A review of human thermal comfort model in predicting human-environment interaction in non-uniform environmental conditions.

This paper presented a review of the literature on the human thermal comfort model, which can be employed to predict the response of a human towards the environmental surroundings. An important premise of this paper is that governments in tropical regions have taken proactive action in minimizing energy consumption by air-conditioning through elevated room temperature. However, would such an action worsen the quality of interior conditions, particularly the thermal comfort? To answer this question, developing a human thermal comfort model under stratum ventilation mode can become a reference model for air-conditioning system design in all tropical buildings and indirectly reduce the emission of carbon dioxide (CO2) from heating, ventilation, and air-conditioning (HVAC) system that caused a warmer environment. For this purpose, there are two critical processes to identify the role of human thermal comfort, namely human reaction towards the thermal ambient (thermoregulation) and the heat transfer and air movement that occur in the enclosed space due to natural and forced convection.

Phenotyping of hypertensive heart disease and hypertrophic cardiomyopathy using personalized 3D modelling and cardiac cine MRI.

Differential diagnosis of hypertensive heart disease (HHD) and hypertrophic cardiomyopathy (HCM) is clinically challenging but important for treatment management. This study aims to phenotype HHD and HCM in 3D + time domain by using a multiparametric motion-corrected personalized modeling algorithm and cardiac magnetic resonance (CMR). 44 CMR data, including 12 healthy, 16 HHD and 16 HCM cases, were examined. Multiple CMR phenotype data consisting of geometric and dynamic variables were extracted globally and regionally from the models over a full cardiac cycle for comparison against healthy models and clinical reports. Statistical classifications were used to identify the distinctive characteristics and disease subtypes with overlapping functional data, providing insights into the challenges for differential diagnosis of both types of disease. While HCM is characterized by localized extreme hypertrophy of the LV, wall thickening/contraction/strain was found to be normal and in sync, though it was occasionally exaggerated at normotrophic/less severely hypertrophic regions during systole to preserve the overall ejection fraction (EF) and systolic functionality. Additionally, we observed that hypertrophy in HHD could also be localized, although at less extreme conditions (i.e. more concentric). While fibrosis occurs mostly in those HCM cases with aortic obstruction, only minority of HHD patients were found affected by fibrosis. We demonstrate that subgroups of HHD (i.e. preserved and reduced EF: HHDpEF & HHDrEF) have different 3D + time CMR characteristics. While HHDpEF has cardiac functions in normal range, dilation and heart failure are indicated in HHDrEF as reflected by low LV wall thickening/contraction/strain and synchrony, as well as much reduced EF.