ABSTRACT
The structure and hormonal activity of the thyroid gland and its capacity to bind (3)H-melatonin were studied in young adult Chinchilla rabbits with pineal gland hypofunction induced by 2-month exposure to constant illumination. After 2 months of constant exposure to light, the experimental animals exhibited signs of the so-called "latent hypothyroidism" and more intense binding of (3)H-melatonin by the thyroid gland. This fact indicated intactness of its receptor system underlying the possibility of restoring activity of the thyroid gland under conditions of melatonin replacement therapy in hypothyroidism induced by chronic melatonin insufficiency.
Subject(s)
Melatonin/metabolism , Pineal Gland/physiopathology , Thyroid Gland/metabolism , Animals , Hypothyroidism/physiopathology , Light/adverse effects , Male , Melatonin/therapeutic use , Pineal Gland/metabolism , Rabbits , Thyroid Hormones/bloodSubject(s)
Adrenal Cortex/radiation effects , Environmental Exposure , Power Plants , Radioactive Hazard Release , Thyroid Gland/radiation effects , Adaptation, Physiological , Adrenal Cortex/metabolism , Female , Humans , Hypothyroidism/etiology , Hypothyroidism/physiopathology , Infant , Infant, Newborn , Iodine Radioisotopes , Pituitary Gland/metabolism , Pituitary Gland/radiation effects , Pregnancy , Prenatal Exposure Delayed Effects , Republic of Belarus , Thyroid Gland/metabolism , UkraineSubject(s)
Accidents , Infant, Newborn , Nuclear Reactors , Pregnancy , Radiation Injuries , Adult , Female , Health Status , Humans , Labor, Obstetric , Republic of Belarus , UkraineABSTRACT
The authors offer new laboratory methods for comprehensive assessment of the health status of the newborns. Introduction of these methods in practical activity of clinical diagnostic laboratories of therapeutic and prophylactic institutions will promote early diagnosis of some diseases in the newborns and help comprehensively assess the neonates' adaptation potential, this being valuable for successful management of the babies.