ABSTRACT
Ectericide is a product of cod-liver oil oxidation (lower fatty acids, organic peroxides and aldehydes). Its antibacterial activity is based on the capacity for partial disintegration and extraction of the structural lipopolysaccharide of the microbial cell without any significant effect on the quantitative content of the structural proteins and nucleotides.
Subject(s)
Anti-Infective Agents, Local/pharmacology , Proteus mirabilis/drug effects , Staphylococcus aureus/drug effects , Chemical Phenomena , Chemistry , Lipids/analysis , Lipopolysaccharides/analysis , Polysaccharides, Bacterial/analysis , Proteus mirabilis/analysis , Solubility , Staphylococcus aureus/analysis , Tissue ExtractsSubject(s)
Anti-Infective Agents, Local/pharmacology , Antitubercular Agents/pharmacology , Mycobacterium tuberculosis/drug effects , Energy Metabolism/drug effects , Enzyme Repression/drug effects , Mycobacterium bovis/drug effects , Mycobacterium tuberculosis/metabolism , Species Specificity , Tissue Extracts , Virulence/drug effectsABSTRACT
Research work has been carried out with the aim of obtaining hyperimmune antitoxic plasma against Pseudomonas aeruginosa. Hyperimmune plasma active against P. aeruginosa toxin has been obtained from donors immunized with P. aeruginosa toxoid. The preparation is highly specific and active, which is revealed by in vivo and in vitro tests. The clinical study of the preparation indicates its high efficacy in the treatment of diseases caused by different P. aeruginosa serotypes.