ABSTRACT
AIM: To evaluate bekotid and bekodisk effects on bronchial reactivity and sensitivity. MATERIALS AND METHODS: Bronchial reactivity and sensitivity were studied in a comparative study of two corticosteroids for inhalation--bekotid and bekodisk--in 37 patients with bronchial asthma. Unlike bekotid, bekodisk does not contain freon which irritates mucosa of the upper respiratory tracts and bronchi. The examination included clinical and allergological tests, provocative inhalation tests, peak flowmetry, assessment of bronchial resistance and external respiration function. RESULTS: Bekodisk treatment reduced the number of asphyxia episodes, sensitivity to carbacholine, the need in inhalation sympathomimetics, improved external respiration function. CONCLUSION: Determination of reactivity and sensitivity of the bronchi is essential for comparison of drugs against bronchial asthma. Bekodisk significantly lowers reactivity to nonspecific mediatory substances, is simple and available in application, is more tolerable than bekotid.
Subject(s)
Airway Resistance/drug effects , Anti-Asthmatic Agents/therapeutic use , Asthma/physiopathology , Beclomethasone/therapeutic use , Bronchial Hyperreactivity/physiopathology , Glucocorticoids/therapeutic use , Hydroxycorticosteroids , Administration, Inhalation , Anti-Asthmatic Agents/administration & dosage , Asthma/diagnosis , Asthma/drug therapy , Beclomethasone/administration & dosage , Bronchial Provocation Tests , Bronchoscopy , Carbachol/administration & dosage , Cholinergic Agonists/administration & dosage , Evaluation Studies as Topic , Female , Glucocorticoids/administration & dosage , Humans , Male , Treatment OutcomeSubject(s)
Asthma/etiology , Larva Migrans, Visceral/complications , Toxocara canis , Animals , Asthma/immunology , Eosinophilia/etiology , Eosinophilia/immunology , Eosinophils/immunology , Humans , Hypersensitivity, Delayed/etiology , Hypersensitivity, Delayed/immunology , Hypersensitivity, Immediate/etiology , Hypersensitivity, Immediate/immunology , Immunoglobulin E/immunology , Larva Migrans, Visceral/immunology , T-Lymphocytes/immunology , Toxocara canis/immunologyABSTRACT
The authors show that the response of the respiratory system on additional resistance induced by RR depends on personal anxiety of the patient. Respiratory training with RR improves the condition of the respiratory system and psychological status of asthmatics. The training should be adjusted to psychological peculiarities of each patient and conducted according to individual program. Previous test for reaction of the respiratory system to additional exogenic resistance is needed.
Subject(s)
Anxiety/diagnosis , Anxiety/psychology , Asthma/psychology , Asthma/therapy , Respiration, Artificial , Adult , Female , Humans , Male , Middle Aged , Severity of Illness IndexABSTRACT
The response to lomuzol was registered in 37 out of 39 patients with allergic rhinitis given lomuzol. In 16 patients the response was complete, in 14 partial, in 7 satisfactory. In 6 patients of placebo no effect was recorded. The drug proved uneffective in hypertrophy of the turbinate bones.
Subject(s)
Anti-Asthmatic Agents/therapeutic use , Cromolyn Sodium/therapeutic use , Rhinitis, Allergic, Perennial/drug therapy , Adolescent , Adult , Allergens , Female , Humans , Male , Middle Aged , Placebos , Rhinitis, Allergic, Perennial/diagnosisABSTRACT
Bronchial asthma (BA) patients with hyperventilation (HV) were examined by means of evoked cutaneous sympathetic potential (ECSP) and short-latency evoked stem potentials to acoustic stimulation (SLESP to AS). Measurements of these parameters allowed quantitation and differentiation of hyperventilation disorders in BA patients. The latter were divided into 4 groups: BA patients with HV syndrome (HVS), BA patients with functional HV (FHV), BA patients with spontaneous HV (SHV) and BA patients without HV. BA patients with HVS exhibited a significant increase of latent ECSP period and latent periods III and V SLESP to AS peaks. This evidences for vegetative neuropathy and dysfunction of the pons and mesencephalic brain compartments. In BA patients with FHV there was a longer latent period II of SLESP to AS peak indicating dysfunction of caudal brain stem. BA patients with SHV and without HV had no significant shifts.
Subject(s)
Asthma/physiopathology , Hyperventilation/physiopathology , Adolescent , Adult , Asthma/complications , Evoked Potentials/physiology , Evoked Potentials, Auditory, Brain Stem/physiology , Female , Humans , Hyperventilation/etiology , Male , Middle Aged , Neurologic Examination , Reaction Time/physiology , Respiratory Function Tests , Skin/innervation , Skin Physiological Phenomena , Sympathetic Nervous System/physiopathologySubject(s)
Aspergillosis/etiology , Aspergillus niger , Asthma/complications , Candidiasis/etiology , Lung Diseases, Fungal/etiology , Adult , Aspergillosis/diagnosis , Aspergillosis/therapy , Asthma/diagnosis , Asthma/therapy , Candidiasis/diagnosis , Candidiasis/therapy , Chronic Disease , Combined Modality Therapy , Diagnosis, Differential , Humans , Lung Diseases, Fungal/diagnosis , Lung Diseases, Fungal/therapy , Male , RecurrenceSubject(s)
Biomarkers , CD4-CD8 Ratio , CD4-Positive T-Lymphocytes/immunology , Lymphocyte Activation/immunology , T-Lymphocytes, Regulatory/immunology , Adolescent , Adult , CD4-Positive T-Lymphocytes/drug effects , Female , HLA-DR Antigens/immunology , Humans , Male , Middle Aged , Phytohemagglutinins/pharmacology , T-Lymphocytes, Regulatory/drug effectsSubject(s)
Asthma/physiopathology , Hyperventilation/psychology , Skin/innervation , Sympathetic Nervous System/physiopathology , Adolescent , Adult , Asthma/complications , Evoked Potentials/physiology , Female , Humans , Hyperventilation/complications , Hyperventilation/physiopathology , Male , Middle Aged , SyndromeABSTRACT
Skin reaction on phytohemagglutinin in healthy people and in patients with allergic bronchial asthma before and after specific hyposensitization has been studied. The attempt to determine interrelations between the skin sensitivity to phytohemagglutinin and some immunity indexes and to explain several links of lectins' action mechanisms during allergic processes have been made.
Subject(s)
Asthma/immunology , Lectins/physiology , Phytohemagglutinins , Adult , Asthma/microbiology , Asthma/therapy , B-Lymphocytes , Desensitization, Immunologic , Female , Humans , Immunoglobulins/blood , Leukocyte Count , Male , Middle Aged , Neisseria/physiology , Reference Values , Skin Tests , Staphylococcus aureus/physiology , T-LymphocytesABSTRACT
The study revealed the relation of bronchial asthma (bacterial variant) clinical pattern to plasma levels of PGF2 alpha, 6-keto-PGF1 alpha and TxB2. In remission of the disease the above indices are lower. Severe asthma remission is characterized by higher levels of 6-keto-PGF1 alpha and TxB2 than moderate asthma one, demonstrates a tendency to growing PGF2 alpha levels. A rise in PGF2 alpha and TxB2 in manifest asthma points to their participation in bronchospasm formation suggesting an active role of these bronchoconstrictors in asthma pathogenesis. Higher levels of 6-keto-PGF1 alpha are of a compensary nature in the pathogenesis of PGF2 alpha and TxB2 bronchoconstrictory action, and of damaging nature contributing to the formation of bronchial mucosa edema and bronchial gland hypersecretion.
Subject(s)
6-Ketoprostaglandin F1 alpha/blood , Asthma/blood , Dinoprost/blood , Thromboxane A2/blood , Adolescent , Adult , Asthma/etiology , Asthma/therapy , Female , Humans , Male , Middle Aged , Remission Induction , Severity of Illness IndexSubject(s)
Allergens/adverse effects , Native Hawaiian or Other Pacific Islander , Railroads , Adolescent , Adult , Child , Humans , Hypersensitivity/epidemiology , Hypersensitivity/etiology , Middle Aged , Native Hawaiian or Other Pacific Islander/statistics & numerical data , Prevalence , Racial Groups , Siberia/epidemiologySubject(s)
Anaphylaxis/diagnosis , Arthropod Venoms/adverse effects , Drug Hypersensitivity/diagnosis , Railroads , Respiratory Hypersensitivity/diagnosis , Adolescent , Adult , Age Factors , Aged , Anaphylaxis/epidemiology , Anaphylaxis/etiology , Child , Drug Hypersensitivity/epidemiology , Drug Hypersensitivity/etiology , Female , Humans , Male , Middle Aged , Respiratory Hypersensitivity/epidemiology , Respiratory Hypersensitivity/etiology , Sex Factors , Siberia/epidemiology , Surveys and QuestionnairesABSTRACT
There is a relationship between severity of bacterial bronchial asthma clinical symptoms and plasma 6-keto-PGF1 alpha, TxB2: in moderate disease against grave one as well as in clinical versus subclinical forms (remission) relevant indices are reduced. On the one hand elevated content of blood 6-keto-PGF1 alpha seems compensatory rising in response to TxB2 bronchoconstriction. On the other hand, it impairs microcirculation and enhances mediators of inflammation, promotes exudation and edema of bronchoalveolar mucosa, thus contributing to obstruction.
Subject(s)
6-Ketoprostaglandin F1 alpha/blood , Asthma/blood , Thromboxane B2/blood , Adolescent , Adult , Asthma/physiopathology , Bronchi/physiopathology , Constriction, Pathologic , Female , Humans , Male , Microcirculation , Middle AgedABSTRACT
Quantitation of glucocorticoid receptors (GCR) and the study of their affinity for glucocorticosteroids (GCS) were made in peripheral blood lymphocytes of bronchial asthma (BA) patients in consideration of GCR treatment and serum levels of endogenous cortisol. It is stated that GCR of healthy controls and GCS-untreated patients outnumbered those of cortisol-dependent BA patients on hormone therapy. Following discontinuation of glucocorticoid drugs GCR count in cortisol-dependent BA tends to rise. Endogenous cortisol has no effect on GCR level estimated by 3H-triamcinolone acetonide.
Subject(s)
Asthma/blood , Hydrocortisone/blood , Lymphocytes/chemistry , Receptors, Glucocorticoid/blood , Adolescent , Adult , Asthma/drug therapy , Female , Glucocorticoids/therapeutic use , Humans , Male , Middle AgedABSTRACT
Pharmacokinetics of theopek--a new original slow release formulation of theophylline--as compared with theotard and theodur was studied in patients with bronchial asthma. The pharmacokinetic parameters of this product were shown to be comparable. A significant correlation between blood theophylline concentration and the bronchodilating and diuretic effects in patients with bronchial asthma was revealed.
