ABSTRACT
In spite of the availability of many antituberculosis drugs all over the world the morbidity of tuberculosis does not lower. Often the tuberculosis therapy schemes are adapted to every particular patient which is mainly due to the therapy unfavourable effects requiring discontinuation of the drugs used. Polymorphism of the detoxication genes, as predictors of the response to the drug therapy, was shown to be of certain significance. The experimental data would allow to substantiate personalized management of tuberculosis patients and to increase its efficacy and safety.
Subject(s)
Antitubercular Agents/therapeutic use , Arylamine N-Acetyltransferase/genetics , Cytochrome P-450 CYP2C9/genetics , Cytochrome P-450 CYP2E1/genetics , Precision Medicine/methods , Tuberculosis, Pulmonary/drug therapy , Adult , Algorithms , Antitubercular Agents/adverse effects , Antitubercular Agents/pharmacokinetics , Female , Humans , Male , Medical Records , Middle Aged , Polymorphism, Genetic , Tuberculosis, Pulmonary/genetics , Young AdultABSTRACT
The urine levels of cortisol and 6-beta-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-beta-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the age sex. At the age of 4 to 9 years the value of the ratio was 9.21 +/- 0.67 which in fact was statistically higher than that in the children at the age of 0 to 3 years (p<0.001). In the female children at the age of 0 to 3 years the value of the isoenzyme CYP3A4 activity was actually lower (p<0,05) vs. the female children of the higher ages and the male children at the age of 0 to 3 years. The results are useful for further researches on improvement of drugs dosing and prevention of adverse reactions.
