ABSTRACT
INTRODUCTION: Massive localized lymphedema is an aggressive type of lymphedema that causes great functional impairment for the patient, depriving from one's basic life activities. The treatment of this type of lesion is eminently surgical, requiring ablative surgery (complete surgical resection of the lesion), but the possible techniques not always provide a good functional result. PRESENTATION OF CASE: We reported a case of a penoscrotal massive lymphedema treated by our Body Contour Group/Plastic surgery department of our institute. We performed the resection of the giant penoscrotal lesion, used a posterior scrotal flap for defect's reconstruction and a split-thickness skin graft for penis' body reconstruction, closed with Z-plasty. DISCUSSION: Contrary to what the literature says, we prefer to use the split-thickness skin graft to reconstruct the penis' body in these cases, against local flaps. According to our experience with some similar cases, this technique provides a better functional result once it allows the penis to a better expansion during erection. The key maneuver to avoid contracture of the graft and retraction of the penis is to perform a broken line suture (Z-plasty) in the topography of the median raphe. CONCLUSION: In cases of penoscrotal massive lymphedema, the treatment's option with better results is the surgical one. The use of a scrotal flap associated with split-thickness skin graft for penis provides good aesthetic and functional outcomes.
ABSTRACT
Surgical treatment of the wounds includes a variety of procedures ranging from débridement to complex procedures such as use of free flaps using microsurgical techniques. Often surgery is important for closing of a chronic wound or a complex wound. These procedures include preoperative evaluation and proper decision on which type of coverage will be usedthat may be grafts, local flaps or free flaps...
O tratamento cirúrgico das feridas inclui uma série de procedimentos que vão desde o desbridamento até os procedimentos complexos como a utilização de retalhos livres utilizando técnicas microcirurgicas. Muitas vezes o tratamento cirúrgico é indispensável para o fechamento de uma ferida crônica ou uma ferida complexa. Estes procedimentos incluem a avaliação pré operatória adequada e a decisão de qual tipo de cobertura vai ser utilizado,podendo ser enxertos, retalhos locais ou retalhos livres...
Subject(s)
Humans , Wounds and Injuries/surgery , Wounds and Injuries/diagnosis , Surgical Flaps , Skin Ulcer/surgeryABSTRACT
OBJECTIVES: Analyze the octogenarians patients submitted to the surgical myocardium revascularization (CABG) with and without extracorporeal comparing the clinical outcomes and its survival curves. METHODS: Observational study of the cohort type involving 396 octogenarians submitted to the CABG between 01/01/ 2000 and 01/01/2007. Elaboration of an itinerary for collection of data of the handbooks containing 36 variables. Comparison between groups using t test for independent samples, chisquare and survival curves using Kaplan Meier. RESULTS: We analyzed 290 patients that possessed appropriate information. The first group G1, of the patients operated without extracorporeal, was constituted of 111 patients and the second group G2, of the operated ones with extracorporeal was constituted of 179 patients. The univariate analyzes had presented statistics significance for the variables: cardiac insufficiency functional class preoperative (P=0.000), tobacco smoking (P=0.050), number of performed grafts (P=0.050), graft type (P=0,000), associates procedures (P=0.000), preoperative use of intra-aortic balloon (P=0.000), hospital mortality (P=0.000) and type of death (P=0.020). In the postoperative outcomes stroke (P=0,036), re-internment for angina (P=0,038). The analyze of the survival curves presented statistic difference (P=0,009). CONCLUSIONS: Hospital mortality and stroke were bigger in the G2 In the long time the patients of the G1 had respectively presented greater number of re-internments for angina and the late mortality was larger in G2 for the largest prevalence of cardiac deaths.
Subject(s)
Cardiopulmonary Bypass , Coronary Artery Bypass/methods , Heart Diseases/surgery , Stroke/epidemiology , Aged, 80 and over , Cardiopulmonary Bypass/adverse effects , Cardiopulmonary Bypass/mortality , Coronary Artery Bypass/mortality , Epidemiologic Methods , Female , Heart Diseases/mortality , Hospital Mortality , Humans , Male , Time Factors , Treatment OutcomeABSTRACT
OBJETIVO: Comparar os desfechos clínicos nos pacientes octogenários submetidos à revascularização cirúrgica do miocárdio com e sem a utilização de circulação extracorpórea. MÉTODOS: Estudo de coorte histórico com pacientes octogenários operados no InCor no período entre 1/1/2000 e 1/1/2007, divididos em dois grupos: G1 constituído por 111 pacientes operados sem circulação extracorpórea (CEC) e G2 com 179 operados com CEC. Foram analisadas 36 variáveis utilizando-se o teste t de Student, qui quadrado e as curvas de sobrevida pelo método de Kaplan-Meier; Nível de significância de 5 por cento. RESULTADOS: Na análise univariada apresentaram significância: insuficiência cardíaca congestiva préoperatória (P=0,000), tabagismo (P=0,050), número de enxertos realizados (P=0,050), tipo de enxerto (P=0,000), procedimentos associados (P=0,000), uso de balão intraaórtico no pós-operatório (P=0,000), óbito hospitalar (P=0,000) e tipo de morte (P=0,020). No pós-operatório imediato, foi significativa apenas a incidência de acidente vascular cerebral (AVC) no G2 (P = 0,036). A longo prazo tivemos maior incidência de reinternação por angina (P=0,038) no G1. A análise das curvas de sobrevida apresentou diferença estatística (P=0,009; Log-Rank Test). CONCLUSÃO: A revascularização do miocárdio sem CEC, nesta série, mostrou ser vantajosa para o paciente octogenário a curto prazo, pois os pacientes apresentaram menor índice de AVC no pós-operatório mediato, enquanto a longo prazo houve maior número de reinternação por angina no G1 e uma mortalidade maior no G2.
OBJECTIVES: Analyze the octogenarians patients submitted to the surgical myocardium revascularization (CABG) with and without extracorporeal comparing the clinical outcomes and its survival curves. METHODS: Observational study of the cohort type involving 396 octogenarians submitted to the CABG between 01/01/ 2000 and 01/01/2007. Elaboration of an itinerary for collection of data of the handbooks containing 36 variables. Comparison between groups using t test for independent samples, chisquare and survival curves using Kaplan Meier. RESULTS: We analyzed 290 patients that possessed appropriate information. The first group G1, of the patients operated without extracorporeal, was constituted of 111 patients and the second group G2, of the operated ones with extracorporeal was constituted of 179 patients. The univariate analyzes had presented statistics significance for the variables: cardiac insufficiency functional class preoperative (P=0.000), tobacco smoking (P=0.050), number of performed grafts (P=0.050), graft type (P=0,000), associates procedures (P=0.000), preoperative use of intra-aortic balloon (P=0.000), hospital mortality (P=0.000) and type of death (P=0.020). In the postoperative outcomes stroke (P=0,036), re-internment for angina (P=0,038). The analyze of the survival curves presented statistic difference (P=0,009). CONCLUSIONS: Hospital mortality and stroke were bigger in the G2 In the long time the patients of the G1 had respectively presented greater number of re-internments for angina and the late mortality was larger in G2 for the largest prevalence of cardiac deaths.
Subject(s)
Aged, 80 and over , Female , Humans , Male , Cardiopulmonary Bypass , Coronary Artery Bypass/methods , Heart Diseases/surgery , Stroke/epidemiology , Cardiopulmonary Bypass/adverse effects , Cardiopulmonary Bypass/mortality , Coronary Artery Bypass/mortality , Epidemiologic Methods , Hospital Mortality , Heart Diseases/mortality , Time Factors , Treatment OutcomeABSTRACT
Breast cancer stem cells (CSC) have been postulated recently as responsible for failure of breast cancer treatment. The purpose of this study is to review breast CSCs molecular biology with respect to their mechanism of resistance to conventional therapy, and to develop treatment strategies that may improve survival of breast cancer patients. A literature search has identified in vitro and in vivo studies of breast CSCs. Breast CSCs overexpress breast cancer resistance protein (BCRP) which allows cancer cells to transport actively chemotherapy agents out of the cells. Radioresistance is modulated through activation of Wnt signaling pathway and overexpression of genes coding for glutathione. Lapatinib can selectively target HER-2 positive breast CSCs and improves disease-free survival in these patients. Metformin may target basal type breast CSCs. Parthenolide and oncolytic viruses are promising targeting agents for breast CSCs. Future clinical trials for breast cancer should include anti-cancer stem cells targeting agents in addition to conventional chemotherapy. Hypofractionation radiotherapy may be indicated for residual disease post chemotherapy.
Subject(s)
Breast Neoplasms/pathology , Drug Resistance, Neoplasm/physiology , Neoplastic Stem Cells/pathology , Radiation Tolerance/physiology , Signal Transduction/physiology , Antineoplastic Agents/metabolism , Antineoplastic Agents/therapeutic use , Breast Neoplasms/metabolism , Breast Neoplasms/therapy , Drug Delivery Systems/methods , Drug Delivery Systems/trends , Female , Humans , Molecular Biology/methods , Molecular Biology/trends , Neoplastic Stem Cells/drug effects , Neoplastic Stem Cells/radiation effects , Oncolytic Viruses/metabolism , Signal Transduction/drug effects , Signal Transduction/radiation effectsABSTRACT
PURPOSE: To investigate two-dimensional (2D) radiograph-based plans using three-dimensional (3D) dose-volume histogram (DVH) parameters following guidelines from Gynecologic GEC-ESTRO Working Group (GEC-ESTRO). METHODS AND MATERIALS: Nineteen high-dose-rate (HDR) fractions from 8 patients were studied. Prescription was 45 Gy from external beam radiation therapy plus 30 Gy in five fractions from HDR using tandem and ring/ovoids. Both radiographs and CT scan were obtained. Treatment was planned using radiographs following American Brachytherapy Society (ABS) guidelines. Retrospective evaluation of above 2D plans on a 3D volumetric basis was achieved by generating CT image-based 3D plans using same dwell times. RESULTS: In 2D plans, International Commission on Radiation Units and Measurement (ICRU) bladder and rectal point doses were 3.8+/-0.4 and 3.0+/-0.5 Gy, respectively. In 3D plans, rectum D(2 cc) is 4.0+/-1.0 Gy and bladder D(2 cc) is 5.4+/-0.9 Gy. Position of actual hottest spot in 3D rectum volume was close to the position of ICRU rectal point. ICRU bladder point did not match with the actual hottest spot in 3D bladder volume. In 2D plans, H-point dose was 5.8+/-0.2 Gy. In 3D plans, dose to CT-based cervix (D(90)) reduced from 7.1 to 4.2 Gy as the cervical volume increased from 12 to 39 cc. Average D(2 cc)/ICRU dose ratio was calculated to be 1.36/1.01 for bladder/rectum, respectively. CONCLUSIONS: The DVH analysis of 2D plans revealed a suboptimal coverage of CT-based cervix and a negative correlation between coverage and cervical size. Rectum dose to 2 cc weakly correlated with ICRU point dose. Currently published constraint for bladder in 3D planning is tighter than ABS guidelines in past 2D planning.
