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Vopr Virusol ; 49(5): 28-32, 2004.
Article in Russian | MEDLINE | ID: mdl-15529861

ABSTRACT

The morbidity structure was analyzed in children vaccinated against epidemic parotitis in 1993-2002. Eight children (4 with serous meningitis and 4 with lesions of the salivary glands) underwent virologic and immunologic examinations. The molecular typing of the SH-gene fragment of the parotitis virus showed the process in 7 cases to be provoked by the vaccination strain. Presumedly, progressing vaccine-associated meningitis inhibits antibody formation. The total incidence of vaccine-associated meningitis was shown, according to Saint Petersburg data, to be not high, which testifies to a low reactogenicity of the Russian vaccine strain.


Subject(s)
Meningitis/etiology , Mumps Vaccine/adverse effects , Mumps/etiology , Mumps/prevention & control , Rubulavirus , Vaccination/adverse effects , Adolescent , Antibodies, Viral/blood , Antigens, Viral/analysis , Child , Child, Preschool , Humans , Incidence , Infant , Meningitis/blood , Mumps/epidemiology , Phylogeny , Retrospective Studies , Rubulavirus/genetics , Rubulavirus/immunology , Rubulavirus/isolation & purification , Russia/epidemiology , Salivary Glands/pathology , Salivary Glands/virology , Urban Population , Viral Proteins/genetics
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