[Clinical aspects and significance of measuring concentrations of neuroleptics and antidepressants in the blood]. / Klinicheskie aspekty i znachenie izmereniia kontsentratsii neiroleptikov i antidepressantov v krovi.

The paper presents a survey about assays of plasma levels of drugs in psychiatry. Special attention is paid to the correlation between plasma levels of antidepressants and neuroleptics and therapeutic efficacy.

[Clinical efficacy of leponex according to the findings of an international study]. / Klinicheskaia éffektivnost' leponeksa po dannym mezhdunarodnogo issledovaniia.

Leponex was used to treat 120 schizophrenic patients with doses varying from 50 to 550 mg and the course of therapy lasting for two months. Considerable specificities were revealed in the spectrum of the drug psychotropic activity and the nature of its side effects. Leponex was especially effective in cases of delirious, hallucinational and catatonic symptomatology. This drug was proved to be a method of choice in progressive protracted schizophrenic psychoses accompanied by the above disorders. The regimen of gradual and slow accretion of daily doses throughout the treatment with leponex utilized in this study is assessed as optimal for preventing the development of toxic side effects associated with the use of this drug.