1.
Br J Haematol
; 159(2): 211-5, 2012 Oct.
Article
in English
| MEDLINE
| ID: mdl-22924607
ABSTRACT
We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (4000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82·5% and 52·5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD. Larger prospective studies with longer duration are needed to confirm these effects.
Subject(s)
Anemia, Sickle Cell/drug therapy , Pain/drug therapy , Vitamin D/administration & dosage , Adolescent , Adult , Anemia, Sickle Cell/blood , Anemia, Sickle Cell/complications , Calcifediol/pharmacokinetics , Child , Double-Blind Method , Female , Humans , Male , Pain/blood , Pain/etiology , Prospective Studies , Vitamin D/pharmacokinetics
2.
Br J Haematol
; 153(4): 538-40, 2011 May.
Article
in English
| MEDLINE
| ID: mdl-21275953