1.
Chem Pharm Bull (Tokyo)
; 60(1): 104-9, 2012.
Article
in English
| MEDLINE
| ID: mdl-22223381
ABSTRACT
A green and efficient preparation method for the amino bisphosphonates is accomplished by simple mixing and stirring of diethylphosphite, triethylorthoformate and various amines in the presence of amberlyst-15 as catalyst at room temperature under solvent free conditions. The title compounds are characterized by IR, (1)H-, (13)C-, (31)P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.