[Effect of hemosorption on microcirculation, humoral autoimmunity and lipid peroxidation in patients with stable angina pectoris]. / Vliianie gemosorbtsii na sostoianie mikrotsirkuliatsii, gumoral'nogo autoimmuniteta i perekisnoe okislenie lipidov u bol'nykh so stabil'noi stenokardiei.

Microhemo- and lymphocirculation, capillary permeability, humoral autoimmunity and lipid peroxidation were determined in 46 patients with Functional Classes III-IV stable angina concurrent with multiple atherosclerotic coronary lesions 24 hours following the second hemosorption session. The clinical efficiency of hemosorption was observed in 47.8% of patients with stenotic coronary atherosclerosis refractory to antianginal therapy. In this group of patients, hemosorption led to accelerated microcirculation, increased microcirculatory reserve potentials and decreased microvascular resistance at rest and in reactive postischemic hyperemia. In patients with abnormal humoral autoimmunity and lipid peroxidation, hemosorption resulted in their hormalization.

[Dyslipidemia and an elevated lipid level in the cells in experimental herpetic infection and their correction with antiviral chemotherapeutic agents]. / Dislipidemiia, povyshennoe soderzhanie v kletkakh lipidov pri éksperimental'noi gerpeticheskoi infektsii i ikh korrektsiia antivirusnymi khimiopreparatami.

The influence of herpes simplex virus on lipid exchange and accumulation by blood vessels cells was studied. In acute herpes infection in rabbits, typical dyslipidemia characterised by a rise in the content of total cholesterol, low and very low density lipoprotein cholesterol and triglycerides in the absence of manifest changes in concentration of high density lipoprotein was detected. HSV infection of smooth muscle cell culture of human embryo aorta was accompanied by increased accumulation of free lipids in the cells. The use of antiherpetic preparations during the infection led to correction of the lipid spectrum of the infected animals and was accompanied by normalization of intracellular lipid contents. A possible pathogenetic role of HSV in atherogenesis which may be connected with at least two processes: the development of lipidemic disturbances and formation of pathologic lipid depot in the arterial wall, is discussed.

[Effect of xanthinol niacinate on the autoimmunity and capillary permeability in patients with stable stenocardia]. / Vliianie ksantinol-nikotinata na sostoianie autoimmuniteta i pronitsaemost' kapilliarov u bol'nykh so stabil'noi stenokardiei.

A three-month antianginal therapy with long-acting nitrates and xanthinol nicotinate given in various daily doses have shown that there is a positive clinical effect, a reduction in the level of immune complexes and IgG in most patients, which is followed by a decrease in capillary permeability and dienic conjugate levels both in erythrocytes and plasma.

[Bioenergetic processes in erythrocytes from patients with stable stenocardia]. / Bioénergeticheskie protsessy v éritrotsitakh bol'nykh stabil'noi stenokardiei.

Distinct impairments in energy metabolism were detected in erythrocytes of patients with persistent stenocardia. These impairments occurred both in the rate of high-energy substances synthesis and in their utilization. Possible mechanisms for regulation of bioenergetic processes in red blood cells under conditions of ischemic heart disease are discussed.

[A method of determining the permeability of erythrocyte membranes for monovalent ions]. / Metod opredeleniia pronitsaemosti membran éritrotsitov dlia monovalentnykh ionov.

A modified method for the determination of red cell membrane permeability for sodium and potassium monovalent ions is described. The described modification essentially cuts down the time of investigation and accelerates potassium ion transport. Instead of ouabain, an imported reagent, strophanthin K glycoside manufactured in the USSR is used in the test.

[Hypoinsulinemia and bioenergetic processes in the rat cerebral cortex]. / Gipoinsulinemiia i bioénergeticheskie protsessy v kore bol'shikh polusharii mozga krys.

Increase in activity of lactate dehydrogenase, of its isoenzymes LDH1, LDH2 and LDH3 as well as in content of lactic acid with simultaneous decrease in the pyruvic acid content were found in brain hemispheres of rats with alloxan diabetes. A decrease in the rate of energy reactions in rat brain hemispheres, caused by impairment of glucose oxidation in the Krebs cycle, proved to be the specific property of metabolic alterations in these cells under conditions of hypoinsulinemia.

[Energy metabolism in the kidney cortex of rats with alloxan diabetes]. / Energeticheskii obmen v korkovom sloe pochek krys s alloksanovym diabetom.

Activity of lactate dehydrogenase was decreased in kidney cortex of rats with alloxane diabetes. The lactate dehydrogenase activity, catalyzing the lactate transformation into pyruvate, was increased. Activation of the pentosephosphate pathway enzymes was the characteristic property of metabolism impairments in kidney tissue under conditions of alloxane diabetes.

[Changes in liver enzyme activity in alloxan diabetes rats]. / Izmenenie aktivnosti fermentov v pecheni krys pri alloksanovom diabete.

Activities of pyruvate kinase, lactate and malate dehydrogenases as well as concentration of oxaloacetate, lactic and pyruvic acids and of glycerol-I-phosphate were altered in liver tissues of rats with alloxane diabetes. Alteration in activity of LDH and MDH isoenzymes appears to be responsible for regulation of the content of pyrimidine nucleotides oxidized and reduced forms, which limit the glucose oxidation.