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1.
Pharmacogenomics J ; 14(1): 14-9, 2014 Feb.
Article in English | MEDLINE | ID: mdl-23296156

ABSTRACT

Antibody-dependent cellular cytotoxicity (ADCC), which is activated by effector cells via immunoglobulin G (IgG) fragment C receptors (FcRs), was proposed as a mechanism of cetuximab efficacy. Peripheral blood mononuclear cells (PBMCs) from 23 healthy donors and 13 patients with metastatic colorectal cancer (mCRC) treated with cetuximab were tested for FcγR polymorphisms and cetuximab-mediated ADCC. ADCC was measured by chromium-51 release on a epidermal growth factor receptor (EGFR)-positive human colon cancer cell line. Overall, 86 mCRC patients were genotyped for study purposes. PBMCs harbouring the FcγRIIIa 158 V/V genotype had a significantly higher cetuximab-mediated ADCC. No correlation was found between FcγR polymorphisms and response rate or time to progression after cetuximab-based therapy. Despite the in vitro analysis showing that the FcγRIIIa 158 V/V genotype is associated with higher ADCC, clinical data do not support a predictive role of FcγRIIIa polymorphisms in mCRC treated with cetuximab.


Subject(s)
Antibodies, Monoclonal, Humanized/therapeutic use , Antibody-Dependent Cell Cytotoxicity/genetics , Antineoplastic Agents/therapeutic use , Colorectal Neoplasms/drug therapy , Polymorphism, Genetic , Receptors, IgG/genetics , Adult , Aged , Aged, 80 and over , Antibodies, Monoclonal, Humanized/administration & dosage , Antineoplastic Agents/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cetuximab , Colorectal Neoplasms/genetics , Colorectal Neoplasms/metabolism , Colorectal Neoplasms/pathology , Disease-Free Survival , Female , Genotype , Humans , Leukocytes, Mononuclear , Male , Middle Aged , Predictive Value of Tests , Treatment Outcome
2.
Acta Radiol ; 47(2): 167-71, 2006 Mar.
Article in English | MEDLINE | ID: mdl-16604963

ABSTRACT

Although primary cardiac lymphoma is an extremely rare disease and is associated with high mortality, it is treatable when diagnosed appropriately. We describe the transthoracic echocardiography, 16-row multidetector computed tomography (16-MDCT) and magnetic resonance findings of primary cardiac lymphoma in an immunocompromised patient and review of the literature.


Subject(s)
Burkitt Lymphoma/diagnosis , Heart Neoplasms/diagnosis , Aged , Diagnosis, Differential , Echocardiography , Humans , Immunocompromised Host , Magnetic Resonance Imaging , Male , Tomography, X-Ray Computed
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