[Leukocyte function as one of the indices of resistance to influenza in children]. / Funktsional'noe sostoianie leikotsitov kak odin iz pokazatelei rezistentnosyti detei k grippu.

Preliminary results of comparative characterization of the functional activity of leukocytes by cytochemical, virologic, immunologic, and clinical methods of examinations in institutionalized young infants are summarized. The observations covered 100 infants varying in ages from 1 to 3 years with frequent and rare incidence of respiratory diseases. The diagnosis of influenza had been confirmed by serological methods: CFT and ELISA. Infants with positive serodiagnosis were selected for further studies. The functional status of leukocytes was determined by the interferon leukocyte test (ILT), alkaline phosphatase and myeloperoxidase activities. The results presented in the Tables have shown the infants frequently suffering from ARVD to have low values of ILT and higher values of alkaline phosphatase activity but low myeloperoxidase activity. More resistant infants with rare incidence of ARVD had high ILT, high myeloperoxidase activity and low alkaline activity. It is suggested that alkaline activity of leukocytes alone may be of informative value.

[Prevention of the anti-interferon effect of exogenous leukocyte interferon in children]. / Profilakticheskii antigrippoznyi éffekt ékzogennogo leikotsitarnogo interferona u detei.

The preventive effect of exogenous leukocyte interferon used twice weekly at a 3-day interval in the period of an influenza epidemic as well as the effect of this preparation on the capacity of leukocytes to produce endogenous interferon were studied in young infants brought to nurseries. The observations covered 146 infants varying in ages from 11 months to 31/2 years, of them 104 infants were given interferon intranasally from an automizer (conditional experimental group) and 42 received no interferon (conditional) control group). During the period of interferon prophylaxis (5 weeks) a significant. 7-fold, reduction in the morbidity rate was observed in the group given interferon as compared to the control group. Observations in the time course showed a reduced incidence in the experimental group for a year. During the use of interferon in infants there was an increase in the capacity to produce endogenous interferon as manifested by a significant rise in titres by the end of interferon prophylaxis.