ABSTRACT
Influence of probiotic fermented milk product on the intestinal microbiota, hematological parameters and immune status of the experiment in vivo at Wistar rats was studied. It was shown, that entering of probiotic strains of Bifidobacterium bifidum 791, Bifidobacterium longum B-379M and Lactobacillus acidophilus NK1 u Streptococcus thermophilus in composition fermented milk products in the total quantity of 2,1 x 10(7) CFU/ sm3 in digestive tract within three weeks has a positive influence on the resident of colon microbiota. Significant increasing of population levels of Bifidobacterium, Enterobacteriaceae with normal biochemical properties, registered a strong tendency to increase the content of Lactobacteria, which led to a decreasing the number of potential pathogenic transient flora with pathogenic factors. Monitoring of body mass in experimental animals has shown that including of fermented milk product with probiotic strains in diet has a positive influence on the feed uptake. Probiotic properties of the product also have stimulated effect on the immune status of the rat: improvements in cell immunity (increasing the relative amount of T-helper cells, immuneregulatory index) and hematological parameters (increase
Subject(s)
Colon , Cultured Milk Products/microbiology , Immunity, Cellular/drug effects , Probiotics/pharmacology , Animals , Bifidobacterium/growth & development , Blood Cell Count , Body Weight/drug effects , Colon/drug effects , Colon/microbiology , Erythrocytes/cytology , Erythrocytes/drug effects , Hemoglobins/analysis , Lactobacillus acidophilus/growth & development , Leukocytes/cytology , Leukocytes/drug effects , Lymphocytes/cytology , Lymphocytes/drug effects , Lymphocytes/immunology , Male , Rats , Rats, Wistar , Streptococcus thermophilus/growth & developmentABSTRACT
A four-week experiment dealing with the intragastric administration of fullerene C60 dispersion to rats has established that this substance in a dose of 1 to 10 mg/kg body weight causes a number of changes in the parameters of animals, such as reductions in relative liver weight and isoform CYP 1A2 activity and increases in glutathione reductase activity, eosinophils, and neutrophils. It is concluded that fullerene can affect the animals when orally given in the doses studied.
Subject(s)
Fullerenes/toxicity , Gastrointestinal Tract/drug effects , Hygiene , Nanoparticles , Toxicology , Administration, Oral , Animals , Cytochrome P-450 Enzyme System/metabolism , Erythrocyte Count , Erythrocytes/cytology , Erythrocytes/drug effects , Erythrocytes/metabolism , Fullerenes/chemistry , Fullerenes/pharmacokinetics , Gastrointestinal Tract/metabolism , Glucuronosyltransferase/metabolism , Glutathione Transferase/metabolism , Intestinal Absorption , Leukocyte Count , Lipid Peroxidation/drug effects , Lipid Peroxides/blood , Male , Rats , Rats, Wistar , Solubility , Toxicity Tests, SubchronicABSTRACT
Influence of probiotic fermented milk products on the intestinal flora, hematological parameters and immune status of the experiment in vivo at rats is studied. Entering in digestive tract of probiotic strains of Lactobacillus acidophilus NK-1 and Bifidobacterium bifidum 791 at the level of hundreds of millions CFU in a day (from 1,7 x 10(8) to 9 x 10(8) CFU) in composition fermented milk products renders on the whole positive, but not significant statistically influence on the indexes of colon microflora and immune status of rats, and it must be extended for the achievement of reliable effect.
Subject(s)
Cultured Milk Products , Hematopoiesis , Immunity, Cellular , Intestines , Probiotics/pharmacology , Animals , Bifidobacterium/immunology , Intestines/immunology , Intestines/microbiology , Lactobacillus acidophilus/immunology , Male , Rats , Rats, WistarABSTRACT
Study of antagonistic activity of 33 strains of Lactobacillus isolated from the industrial preparation of fermented milk products, starter cultures and biologically active additives and products of natural fermentation. Antagonistic activity was studied by agar diffusion method with holes. Strains isolated from products of natural fermentation showed high degree of antagonistic action together with industrial strains.
Subject(s)
Cultured Milk Products/microbiology , Foodborne Diseases/microbiology , Lactobacillus/growth & development , Lactobacillus/metabolism , Species SpecificityABSTRACT
Radiative and hygienic passportization is one of the most actual pattern of socio and hygienic monitoring in Armed Forces. Radiative and hygienic passport is the main document which characterizes the safety control in military unit and uses the sources of ionizing radiation. Sanitary and epidemiologic institutions were imputed to control the formation of radiative and hygienic passports, analysis and generalization of its data, formation of conclusions about the condition of radiation security in the military units. According to radiative and hygienic passportization, which took place in 2009, the radiation security in the Armed Forces and organizations is satisfactory, but there are some problems of providing of radiation security of personnel under the professional and medical radiation. The salvation of its problems requires the effective work of official functionary of radiac object and institutions of state sanitary and epidemiological supervision in Armed Forces of Russian Federation.
