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Izv Akad Nauk SSSR Biol ; (4): 575-81, 1992.
Article in Russian | MEDLINE | ID: mdl-1280659

ABSTRACT

A bioenergetic conception of insulin-independent diabetes mellitus (IIDM) is put forward. Molecular mechanisms of carbohydrate and fat metabolism are discussed which result in a vicious regulatory cycle to provoke a transition to stable pathology. Previously unknown role of human saliva in oral cavity in this regulatory cycle is revealed. New diagnostic tests are developed on the basis of the conception on IIDM pathogenesis. The results of clinical trials are presented which have been obtained during population screening.


Subject(s)
Carbohydrate Metabolism , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/etiology , Diabetes Mellitus, Type 2/metabolism , Diagnosis, Differential , Energy Metabolism , Fatty Acids/metabolism , Glucose/analysis , Humans , Saliva/chemistry , Saliva/metabolism , Staining and Labeling
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