Venous Irritation Incidence Associated with Vinorelbine Tartrate Injection Time / 대한암학회지

PURPOSE: This study was to determine the incidence and severity of venous irriation in patients receiving vinorelbine tartrate (Navelbine ) in combination chemotherapy. MATERIAL AND METHODS: Twenty four patients histologically confirmed non-small cell lung cancer were enrolled in this study who receiving vinorelbine in combination chemotherapy through a peripheral vein from Oct. 1997 to Mar. 1999 with retrospective study design method. One group was 6~10 minutes infusion rate, the other was 10~20 minutes infusion rate with the same free-flow intravenous infusion. RESULTS: A total of 126 infusions were observed in this study. Sixty-two infusions were admi nistered at the 6~10 minutes, and 64 infusions were administered at the 10~20 minutes. The incidence of any venous irritation was 3.2% (2/62) in the group that received the infusion in 6~10 minutes and 10.9% (7/64) in 10~20 minutes (p=0.164), so we could not acquire any statistical significance. However the incidence of severe venous irritation (grade 3, 4) was 0% (0/62) in 6~10 minutes infusion group and 9.4% (6/64) in 10~20 minutes infusion group. There was a significant difference between two groups (p=0.028) CONCLUSION: Our results suggest that venous irritation associated with vinorelbine tartrate infusion can be reduced by shorter duration of administration and vinorelbine tartrate might be recom mended to administer at 6~10 minutes infusion in clinical practice.

A case of small cell lung cancer developed in patients with dermatomyositis during therapy / 대한내과학회지

Dermatomyostis is an idiopathic inflammatory myopathy characterized by progressive symmetric proximal muscle weakness and typical cutaneous lesions. The association of adult dermatomyositis and malignancy in particular has generated much attention recently. A 66 year-old male biopsy proven dermatomyositis had bloody hemoptysis 1 week ago and skin manifestation aggravated during steroid therapy in outpatients rheumatology clinic. During routine evaluation mediastinal mass was found, and following bronchoscopic biopsy confirmed small cell lung carcinoma. In Korea a few cases were reported about stomach cancer, breast cancer and acute lymphoblastic leukemia but small cell lung cancer was not reported yet. So we reported a case of small cell lung cancer developed in patients with dermatomyosits during therapy with brief review of literatures.