ABSTRACT
BACKGROUND: Candida auris, a multidrug-resistant yeast, can spread rapidly in ventilator-capable skilled-nursing facilities (vSNFs) and long-term acute care hospitals (LTACHs). In 2018, a laboratory serving LTACHs in southern California began identifying species of Candida that were detected in urine specimens to enhance surveillance of C auris, and C auris was identified in February 2019 in a patient in an Orange County (OC), California, LTACH. Further investigation identified C auris at 3 associated facilities. OBJECTIVE: To assess the prevalence of C auris and infection prevention and control (IPC) practices in LTACHs and vSNFs in OC. DESIGN: Point prevalence surveys (PPSs), postdischarge testing for C auris detection, and assessments of IPC were done from March to October 2019. SETTING: All LTACHs (n = 3) and vSNFs (n = 14) serving adult patients in OC. PARTICIPANTS: Current or recent patients in LTACHs and vSNFs in OC. INTERVENTION: In facilities where C auris was detected, PPSs were repeated every 2 weeks. Ongoing IPC support was provided. MEASUREMENTS: Antifungal susceptibility testing and whole-genome sequencing to assess isolate relatedness. RESULTS: Initial PPSs at 17 facilities identified 44 additional patients with C auris in 3 (100%) LTACHs and 6 (43%) vSNFs, with the first bloodstream infection reported in May 2019. By October 2019, a total of 182 patients with C auris were identified by serial PPSs and discharge testing. Of 81 isolates that were sequenced, all were clade III and highly related. Assessments of IPC identified gaps in hand hygiene, transmission-based precautions, and environmental cleaning. The outbreak was contained to 2 facilities by October 2019. LIMITATION: Acute care hospitals were not assessed, and IPC improvements over time could not be rigorously evaluated. CONCLUSION: Enhanced laboratory surveillance and prompt investigation with IPC support enabled swift identification and containment of C auris. PRIMARY FUNDING SOURCE: Centers for Disease Control and Prevention.
Subject(s)
Candidiasis/diagnosis , Candidiasis/prevention & control , Subacute Care , Adult , Aged , Aged, 80 and over , California/epidemiology , Candida auris/genetics , Candidiasis/transmission , Female , Humans , Infection Control , Long-Term Care , Male , Microbial Sensitivity Tests , Middle Aged , Patient Discharge , Skilled Nursing Facilities , Whole Genome SequencingABSTRACT
BACKGROUND: Mycobacterium species, specifically M. abscessus and M. chelonae (MABs), are known to contaminate water systems and are uncommon causes of health care-associated infection, but morbidity can be significant and treatment complex. METHODS: Odontogenic MAB infections occurred in patients following pulpotomy procedures at dental clinic A from 1 January to 6 September 2016. We identified confirmed and probable cases using culture data, imaging, pathology results, and surgical findings. Epidemiologic and clinical data including demographics, symptoms, laboratory findings, treatment regimens, and outcomes were extracted. RESULTS: Of 1082 at-risk patients, 71 case patients (22 confirmed; 49 probable) were identified. Median age was 6 years. Median symptom onset was 85 days postpulpotomy. Pain and/or swelling on admission occurred in 79%. On imaging, 49 of 70 had abnormalities of the mandible or maxilla, 13 of 70 had lymphadenopathy, and 19 of 68 had pulmonary nodules. Seventy were hospitalized (average of 8.5 days). Intravenous antibiotics were administered to 32 cases for a median length of 137 days. Clofazimine was administered to 29 patients as part of their multidrug regimen. Antibiotic treatment was associated with many adverse effects. Treated children showed evidence of jaw healing with resolved/improving pulmonary nodules at 1-year follow-up. CONCLUSIONS: This is the largest outbreak of invasive MAB infections associated with a pediatric dental practice. While infections were indolent, patients suffered medical and surgical consequences of treatment, including permanent tooth loss. Identification of this outbreak led to a change in water standards for pediatric dental procedures in California. Enhanced national dental water quality standards are needed to prevent future outbreaks.
ABSTRACT
BACKGROUND: During 2009 and 2010, 2 clusters of organ transplant-transmitted Balamuthia mandrillaris, a free-living ameba, were detected by recognition of severe unexpected illness in multiple recipients from the same donor. METHODS: We investigated all recipients and the 2 donors through interview, medical record review, and testing of available specimens retrospectively. Surviving recipients were tested and treated prospectively. RESULTS: In the 2009 cluster of illness, 2 kidney recipients were infected and 1 died. The donor had Balamuthia encephalitis confirmed on autopsy. In the 2010 cluster, the liver and kidney-pancreas recipients developed Balamuthia encephalitis and died. The donor had a clinical syndrome consistent with Balamuthia infection and serologic evidence of infection. In both clusters, the 2 asymptomatic recipients were treated expectantly and survived; 1 asymptomatic recipient in each cluster had serologic evidence of exposure that decreased over time. Both donors had been presumptively diagnosed with other neurologic diseases prior to organ procurement. CONCLUSIONS: Balamuthia can be transmitted through organ transplantation with an observed incubation time of 17-24 days. Clinicians should be aware of Balamuthia as a cause of encephalitis with high rate of fatality, and should notify public health departments and evaluate transplant recipients from donors with signs of possible encephalitis to facilitate early diagnosis and targeted treatment. Organ procurement organizations and transplant centers should be aware of the potential for Balamuthia infection in donors with possible encephalitis and also assess donors carefully for signs of neurologic infection that may have been misdiagnosed as stroke or as noninfectious forms of encephalitis.
Subject(s)
Amebiasis , Balamuthia mandrillaris , Encephalitis , Kidney Transplantation/adverse effects , Liver Transplantation/adverse effects , Adult , Amebiasis/diagnostic imaging , Amebiasis/pathology , Amebiasis/transmission , Brain/diagnostic imaging , Brain/parasitology , Brain/pathology , Child , Child, Preschool , Encephalitis/diagnostic imaging , Encephalitis/pathology , Female , Humans , Male , Middle Aged , Tissue Donors , Transplant RecipientsABSTRACT
We surveyed infection prevention programs in 16 hospitals for hospital-associated methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, extended-spectrum ß-lactamase, and multidrug-resistant Acinetobacter acquisition, as well as hospital-associated MRSA bacteremia and Clostridium difficile infection based on defining events as occurring >2 days versus >3 days after admission. The former resulted in significantly higher median rates, ranging from 6.76% to 45.07% higher.
Subject(s)
Acinetobacter Infections/diagnosis , Bacteremia/diagnosis , Carrier State/diagnosis , Clostridioides difficile , Cross Infection/diagnosis , Enterocolitis, Pseudomembranous/diagnosis , Practice Guidelines as Topic , Staphylococcal Infections/diagnosis , Acinetobacter , Acinetobacter Infections/epidemiology , Bacteremia/epidemiology , Bacteremia/microbiology , California , Carrier State/epidemiology , Carrier State/microbiology , Cross Infection/epidemiology , Cross Infection/microbiology , Drug Resistance, Multiple, Bacterial , Enterocolitis, Pseudomembranous/epidemiology , Enterocolitis, Pseudomembranous/microbiology , Humans , Methicillin-Resistant Staphylococcus aureus , Prospective Studies , Staphylococcal Infections/epidemiology , Staphylococcal Infections/microbiology , Time Factors , Vancomycin-Resistant Enterococci , beta-Lactam ResistanceABSTRACT
OBJECTIVE: To evaluate whether an ecologic inverse association exists between methicillin-susceptible Staphylococcus aureus (MSSA) prevalence and methicillin-resistant S. aureus (MRSA) prevalence in nursing homes. METHODS: We conducted a secondary analysis of a prospective cross-sectional study of S. aureus prevalence in 26 nursing homes across Orange County, California, from 2008-2011. Admission prevalence was assessed using bilateral nares swabs collected from all new residents within 3 days of admission until 100 swabs were obtained. Point prevalence was assessed from a representative sample of 100 residents. Swab samples were plated on 5% sheep blood agar and Spectra MRSA chromogenic agar. If MRSA was detected, no further tests were performed. If MRSA was not detected, blood agar was evaluated for MSSA growth. We evaluated the association between MRSA and MSSA admission and point prevalence using correlation and linear regression testing. RESULTS: We collected 3,806 total swabs. MRSA and MSSA admission prevalence were not correlated (r = -0.40, P = .09). However, MRSA and MSSA point prevalence were negatively correlated regardless of whether MSSA prevalence was measured among all residents sampled (r = -0.67, P = .0002) or among those who did not harbor MRSA (r = -0.41, P = .04). This effect persisted in regression models adjusted for the percentage of residents with diabetes (ß = -0.73, P = .04), skin lesions (ß = -1.17, P = .002), or invasive devices (ß = -1.4, P = .0006). CONCLUSIONS: The inverse association between MRSA and MSSA point prevalence and minimal association on admission prevalence suggest MSSA carriage may protect against MRSA acquisition in nursing homes. The minimal association on admission prevalence further suggests competition may occur during nursing home stays.
Subject(s)
Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections/microbiology , Aged , Aged, 80 and over , California/epidemiology , Carrier State/epidemiology , Carrier State/immunology , Carrier State/microbiology , Cross-Sectional Studies , Female , Humans , Male , Methicillin-Resistant Staphylococcus aureus/immunology , Middle Aged , Nasal Cavity/microbiology , Nursing Homes/statistics & numerical data , Prevalence , Prospective Studies , Staphylococcal Infections/epidemiology , Staphylococcal Infections/immunology , Staphylococcus aureus/immunologyABSTRACT
We assessed characteristics associated with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) carriage among residents of 22 nursing homes. Of MRSA-positive swabs, 25% (208/824) were positive for CA-MRSA. Median facility CA-MRSA percentage was 22% (range, 0%-44%). In multivariate models, carriage was associated with age less than 65 years (odds ratio, 1.2; P<.001) and Hispanic ethnicity (odds ratio, 1.2; P=.006). Interventions are needed to target CA-MRSA.
Subject(s)
Carrier State/epidemiology , Methicillin-Resistant Staphylococcus aureus , Nursing Homes , Staphylococcal Infections/epidemiology , Age Factors , Aged , California/epidemiology , Carrier State/ethnology , Carrier State/microbiology , Community-Acquired Infections/epidemiology , Community-Acquired Infections/ethnology , Community-Acquired Infections/microbiology , Female , Hispanic or Latino/statistics & numerical data , Humans , Male , Middle Aged , Multivariate Analysis , Nose/microbiology , Odds Ratio , Prevalence , Staphylococcal Infections/ethnology , Staphylococcal Infections/microbiologyABSTRACT
We calculated hospital-onset methicillin-resistant Staphylococcus aureus (HO-MRSA) rates for Orange County, California, hospitals using survey and state data. Numerators were variably defined as HO-MRSA occurring more than 48 hours (37%), more than 2 days (30%), and more than 3 days (33%) postadmission. Survey-reported denominators differed from state-reported patient-days. Numerator and denominator choices substantially impacted HO-MRSA rates.
Subject(s)
Cross Infection/epidemiology , Methicillin-Resistant Staphylococcus aureus/isolation & purification , Staphylococcal Infections/epidemiology , Bias , California/epidemiology , Health Care Surveys , HumansABSTRACT
BACKGROUND: MRSA prevalence in nursing homes often exceeds that in hospitals, but reasons for this are not well understood. We sought to measure MRSA burden in a large number of nursing homes and identify facility characteristics associated with high MRSA burden. METHODS: We performed nasal swabs of residents from 26 nursing homes to measure MRSA importation and point prevalence, and estimate transmission. Using nursing home administrative data, we identified facility characteristics associated with MRSA point prevalence and estimated transmission risk in multivariate models. RESULTS: We obtained 1,649 admission and 2,111 point prevalence swabs. Mean MRSA point prevalence was 24%, significantly higher than mean MRSA admission prevalence, 16%, (paired t-test, p<0.001), with a mean estimated MRSA transmission risk of 16%.In multivariate models, higher MRSA point prevalence was associated with higher admission prevalence (p=0.005) and higher proportions of residents with indwelling devices (p=0.01). Higher estimated MRSA transmission risk was associated with higher proportions of residents with diabetes (p=0.01) and lower levels of social engagement (p=0.03). CONCLUSIONS: MRSA importation was a strong predictor of MRSA prevalence, but MRSA burden and transmission were also associated with nursing homes caring for more residents with chronic illnesses or indwelling devices. Frequent social interaction among residents appeared to be protective of MRSA transmission, suggesting that residents healthy enough to engage in group activities do not incur substantial risks of MRSA from social contact. Identifying characteristics of nursing homes at risk for high MRSA burden and transmission may allow facilities to tailor infection control policies and interventions to mitigate MRSA spread.
Subject(s)
Cross Infection/epidemiology , Cross Infection/transmission , Methicillin-Resistant Staphylococcus aureus/isolation & purification , Nursing Homes , Staphylococcal Infections/epidemiology , Staphylococcal Infections/transmission , Adolescent , Adult , Aged , Aged, 80 and over , Carrier State/epidemiology , Carrier State/microbiology , Carrier State/transmission , Child , Child, Preschool , Cross Infection/microbiology , Female , Humans , Infant , Male , Middle Aged , Nose/microbiology , Risk Factors , Staphylococcal Infections/microbiology , Young AdultABSTRACT
Performance of indirect fluorescent antibody (IFA) assays and rapid influenza diagnostic tests (RIDT) during the 2009 H1N1 pandemic was evaluated, along with the relative effects of age and illness severity on test accuracy. Clinicians and laboratories submitted specimens on patients with respiratory illness to public health from April to mid October 2009 for polymerase chain reaction (PCR) testing as part of pandemic H1N1 surveillance efforts in Orange County, CA; IFA and RIDT were performed in clinical settings. Sensitivity and specificity for detection of the 2009 pandemic H1N1 strain, now officially named influenza A(H1N1)pdm09, were calculated for 638 specimens. Overall, approximately 30% of IFA tests and RIDTs tested by PCR were falsely negative (sensitivity 71% and 69%, respectively). Sensitivity of RIDT ranged from 45% to 84% depending on severity and age of patients. In hospitalized children, sensitivity of IFA (75%) was similar to RIDT (84%). Specificity of tests performed on hospitalized children was 94% for IFA and 80% for RIDT. Overall sensitivity of RIDT in this study was comparable to previously published studies on pandemic H1N1 influenza and sensitivity of IFA was similar to what has been reported in children for seasonal influenza. Both diagnostic tests produced a high number of false negatives and should not be used to rule out influenza infection.
Subject(s)
Fluorescent Antibody Technique/standards , Influenza A Virus, H1N1 Subtype/genetics , Influenza, Human/diagnosis , Molecular Diagnostic Techniques/standards , Polymerase Chain Reaction/standards , Adult , California/epidemiology , Child , Child, Preschool , False Negative Reactions , False Positive Reactions , Fluorescent Antibody Technique/methods , Humans , Influenza, Human/epidemiology , Influenza, Human/virology , Inpatients/statistics & numerical data , Middle Aged , Molecular Diagnostic Techniques/methods , Outpatients/statistics & numerical data , Pandemics , Polymerase Chain Reaction/methods , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
Murine typhus is typically a mild febrile illness caused by Rickettsia typhi, generally conï¬ned to Texas and Southern California. Clinicians should consider early treatment with doxycycline when presented with a child having protracted fever, rash, and headache.We present 5 pediatric cases and a literature review highlighting the changing epidemiology and diagnostic difï¬culty of typhus.
Subject(s)
Rickettsia typhi/isolation & purification , Typhus, Endemic Flea-Borne/diagnosis , Typhus, Endemic Flea-Borne/epidemiology , Adolescent , Anti-Bacterial Agents/therapeutic use , California/epidemiology , Child, Preschool , Cluster Analysis , Doxycycline/therapeutic use , Humans , Typhus, Endemic Flea-Borne/drug therapy , Typhus, Endemic Flea-Borne/pathologyABSTRACT
BACKGROUND: Regional healthcare facility surveys to quantitatively assess nosocomial infection rates are important for confirming standardized data collection and assessing health outcomes in the era of mandatory reporting. This is particularly important for the assessment of infection control policies and healthcare associated infection rates among hospitals. However, the success of such surveys depends upon high participation and representativeness of respondents. METHODS: This descriptive paper provides methodologies that may have contributed to high participation in a series of administrative, infection control, and microbiology laboratory surveys of all 31 hospitals in a large southern California county. We also report 85% (N = 72) countywide participation in an administrative survey among nursing homes in this same area. RESULTS: Using in-person recruitment, 48% of hospitals and nursing homes were recruited within one quarter, with 75% recruited within three quarters. CONCLUSIONS: Potentially useful strategies for successful recruitment included in-person recruitment, partnership with the local public health department, assurance of anonymity when presenting survey results, and provision of staff labor for the completion of detailed survey tables on the rates of healthcare associated pathogens. Data collection assistance was provided for three-fourths of surveys. High compliance quantitative regional surveys require substantial recruitment time and study staff support for high participation.
Subject(s)
Cross Infection/prevention & control , Health Care Surveys/methods , Infection Control/standards , Nursing Homes/standards , Adolescent , Adult , Aged , Bacterial Infections/prevention & control , California , Child , Child, Preschool , Cross Infection/microbiology , Delivery of Health Care/standards , Female , Health Facilities/standards , Humans , Male , Middle Aged , Public Health/standards , Reproducibility of Results , Surveys and QuestionnairesABSTRACT
An 11-year-old boy with serologically confirmed Chlamydophila pneumoniae infection presented with clinical, laboratory, and echocardiographic changes consistent with myopericarditis. No reports on C. pneumoniae myopericarditis in children are found in the medical literature. The boy, previously healthy, presented with fever, rash, constitutional symptoms, elevated acute phase reactants, elevated cardiac enzymes, and high brain natriuretic peptide levels. Hemodynamic instabilities, including hypotension and mild hypoxia, were noted. Two-dimensional echocardiographic findings showed mildly depressed left ventricular systolic function and small pericardial effusion. Requiring inotropic support, the boy was treated with azithromycin 10 mg/kg once daily for 7 days and a single dose of intravenous immunoglobulin 2 g/kg. He recovered fully with improved left ventricular systolic function before hospital discharge. An early definitive diagnosis is essential to knowing the etiology of pediatric myocarditis. Specific therapy may play role in the management and prognosis of this disorder.
Subject(s)
Chlamydophila Infections/microbiology , Chlamydophila pneumoniae/isolation & purification , Myocarditis/microbiology , Pericarditis/microbiology , Anti-Bacterial Agents/therapeutic use , Antibodies, Bacterial/analysis , Azithromycin/therapeutic use , Child , Chlamydophila Infections/diagnosis , Chlamydophila Infections/drug therapy , Chlamydophila pneumoniae/immunology , Diagnosis, Differential , Drug Therapy, Combination , Echocardiography , Follow-Up Studies , Humans , Immunoglobulins, Intravenous/therapeutic use , Immunologic Factors/therapeutic use , Male , Myocarditis/diagnosis , Myocarditis/drug therapy , Pericarditis/diagnosis , Pericarditis/drug therapy , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Influenza surveillance is valuable for monitoring trends in influenza-related morbidity and mortality. Using the 2005-2006 influenza season as an example, this paper describes a comprehensive influenza surveillance program used by the California Department of Public Health (CDPH). METHODS: Data collected from patients evaluated for acute respiratory illness in a given week were reported and summarized the following week, including (1) electronic hospital pneumonia and influenza admission and antiviral usage records from Kaiser Permanente, (2) sentinel provider influenza-like illness (ILI) reports, (3) severe pediatric influenza case reports (e.g., children either hospitalized in intensive care or expired), (4) school clinic ILI evaluations, and (5) positive influenza test results from a network of academic, hospital, commercial, and public health laboratories and the state CDPH Viral and Rickettsial Disease Laboratory. RESULTS: Influenza activity in California in the 2005-2006 season was moderate in severity; all clinical and laboratory markers rose and fell consistently. Extensive laboratory characterization identified the predominant circulating virus strain as A/California/7/2004(H3N2), which was a component of the 2005-2006 influenza vaccine; 96% of samples tested showed adamantane resistance. CONCLUSIONS: By using multiple, complementary surveillance methods coupled with a strong laboratory component, the CDPH has developed a simple, flexible, stable, and widely accepted influenza surveillance system that can monitor trends in statewide influenza activity, ascertain the correlation between circulating strains with vaccine strains, and assist with detection of new strain variants. The methods described can serve as a model for influenza surveillance in other states.
Subject(s)
Alphainfluenzavirus/isolation & purification , Influenza, Human/epidemiology , Population Surveillance/methods , Seasons , California/epidemiology , Humans , Influenza, Human/mortality , Models, OrganizationalABSTRACT
Relatively few pediatric West Nile virus cases have been recognized in the United States since the virus was first identified in 1999. We reviewed the clinical characteristics of 23 cases in pediatric patients that occurred in California in 2004 to better understand the infection in this population.
Subject(s)
West Nile Fever/physiopathology , Adolescent , California , Child , Child, Preschool , Encephalitis, Viral/physiopathology , Female , Humans , Immunocompromised Host , Male , Meningitis, Viral/physiopathology , Muscle Hypotonia/etiology , Paralysis/etiology , West Nile virus/isolation & purificationABSTRACT
Endometritis and toxic shock syndrome associated with Clostridium sordellii have previously been reported after childbirth and, in one case, after medical abortion. We describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that occurred within one week after medically induced abortions. Clinical findings included tachycardia, hypotension, edema, hemoconcentration, profound leukocytosis, and absence of fever. These cases indicate the need for physician awareness of this syndrome and for further study of its association with medical abortion.
Subject(s)
Abortifacient Agents/adverse effects , Abortion, Induced/adverse effects , Clostridium Infections/etiology , Clostridium sordellii , Mifepristone/adverse effects , Misoprostol/adverse effects , Shock, Septic/etiology , Abdominal Pain/etiology , Adolescent , Adult , Clostridium Infections/diagnosis , Clostridium sordellii/genetics , Clostridium sordellii/isolation & purification , Diagnosis, Differential , Endometritis/microbiology , Fatal Outcome , Female , Humans , Hypotension/etiology , Polymerase Chain Reaction , Pregnancy , Pregnancy Trimester, First , RNA, Ribosomal, 16S/isolation & purification , Shock, Septic/diagnosis , Shock, Septic/microbiology , Tachycardia/etiology , Uterus/microbiology , Uterus/pathology , Vomiting/etiologyABSTRACT
Giant brain abscesses have become a rarity in North American pediatric neurosurgery practice. A high index of suspicion and readily available noninvasive brain imaging have made the diagnosis of brain abscess easier and more prompt than in past decades. There are complicating factors, however, that may delay a timely diagnosis and allow the disease to progress to extremes before becoming evident. Children with hydrocephalus and ventricular shunts can harbor large abscesses. As the volume of purulent material expands, cerebrospinal fluid can be forced down the shunt system, reducing the intracranial pressure (ICP), at least for a time. Infants are typically more tolerant of an expanding mass lesion, allowing considerable time to pass before symptoms of increased ICP manifest. The authors report two cases of brain abscess, which achieved giant dimensions before the children became symptomatic. The pathogens were found to be Gram negative and of several species. The properties of these Gram-negative pathogens to create abscess and the clinical circumstances, including the presence of meningitis and ventricular shunts, which contributed to the process, are explored.
Subject(s)
Brain Abscess/diagnosis , Brain Abscess/microbiology , Gram-Negative Bacterial Infections/complications , Adolescent , Brain Abscess/pathology , Brain Abscess/surgery , Diagnosis, Differential , Humans , Hydrocephalus/therapy , Infant , Intracranial Pressure , Male , Severity of Illness Index , Ventriculoperitoneal ShuntABSTRACT
BACKGROUND: Aseptic meningitis associated with urinary tract infection (UTI) in young infants has not been described in detail in the literature. We performed a retrospective study to determine the incidence and clinical features of aseptic meningitis accompanying UTI. METHODS: We retrospectively reviewed the medical records of all infants younger than 6 months of age hospitalized with a UTI at Miller Children's Hospital from March 1995 through March 2000. UTI was defined as a urine culture growing > or =10,000 colony-forming units/ml of a single organism from a catheterized specimen or > or =100,000 colony-forming units/ml of a single organism from a bagged urine specimen. Meningitis was defined as a positive cerebrospinal fluid culture or cerebrospinal fluid with >35 white blood cells/mm3 in infants < or =30 days of age or with >10 white blood cells/mm3 in infants >30 days of age. RESULTS: Of 386 infants with UTI, a lumbar puncture was performed in 260, and 31 (11.9%) had aseptic meningitis. One infant had bacterial meningitis. None of the 26 infants with UTI and bacteremia had aseptic meningitis. Two infants with meningitis had confirmed enteroviral infections, but aseptic meningitis did not occur more frequently in any particular month or during times of peak enteroviral activity. CONCLUSIONS: A cerebrospinal fluid pleocytosis is relatively common in hospitalized infants <6 months of age who have a UTI and usually does not reflect bacterial meningitis. Knowledge of this may prevent unnecessary courses of antibiotics for presumed bacterial meningitis and lead to evaluation for other possible causes of aseptic meningitis including viral or congenital infections.