ABSTRACT
The ultralow-intensity electromagnetic fields (EMF, frequency of 4200, modulated by a quasistochastic signal in the range of 20-20,000 Hz, power density of 15 microW/cm2, specific body absorption rate up to 4.5 mJ/kg) potentiated the hypnogenic effect of hexenal. The exposure to the EMF shortened the time of falling asleep induced by this drug and increased sleep duration in rats. The exposure to the EMF also potentiated haloperidol catalepsy: it decreased the drug threshold dose and increased the catalepsy duration. The EMF influence on the haloperidol effects was of a prolonged character: it was manifest in a selected suppression of the emotional excitation in the open-field test within 24 hours after the exposure.
Subject(s)
Electromagnetic Fields , Psychotropic Drugs/pharmacology , Animals , Behavior, Animal/drug effects , Behavior, Animal/radiation effects , Catalepsy/chemically induced , Haloperidol/pharmacology , Hexobarbital/pharmacology , Male , Rats , Rats, Wistar , Sleep/drug effects , Sleep/radiation effectsABSTRACT
The effects of the ultralow-intensity electromagnetic fields (EMF, frequency of 4200 and 970 MHz, modulated by a quasistochastic signal in the range of 20-20,000 Hz, power density 15 microW/cm2, specific body absorption rate up to 4.5 mJ/kg) on the reactions of the central nervous system (CNS) of rats with different types of behavior were studied. Some neurochemical and behavioral mechanisms of rats' reactions were investigated. It was shown that the EMF produce pronounced changes in the state and activity of monoaminergic brain systems. These changes, on the whole, correspond to the alterations at the integrative level (predominantly, of the inhibitory character).
Subject(s)
Body Constitution/physiology , Electromagnetic Fields , Higher Nervous Activity/radiation effects , Animals , Biogenic Monoamines/analysis , Biogenic Monoamines/radiation effects , Brain Chemistry/radiation effects , Chromatography, High Pressure Liquid , Conditioning, Classical/physiology , Conditioning, Classical/radiation effects , Emotions/physiology , Emotions/radiation effects , Higher Nervous Activity/physiology , Male , Motor Cortex/chemistry , Motor Cortex/radiation effects , Rats , Rats, Wistar , Statistics, Nonparametric , Time FactorsABSTRACT
Behavioral and neurochemical reactions of small laboratory animals (mice and rats of different age) under exposure to ultralow-intensity electromagnetic fields (EMF, frequency of 4200 and 970 MHz, modulated by a quasistochastic signal in the range of 20-20,000 Hz, power density 15 microW/cm2, specific body absorption rate up to 4.5 mJ/kg) were studied. The EMF basically inhibited the locomotor and exploratory activity in the "open-field" test. The species- and age-specific features rather than radiation conditions dominated. However, decrease in the EMF frequency considerably intensified the observed effect. Change in animal behavior was accompanied by shifts in neurochemical processes, i.e., sharp activation of serotoninergic and inhibition of morepinephrinergic system.
Subject(s)
Behavior, Animal/radiation effects , Electromagnetic Fields , Motor Cortex/radiation effects , 3,4-Dihydroxyphenylacetic Acid/metabolism , Age Factors , Animals , Dopamine/metabolism , Exploratory Behavior/radiation effects , Hydroxyindoleacetic Acid/metabolism , Information Theory , Inhibition, Psychological , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Motor Cortex/metabolism , Norepinephrine/metabolism , Orientation/radiation effects , Rats , Rats, Wistar , Serotonin/metabolism , Species SpecificityABSTRACT
By means of a special technique, mobilising of a subject's selective attention upon the dynamics of the subjective sphere states, was reached. An involved biofeedback was positively reinforced by avoidance of an expected electric stimulus. The subjects revealed occurrence of an adaptive correction of their general behaviour. The EEG computer analysis manifested a specifics of structural-functional maintenance of different states evoked in the training process.
Subject(s)
Biofeedback, Psychology/physiology , Brain/physiology , Emotions/physiology , Homeostasis/physiology , Adult , Conditioning, Classical/physiology , Electroencephalography/instrumentation , Fear/physiology , Female , Galvanic Skin Response/physiology , Humans , Male , Psychophysiology , Signal Processing, Computer-Assisted/instrumentationABSTRACT
On the basis of study of mass-spectrum of blood plasma ultrafiltrate in 21 injures with severe associated trauma during first four posttraumatic days and in healthy persons one can suggest that combinations with molecular weights of 300-1050 Da are to be one of the important regulatory mechanisms of posttraumatic adaptative processes. With increasing of the injury gravity reorientation of the levels of adaptative reactions management and level enhancing of mediomolecular regulators are found to be occurred.
Subject(s)
Peptides/blood , Wounds and Injuries/blood , Wounds and Injuries/etiology , Acute Disease , Adaptation, Physiological , Gas Chromatography-Mass Spectrometry , Humans , Molecular Weight , Peptides/isolation & purification , Time Factors , UltrafiltrationABSTRACT
We suggest a mathematical model of the transmembrane ionic transport system, which can produce the damped concentration oscillations. The influence of the periodic electric field is considered under assumption, that the ionic fluxes near the membrane depend on the medium potential. The estimated resonance frequency for the K(+)-H+ antiport system in bilayer membrane is less than 1 Hz.
Subject(s)
Cell Membrane/metabolism , Electricity , Biological Transport , Carrier Proteins/metabolism , Hydrogen/metabolism , Membrane Potentials , Models, Theoretical , Potassium/metabolism , Potassium-Hydrogen AntiportersSubject(s)
Auditory Perception/physiology , Sound , Acoustic Stimulation/instrumentation , Acoustic Stimulation/methods , Animals , Equipment Design , Guinea Pigs , Mice , Pressure , Ranidae , RatsABSTRACT
Isolated pacemaker of the frog's heart served as a sensitive model to study the combined action of the low intensity electromagnetic and mechanic factors. Critical energy levels of factors, their relative efficiency in direct action on the cell were estimated. Additive effects of microwaves and ultrasound were examined. The data can be valuable for the further investigations concerning the effects of different nonionizing rays.
Subject(s)
Heart Conduction System/radiation effects , Microwaves/adverse effects , Ultrasonics/adverse effects , Animals , Electrophysiology , Heart Conduction System/physiology , In Vitro Techniques , Rana temporaria , Time FactorsABSTRACT
The pattern of changes in afferent flow from a uniform isolated receptor field (3-5 mechanoreceptor units) under the effect of unspecific external stimulus of low intensity, was studied. A diverse dynamics of the afferent flow was observed: the firing rate, relative distribution of discharges in time, the amplitude and the form of spikes, are altered. The changes occur simultaneously, as a rule, which renders the idea of afferent flow's structure rather uncertain. The growth in amplitude and the change in the form of discharges seem to be based on a synchronizing of receptor units excitation. The latter can serve as a premise for actualization of the mechanism of sensory information compression by means of involvement of parallel afferent fibres in the excitation.
Subject(s)
Mechanoreceptors/radiation effects , Microwaves , Action Potentials/physiology , Action Potentials/radiation effects , Afferent Pathways/physiology , Afferent Pathways/radiation effects , Animals , In Vitro Techniques , Mechanoreceptors/physiology , Rana temporaria , Time Factors , Urinary Bladder/innervation , Urinary Bladder/physiology , Urinary Bladder/radiation effectsSubject(s)
Electrodes , Peripheral Nerves/physiology , Animals , Electrophysiology , Rana temporaria , Urinary Bladder/innervationABSTRACT
Changes in the structure of the work done by aircraft flyers during piloting and oxygen starvation were studied. The experiments were carried out on 10 pilots who performed simulation flights while breathing hypoxic gas mixtures containing 10.5% O2 (at an altitude of 5000 m) or 9.6% O2 (at an altitude of 5600 m). These findings suggest that the earliest sign of disordered piloting during hypoxia was a delayed formation of controlling actions. At greater hypoxia noticeable changes were seen in the structure of motor activities together with distinct disturbances of coordination relations of muscles-antagonists involved in the realization of controlling movements. The sensory component suffered from the hypoxic effect to a lesser extent. Complex forms of the mental activity proved to be most resistant to hypoxia.
Subject(s)
Aerospace Medicine , Hypoxia/physiopathology , Imitative Behavior/physiology , Decision Making/physiology , Eye Movements , Humans , Models, Structural , Thinking/physiologyABSTRACT
In frongs, changes of sympathetic and parasympathetic discharges were studied in the structures of the efferent link of the cardial reflexes from carotid chemoreceptors. Both the acid and the alkaline fluids perfused through the carotid labyrinth considerably decrease the sympathetic and increase the parasympathetic discharges in the cardial branches of the vago-sympathetic trunk. Cerebral portions above the medulla oblongata exert no essential effect on the specific features of reflex changes of the efferent activity in the vago-sympathetic trunk. After separation of the medulla oblongata from the spinal cord, the sympathetic discharges do not change in response to stimulation of carotid receptors while the alteration of parasympathetic activity holds on.
