[A trial of the use of sandostatin in patients with chronic pancreatitis]. / Opyt primeneniia sandostatina u bol'nykh khronicheskim pankreatition.

Out of 15 patients with chronic pancreatitis (CP) treated with sandostatin, 8 patients demonstrated a complete and 6 partial response. One patient did not respond. Pain relief occurred in all of them. Side effects were registered in 3 patients (doughy stools 4 times a day throughout treatment). Normal blood levels of pancreatic enzymes, insulin secretion, parameters of blood inhibitory system did not change much because of sandostatin administration, whereas hypercoagulation got diminished. Rat experiments have revealed a trend to trypsin lowering in tissues of unaffected pancreas and more intensive inhibition of active trypsin by tissue inhibitors.

[The effect of protease tissue inhibitor on the activity of pancreatic proteolytic enzymes in in-vitro experiments]. / Issledovanie vliianiia tkanevogo ingibitora proteaz na aktivnost' pankreaticheskikh proteoliticheskikh fermentov v opytakh in vitro.

The authors provide the data on in vitro experimental studies into the pharmacological properties of protease inhibitor obtained from bovine pancreas. It is shown that the preparation exerts an inhibitory action on pancreatic proteolytic enzymes such as trypsin, kallikrein, and elastase, drastically reduces the total proteolytic activity in pancreatic tissue homogenates. Comparison with the protease inhibitor gordox has demonstrated the inhibitory effect of both preparations to be practically similar.

[Effect of the intake of food and of biologically active substances on the capacity of the blood serum to inhibit proteolytic activity]. / Vliianie priema pishchi i nekotorykh biologicheski aktivnykh veshchestv na sposobnost' syvorotki krovi ingibirovat' proteoliticheskuiu aktivnost'.

In experiments on rats it has been shown that the blood serum inhibiting capacity alters under the effect of biologically active substances and during digestion. Taking food, pancreozymin, serotonin and pilocarpine reduce, while vitamins (riboflavin, tocopherol and vitamin B1) elevate the level of proteolytic enzyme inhibitors in the blood serum. The capacity of vitamins to raise the blood inhibiting activity can be used in the pancreatitis management.

[Effect of serotonin on secretory and lysosomal enzyme activity in pancreatic tissue and the inhibitory properties of serum]. / Vliianie serotonina na aktivnost' sekretornykh i lizosomal'nykh fermentov v tkani podzheludochnoi zhelezy i ingibiruiushchuiu sposobnost' syvorotki krovi.

Experiments on rats have demonstrated that changes in the serotonin level in the body intensifies pancreatic function. The pancreas shows the increased contents of trypsinogen and proelastase and those of lysosomal enzymes (cathepsins and acid phosphatase). Administration of serotonin leads to the reduction of the inhibitory properties of blood serum versus proteolytic pancreatic enzymes. Administration of serotonin to animals with the preliminarily ligated pancreatic duct results in the development of pancreatitis with a pronounced fat necrosis of the pancreatic tissue.