ABSTRACT
The experiment was carried out on 120 female white Wistar rats, to study the endothelio- and osteoprotective action of the combination of rosuvastatin with L-norvaline in the model of experimental osteoporosis. It was found that, after ovariectomy in rats, endothelial dysfunction of the vessels of the microcirculatory bed of bone tissue develops, leading to the appearance of osteoporosis, but the combination of the studied drugs prevents the decrease in the level of microcirculation in the bone tissue, thereby preventing the thinning of bone trabeculae and preventing the occurrence of microfractures in them.
ABSTRACT
Experiments on laboratory animals with nitric oxide deficiency modeled by the introduction of L-NAME (NO-synthase inhibitor) revealed the endothelio- and cardioprotective effects of clarithromycin, josamycin, roxithromycin, midecamycin and azythromycin. The administration of these macrolides leads to a decrease in the resulting area of the diagram of functional indices of the state of vessels and myocardium, which is approaching the corresponding area for intact animals.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Cardiotonic Agents/therapeutic use , Endothelium, Vascular/drug effects , Hypertension/physiopathology , Macrolides/therapeutic use , Nitric Oxide/deficiency , Animals , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/pharmacology , Blood Pressure/drug effects , Cardiotonic Agents/administration & dosage , Cardiotonic Agents/pharmacology , Disease Models, Animal , Endothelium, Vascular/physiology , Heart Function Tests , Hypertension/drug therapy , Hypertension/metabolism , Macrolides/administration & dosage , Macrolides/pharmacology , Male , NG-Nitroarginine Methyl Ester/pharmacology , Rats , Rats, Wistar , Vasoconstriction/drug effectsABSTRACT
The cardioprotective and endothelioprotective effects of the macrolide antibiotics roxithromycin, azythromycin, and midecamycin have been studied on laboratory animals with models of the coronaro-occlusional myocardial infarction and endothelial dysfunction. The drugs led to a dose-dependent decrease in lethality, reduced the zone of necrosis of the left ventricle after coronary occlusion, and produced a positive effect on the functioning of endothelium.
