ABSTRACT
The paper is dedicated to the study of peculiarities of ubiquinone and ubichromenol distribution and metabolism in subcellular fractions of rats' liver under A,E-hypovitaminosis. It is shown, that dietary deprivation of vitamins A and E leads to a sharp decrease in intensity of CoQ biosynthesis in rats' liver tissue and to its intracellular redistribution. Under these circumstances the observed decrease in the inclusion of labelled tyrosine in rats' liver CoQ under A,E-hypovitaminosis may be really caused by dietary deprivation of vitamin E.
Subject(s)
Chromans/metabolism , Liver/metabolism , Ubiquinone/metabolism , Vitamin A Deficiency/metabolism , Vitamin E Deficiency/metabolism , Animals , Rats , Tocopherols/administration & dosage , Tritium , Tyrosine/chemistry , Ubiquinone/biosynthesis , Vitamin A/administration & dosage , Vitamin A Deficiency/complications , Vitamin E Deficiency/complicationsABSTRACT
The levels of vitamins in the blood of persons who suffered from the catastrophe at Chernobyl NPP subject to medically treatment at Kiev clinics at different time periods have been studied. Polyhypovitaminosis has been detected in all the patients groups examined, especially in persons with the diagnosis of acute radiation sickness. The hypovitaminosis status in the organism is regulated by means of an adequate vitamin therapy. The scientifically substantiated vitamin therapy and vitamin prophylaxis are proposed to be performed for the population of Ukraine affected by the consequences of the Chernobyl catastrophe.
Subject(s)
Environmental Health , Power Plants , Radioactive Hazard Release , Thiamine/blood , Vitamin A/blood , Vitamin E/blood , Humans , Retrospective Studies , UkraineABSTRACT
Ubiquinone and ubichromenol content was studied at different levels of organism supply with vitamin E. The content of these substances in the albino rat liver with vitamin E-deficiency is shown to decrease by 16 and 23%, respectively. The intravenous administration of alpha-tocopherol to the vitamin E-deficiency rats causes a gradual 45% increase in the ubiquinone content 4h after which remains at the same level for 8 h; the ubichromenol content 2 h latter is 1.7 times as high and then it lowers gradually up to the level in the avitaminous animals.
