereas only 64% of them were sensitive to tobramycin. Only minor adverse events occurred in patients treated with either netilmicin or tobramycin. In conclusion, this study demonstrates that netilmicin is a promising new antibiotic for treating external ocular infections.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Conjunctivitis, Bacterial/drug therapy , Gentamicins/therapeutic use , Netilmicin/therapeutic use , Staphylococcal Infections/drug therapy , Tobramycin/therapeutic use , Administration, Topical , Adult , Conjunctivitis, Bacterial/microbiology , Double-Blind Method , Drug Resistance, Microbial , Female , Humans , Male , Microbial Sensitivity Tests , Staphylococcal Infections/microbiology , Staphylococcus aureus/drug effects , Treatment OutcomeABSTRACT
The cronical ischemical ophthalmopathy represents an ocular clinical syndrome with well-defined clinical particularities. It is the effect of the decrease of the perfussion pressure at ACR level, during a long time period, caused by the stenosis of the aortic arch and his main branches. The paper presents a clinical observation of cronical ischemical ophthalmopathy having in ethiology the unspecific aortitis or the Takayasu-Onishi diasease. It is extensively discussed the ocular clinical syndrome and the particularities of the Takayasu-Onishi disease.
Subject(s)
Ischemia/etiology , Retinal Artery , Takayasu Arteritis/complications , Chronic Disease , Diagnosis, Differential , Humans , Ischemia/diagnosis , Male , Middle Aged , Prognosis , Retinal Diseases/diagnosis , Retinal Diseases/etiology , Syndrome , Takayasu Arteritis/diagnosisSubject(s)
Adjuvants, Immunologic/therapeutic use , Antiviral Agents/therapeutic use , Herpesviridae Infections/drug therapy , Papillomaviridae , Papillomavirus Infections/drug therapy , Tumor Virus Infections/drug therapy , Adolescent , Adult , Child , Child, Preschool , Drug Therapy, Combination , Female , Humans , Infant , Male , Middle AgedABSTRACT
A group of 16 patients with ophthalmic zona zoster received antiviral and immunostimulating treatment with Romanian specific products. Results were spectacular. The problem of the identity of the varicella and zoster viruses is discussed.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Antiviral Agents/therapeutic use , Herpes Zoster Ophthalmicus/drug therapy , Adolescent , Adult , Antigens, Viral/therapeutic use , Arachidonic Acid/therapeutic use , Biguanides , Corynebacterium , Drug Evaluation , Drug Therapy, Combination , Humans , Middle Aged , Morpholines/therapeutic use , Propionibacterium acnes/immunology , Time Factors , Vitamin A/therapeutic useABSTRACT
A group of 16 patients with ophthalmic zona zoster received antiviral and immunostimulative treatment with Romanian specific products. Results were spectacular. The problem of the identity of the varicella and zoster viruses is discussed.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Antiviral Agents/therapeutic use , Herpes Zoster Ophthalmicus/therapy , Adolescent , Adult , Aged , Antigens, Viral/therapeutic use , Arachidonic Acid/therapeutic use , Biguanides , Child , Child, Preschool , Combined Modality Therapy , Corynebacterium , Drug Therapy, Combination , Follow-Up Studies , Herpes Zoster Ophthalmicus/drug therapy , Humans , Infant , Middle Aged , Morpholines/therapeutic use , Recurrence , Treatment Outcome , Vitamin A/therapeutic useABSTRACT
A group of 113 patients with herpetic keratitis who were administered besides the classical therapy (local and general) immunologic and antiviral treatments was studied. The following Romanian non-toxic preparations were used: "SRE Immunostimulent", "Moroxidin" chlorhydrate and "Antiherpin". The control group including 120 patients received a classical treatment and the first signs of recovery appeared after 30 days; in 32% of the patients recurrences, were recorded during the first year. The recovery of the patients included in the experimental lot (113) consisted in the disappearance of congestive phenomena after 3-4 days; recurrences occurred in 14% of the patients after 1, 2 or even 4 years, especially in those who received an incomplete treatment.
Subject(s)
Antiviral Agents/therapeutic use , Immunotherapy , Keratitis, Herpetic/therapy , Adjuvants, Immunologic/therapeutic use , Adult , Antigens, Viral/therapeutic use , Biguanides , Combined Modality Therapy , Drug Evaluation , Female , Humans , Male , Middle Aged , Morpholines/therapeutic use , Recurrence , Remission Induction , Vaccinia virus/immunology , Viral Vaccines/therapeutic useABSTRACT
The investigation of a number of 286 patients having disorders of binocular seeing shows a very frequent association of these to spasmophilia, especially for persons of feminine sex during their third or fourth decades of life. The medicamentous treatment of spasmophilia has ameliorated the disturbing binocular seeings, which had appeared again after stopping the treatment for a long time. The authors recommend the cover-test end the examination using Maddox's experiment for tracing rapidly out the binocular seeing disturbings. In order to stimulate the movements of the ocular globe in an reverse sense to the deviation formed by the oculomotor existed lack of poise, it had been used the prescription of classes with prisms assembled conversely to the classic rules, having the indication of wearing them for 3-4 hours a day.
Subject(s)
Calcium Metabolism Disorders/complications , Eye Diseases/etiology , Phosphorus Metabolism Disorders/complications , Adolescent , Adult , Calcium/therapeutic use , Calcium Metabolism Disorders/diagnosis , Calcium Metabolism Disorders/drug therapy , Child , Drug Therapy, Combination , Ergocalciferols/therapeutic use , Eye Diseases/diagnosis , Eye Diseases/drug therapy , Female , Humans , Male , Middle Aged , Phosphorus Metabolism Disorders/diagnosis , Phosphorus Metabolism Disorders/drug therapy , Tetany/complications , Tetany/diagnosis , Tetany/drug therapy , Vision Disorders/diagnosis , Vision Disorders/drug therapy , Vision Disorders/etiology , Vision, BinocularABSTRACT
The paper reports on a study of 32 cases of new-born children who presented various ocular congenital anomalies, studied by karyotype. The genetic investigation was performed for identifying the risk factors.
