Assessment of cardiac function in children with congenital adrenal hyperplasia: a case control study in Cameroon.

BACKGROUND: High level of androgens found in congenital adrenal hyperplasia (CAH) seems to have a deleterious effect on heart function. We therefore evaluate cardiac function of children with CAH in comparison with a healthy group. METHODS: We carried out a case-control study in the single endocrinology unit of the Mother and Child Center of Chantal Biya's Foundation. Cases were matched for age and genotypic sex to 2 healthy controls. We analyzed the ejection fraction (LVEF), fractional shortening and left ventricular mass; output and cardiac index; E and A waves velocities, E/A ratio and the mitral deceleration time and diameter of the left atrium; tricuspid annular plane systolic excursion and pulmonary artery systolic pressure were also measured. RESULTS: We included 19 patients with a median age of 6.26 ± 3.75 years and 38 controls stackable distribution. The left ventricular mass of cases was greater than that of controls. A case of reversible cardiomyopathy on hormone replacement therapy was found. For the cases, the average ejection fraction was 71.95 ± 7.88%; the average fractional shortening was 40.67 ± 7.02%. All these values ​​were higher than those of controls, although the difference was not statistically significant. Diastolic left ventricular function was more impaired among the cases. Right ventricular function was similar in both groups. These abnormalities were highly correlated to the late age at diagnosis and duration of treatment. CONCLUSION: This study shows an altered cardiac function in CAH compared to healthy control and highlights importance of an early diagnosis of cases, a tight control of androgens levels and a regular monitoring of cardiac function.

Neonatal mortality in a referral hospital in Cameroon over a seven year period: trends, associated factors and causes.

BACKGROUND: The fourth Millennium Development Goals targets reduction of the mortality rate of under-fives by 2/3 by the year 2015. This reduction starts with that of neonatal mortality representing 40% of childhood mortality. In Cameroon neonatal mortality was 31% in 2011. OBJECTIVES: We assessed the trends, associated factors and causes of neonatal deaths at the Yaounde Gynaeco-Obstetric and Pediatric Hospital. METHODS: The study was a retrospective chart review. Data was collected from the hospital records, and included both maternal and neonatal variables from 1(st) January 2004 to 31(st) December 2010. RESULTS: The neonatal mortality was 10%. Out-borns represented 49.3% of the deceased neonates with 11.3% born at home. The neonatal mortality rate followed a downward trend dropping from 12.4% in 2004 to 7.2% in 2010. The major causes of deaths were: neonatal sepsis (37.85%), prematurity (31.26%), birth asphyxia (16%), and congenital malformations (10.54%). Most (74.2%) of the deaths occurred within the first week with 35% occurring within 24 hours of life. Mortality was higher in neonates with birth weight less than 2500 g and a gestational age of less than 37 weeks. In the mothers, it was high in single parenthood, primiparous and in housewives and students.. CONCLUSION: There has been a steady decline of neonatal mortality since 2004. Neonatal sepsis, prematurity, birth asphyxia and congenital malformations were the major causes of neonatal deaths. Neonatal sepsis remained constant although at lower rates over the study period.

[Factors associated with the survival of very low birth weight neonates at the Yaounde gynaeco-obstetric and pediatric hospital, Cameroon]. / Facteurs associés à la survie des nouveau-nés de très faible poids de naissance à l'hôpital gynéco-obstétrique et pédiatrique de Yaoundé, Cameroun.

OBJECTIVES: The rate of survival of very low birth weight neonates (less than 1500 g) is still low in most developing countries, such as Cameroon. The aim of this study was to assess the maternal and neonatal factors that can influence the survival of neonates with birth weights under 1500 g. MATERIAL AND METHODS: This was a retrospective, descriptive, and analytic study of 397 neonates weighing less than 1500 g who were admitted to the Yaounde gynaeco-obstetric and pediatric hospital from May 2003 to December 2011. The chi-squared test and the odds ratio were used to identify risk factors for death. The threshold of significance was P<0.05. RESULTS: The overall survival rate was 26.5%. The main comorbidities were prematurity (99%), neonatal sepsis (36%), and intrauterine growth retardation (27.2%). The factors that statistically influenced outcome were: parity, birth weight, gestational age, the 5th-min Apgar score, advanced resuscitation at birth, and respiratory distress. CONCLUSION: The survival of neonates weighing less than 1500 g depends on several factors, which if acted upon could improve the survival rate.

[Pasteurella multocida meningitis with cerebral abscesses]. / Méningite à Pasteurella multocida compliquée d'abcès cérébral.

Pasteurella multocida is classically responsible for local soft tissue infections secondary to dog bites or cat scratches. It can be responsible for meningitis in infants and elderly persons. We report the case history of a 5-year-old male child admitted to our pediatric unit for meningitis. Cerebrospinal fluid analysis revealed an infection with P. multocida. The suspected mode of contamination was either from the saliva of a pet dog or through an unnoticed skull fracture sustained after an accident 1 year prior to the occurrence of meningitis. In spite of the neurologic complication (cerebral abscess), the progression was favorable after drainage of the abscess, 5 weeks of parenteral treatment, and 3 weeks of oral antibiotic therapy. Meningitis due to Pasteurella sp. is rare and can lead to neurologic complications. The notion of bites or scratches can be absent and the mode of contamination is sometimes difficult to unveil.

[Clinical and etiological aspects of focal epilepsy in children at Yaoundé Gynaeco-obstetric Hospital (Cameroon)]. / Aspects cliniques et etiologiques de l'epilepsie focale de l'enfant a l'hopital Gyneco-obstetrique et pediatrique de Yaounde (Cameroun).

OBJECTIVE: To describe the clinical and etiological aspects of child focal epilepsy at Yaoundé Gynaeco-Obstetric and Pediatric Hospital (YGOPH) in Cameroon. PATIENTS AND METHODS: It was a cross-sectional descriptive study carried out in pediatric neurology and epileptology unit of YGOPH from October 1st 2011 to March 30th 2012. We included 218 patients aged 0-16 years with a diagnosis of focal epilepsy in whom an electroencephalogram (EEG) was performed. The studied variables were epidemiological, etiological factors, type of epilepsy, EEG abnormalities, abnormalities in brain CT-scan, and probable etiology. RESULTS: The sex ratio was 1.34 M/1F. The mean age of patients was 8 ± 4 years. In 58.71% (128/218) the onset of crises was before the age of five and decreased gradually until adolescence. The EEG showed an epileptic focus in 161 patients (73.85%). The main foci were centro-temporal (19.9%), frontal (19.2%), temporal (14.9%) and fronto-temporal (14.9%). The CT-scan was abnormal in 58 (56.86%) of 102 patients, who performed head CT-scan, with as major abnormalities, brain atrophy and after-effects lesions. Etiological factors were found in 76.15 % of patients, it was mainly neonatal asphyxia (21%), family history of epilepsy (20.6%) and febrile seizures (19.7%). Focal epilepsies were of structural (51.4%), genetic (24.3%) or unknown causes. Neurological abnormalities associated were more frequently in focal epilepsies of structural causes. CONCLUSION: The focal child epilepsies are mostly of structural causes and preferentially temporal and/or frontal in location. The main etiological factors are family history of epilepsy and neonatal asphyxia.

OBJECTIF: Décrire les caractéristiques cliniques et étiologiques de l'épilepsie focale de l'enfant à l'Hôpital Gynéco-obstétrique et pédiatrique de Yaoundé (HGOPY) au Cameroun. PATIENTS ET MÉTHODE: Il s'agissait d'une étude transversale descriptive réalisée dans l'unité de neuropédiatrie et d'épileptologie de HGOPY du 1er octobre 2011 au 30 mars 2012. Elle incluait 218 patients âgés de 0 à 16 ans ayant un diagnostic d'épilepsie focale et chez qui un électroencéphalogramme (EEG) avait été réalisé. Les variables étudiées étaient les données épidémiologiques, les facteurs étiologiques, le type d'épilepsie, les anomalies EEG, les anomalies au scanner cérébral, et l'étiologie probable. RÉSULTATS: Le sex-ratio était de 1,34M/1F. L'âge moyen des patients était de 8 ± 4 ans. Les crises débutaient dans 58,71% (128/218) avant l'âge de cinq ans et diminuaient progressivement jusqu'à l'adolescence. L'EEG révélait un foyer épileptique chez 161 patients (73,85%). Les principaux foyers étaient centro-temporal (19,9%), frontal (19,2%), temporal (14,9%) et fronto-temporal (14,9%). Le scanner était pathologique chez 58 (56,86%) des 102 patients ayant fait le scanner cérébral, avec pour principales anomalies l'atrophie cérébrale et les lésions séquellaires. Les facteurs étiologiques étaient retrouvés chez 76,15% des patients; ils s'agissaient principalement de l'asphyxie néonatale (21%), des antécédents familiaux d'épilepsie (20,6%) et des convulsions fébriles (19,7%). Les épilepsies focales étaient de causes structurelles (51,4%), génétiques (24,3%) ou inconnue. Les anomalies neurologiques associées étaient plus fréquentes dans les épilepsies focales de cause structurelle. CONCLUSION: Les épilepsies focales de l'enfant sont en majorité structurelles et préférentiellement temporales et/ou frontales. Les principaux facteurs étiologiques sont les antécédents familiaux d'épilepsie et l'asphyxie néonatale..

Breastfeeding Practices by Women Attending the Vaccination and Pediatric Out-Patient Clinics at the Yaounde Gynaeco-Obstetric and Pediatric Hospital Cameroon

Despite the well-known benefits of exclusive breastfeeding in sustaining infant well-being; breastfeeding rates still remain low in many countries. We aimed at investigating the practice and determinants of exclusive breastfeeding for the first six months of life in Cameroonian women. METHODS In this cross-sectional study; we interviewed a consecutive sample of 310 mothers at the Yaounde Gynaeco-Obstretic and Pediatric. The study was conducted from 1st September 2011 to 29th February 2012. Variables related to the practice of breastfeeding within the first 6months of life were assessed. Odds ratio was used to determine the predictive variables of exclusive breastfeeding for 6 months. RESULTS The reported rates of exclusive breastfeeding were 84.8 at birth and 23.5 at six months. Medical advice (49.3) and concern for the child's health (42.5) were the two main reasons for practicing exclusive breast-feeding for the first six months of life; while resumption of studies or work (38.4) and the belief that the newborn was not 'satisfied' (34.2) were the main reasons for introducing other foods. Most children (84.5) did not receive any foods first breastfeed. Breast milk substitutes were given to 70.5 of the babies. Most women (87.1) breastfed on demand; and breast pain was the main difficulty in 60.5 of the mothers. Being a housewife was positively associated with exclusive breast-feeding (OR:2.18; 95 CI: [1.25-3.81]; P= 0.005 ). CONCLUSION Exclusive breastfeeding in the first 6 months remains low in this setting. Sensitization and education of mothers during prenatal visits and routine consultations should be reinforced

Les lymphangiomes : etude retrospective de 12 cas a Yaounde (Cameroun)

Objectif : Rechercher les donnees preliminaires sur les lymphangiomes au Cameroun; leurs topographies ainsi que leurs formes histologiques dans le but d'ameliorer le diagnostic et les modalitestherapeutiques de ces lesions. Materiel et methode : Il s'agit d'une etude retrospective; observationnelle et descriptive.Les patients ayant presente des lymphangiomes documentes par un rapport anatomopathologique ont ete recrutes consecutivement dans tous les laboratoires d'anatomie pathologique du Cameroun sur une periode de 06 ans; de 2004 a 2009. Les coupes histologiques colorees a l' hematoxyline-eosine ont ete revues pour confirmation diagnostique de differents types. Resultats : Douze cas ont ete recrutes. La moitie de ces cas provenait des malades originaires de la region de l'ouest du Cameroun. Le lymphangiome touchait le plus souvent l'enfant age de 1 a 5 ans avec predominance du type hygrome kystique. Les localisations les plus courantes etaient axillaires; cervicales et viscerales. Conclusion : Le lymphangiome constitueun desdiagnostics differentiels important de toute masse survenant chez les patients; en particulier chez les enfants ages de 1 a 5 ans.L'anatomie pathologique est d'une aide dans le diagnostic et la typisation

Our experience in the management of infantile hydrocephalus: a study on thirty-five regrouped cases in Yaounde, Cameroon.

BACKGROUND: Hydrocephalus is a frequent central nervous system disorder in children, and despite its importance, it has not been sufficiently studied in developing countries. PATIENTS AND METHODS: A prospective and descriptive study on 35 cases of infantile hydrocephalus was carried out in the neurosurgery unit of the Yaounde Central Hospital, from March 2008 to January 2010. RESULTS: The mean age of the patients was 6.69±1.58 months, and the majority of them were in the 0-6 months age group (71.43%). The most frequent causes were congenital malformations, with stenosis of the aqueduct of Sylvius being the most represented (31.43%). As radiological workup, a CT scan was done in more than half of the cases (57.15%), and ventriculo-peritoneal shunting was the main surgical method of management used (94.29%). Infectious complications were observed in 22.86% of our cases. CONCLUSION: Hydrocephalus is a frequent disorder in this Cameroonian setting affecting mostly the 0-6 months age group. For early diagnosis to be made, the head circumference of neonates should be routinely measured in the labour room and followed-up in all medical visits. To avert complications following surgery, rigorous surgical procedures with effective asepsis and appropriate methods and materials for shunting should be used.

[Mortality of neonatal surgical emergencies at the Gynecology-Obstetric and Pediatric hospital of Yaounde, Cameroon]. / Mortalité des urgences chirurgicales néonatates à l'hôpital gynéco-obstétrique et pédiatrique de Yaoundé, Cameroun.

From July 2005 to November 2009, 38 neonates with surgical emergencies died in the neonatal unit of the Gyneco Obstetric and Pediatric Hospital Yaounde. The mortality rate of these emergencies was 43.1%, and those within the age group of 1 to 7 days were the most affected with a sex ratio of 1.2. The mean delay before consultation was 3.7 days. Half of the neonates had a birth weight of less than 2,500 g and 7 cases (18.4%) were premature. A medicalised ambulance was used for transfer to our unit in only half of the neonates. The main disorders were those affecting the digestive tract in 42.1% of our series. In 50% of our cases, there were associated malformations and 28 cases (73.7%) did not undergo surgery. Malnutrition and infection were the main complications in 60% of the cases. The authors discuss this deplorable situation and suggest recommendations for improvement.

Breastfeeding practices in infants in the west region of cameroon.

BACKGROUND: The study was conducted to evaluate the knowledge, attitudes and practices of breast-feeding in the West region of Cameroon. METHODS: A cross sectional descriptive study was conducted in two health facilities on 195 mother-infant pairs, seen at the out patient and vaccination units of the Bafoussam Regional Hospital over a period of one month from 1(st) to 30(th) September 2008. The socio-demographic characteristics of mothers, knowledge on breastfeeding and the practice of breastfeeding were studied. Data was analyzed using the SPSS software. The chi square and student t- test were used for comparison and results considered significant for P< 0.05. RESULTS: Breastfeeding was practised by 99.48% of the mothers. Only 33.8% of the mothers knew that they had to exclusively breastfeed up to 6 months, and 20% effectively breastfed up to 6 months. The mean duration of breastfeeding was 5.06 months and negatively correlated with the number of children and the profession of the mother. In 69.74% of the women, nothing was given to the baby before the first breastfeed. Discontinuation of breastfeeding was done averagely around 15.24 months and earlier in married women and in those with a higher educational level. CONCLUSION: Although the majority of parents practised breast feeding, only a minority understood its benefits, so more should be done to educate the community on the benefits of exclusive breast-feeding for up to six months.

[Clinical, etiological, and therapeutic aspects of febrile convulsions. A review of 325 cases in Yaoundé]. / Aspects cliniques, étiologiques et thérapeutiques des convulsions fébriles. A propos de 325 cas à Yaoundé.

A prospective study of 325 children with febrile seizures was conducted in 2 hospitals in Yaoundé, from 15 January to 15 December 2008. The proportion of patients with febrile seizures among all admitted patients was 6.1%. The mean age was 24.6 months; the peak age of these patients was 12-17 months. The sex ratio was 1.5. The mean temperature on admission was 39.2 degrees C. There was a family history of febrile seizures in 36.4%. Simple febrile seizures were seen in 58.7% and the complex type in 41.3%. Malaria was the main etiology in 67.7%, followed by upper and lower respiratory tract infection in 14.1% and 9.8%, respectively. Lumbar puncture was performed in all patients. The commonest anticonvulsant used to stop seizures was rectal diazepam in 88%. Febrile seizure prophylaxis was administered to 43% of the patients; antipyretics were the most widely used, either alone or combined with rectal diazepam.

[Difficulties in the management of esophageal atresia in developing countries]. / Problematique de la prise en charge de l'atresie de l'œsophageen pays sous medicalises.

Oesophageal atresia is an extreme surgical emergency of the first week of birth. Authors report 10 cases treated in 5 years in two hospitals of Yaounde in Cameroon. This study high line: Difficulties of oesophageal atresia management in less medicalised countries. Possible solutions in this context.

Profil bacteriologique et de sensibilite aux antibiothiques dans les septicemies neonatales a l'hopital gyneco-obsetetrique et pediatrique de Yaounde

Les septicemies neonatales representaient 25des causes de mortalite neonatalite au Cameroun en 2004 .Ce travail a pour but de decrier le profile bacteriologique des septicemies neonatales ainsi que la sensibilite des germes cultives aux antibiotiques usuels. Soixante hemocultures ont pousse chez des nouveau-nes ages de 0 a 28 jours .Les germes retrouves se repartissent comme suite 39 enterobacteries (65); 12 staphylocoques (20) et 9 streptocoques (15).Au sein des enterobacteries; klebsiella pneumonie represente 27; Enterobacter cloacae 20; et Escherichia coli 13.Soixante sept pour cent des staphylocoques trouvent sont presentes chez les nouveau- nes age au moins de 7 jours. Concernant la sensibilite de ces germes aux antibiotiques jusque la utilises dans notre hopital ; nous avons constate une forte resistance des enterobacteries aux cephalosporines de troisieme generation; atteignent 77pour les cefotaximes et la ceftazadime. Ces enterobacteries restent sensibles a l'imipeneme dans 61des cas Les steaoptocoques sont sensibles a l'ampicilline et a la ceftriaxone dans 67des cas et la gentamicine est active sur 58des souches de staphylocoques. Ces resultats suggerent que l'antibiotherapie de premiere intention jusque la utilisee et comportant l'association de l'ampicilline avec une cephalosporine de troisieme generation et un aminoside ne presente plus une efficacite optimale .Cependant ; en raison du cout eleve de l'imipeneme dans notre contexte ; cette molecule pourrait etre reservee en premiere intention aux infections neonatales severes

Problematique de la prise en charge de l'atresie de l'oesophage en pays sous medicalises

L'atresie de l'oesophage est une extreme urgence chirurgicale de la 1ere semaine de vie. Les auteurs en rapportent 10 cas colliges et traites en 5 ans dans deux hopitaux de la ville de Yaounde au Cameroun. Cette etude met en relief : - les difficultes de la prise en charge de l'Atresie de l'oesophage en pays sous medicalises - les solutions possibles dans ce contexte

Anthropometric measurements of children attending a vaccination clinic in Yaounde, Cameroon.

BACKGROUND: Growth faltering is a frequent public health problem in children and anthropometric measurements are useful tools for follow-up and early diagnosis. This problem has not been studied in the Cameroonian setting, that's why we undertook this study. OBJECTIVES: To have a synopsis of the nutritional status in apparently healthy children attending a vaccination clinic and show the importance of anthropometric measurements in routine child health care. DESIGN: A retrospective study. PATIENTS AND PARTICIPANTS: 1351 children aged (6-24 months), who attended the vaccination clinic of the Yaounde Gynaeco-Obstetric and Pediatric Hospital over a 6 month period, were enrolled in the study. METHOD: The registers of the vaccination clinic of the above hospital were retrospectively reviewed from 1st March to 31st August 2005. The following parameters were noted: age, height, weight, mid-upper arm circumference (MUAC), and Z scores calculated for the following indicators: weight for age (WAZ), weight for height (WHZ), and height for age (HAZ). RESULTS: Our results show that 12 children (1.1 percent) in the 0-6 months age group and 4 (1.6 percent) in the 6-12 months age group had WAZ less than -2 indicating underweight. Also 10 children (0.9 percent) and 2 (0.8 percent) in the 0-6 and 6-12 months age groups respectively had WHZ less than -2, indicating wasting. HAZ was less than -2 in 70 children (6.4 percent) and in 8 (3.2 percent) in the 0-6 and 6-12 months age groups respectively indicating stunting. The MUAC was less than 12.5 cm in 6 children (2.4 percent). CONCLUSIONS: From our results, we conclude that growth faltering is common in supposedly healthy children attending our vaccination clinic. Anthropometric measurements are thus recommended and should be encouraged in routine child care settings for early diagnosis of growth retardation and to provide useful interventions.

Isolated congenital fusion of the gums.

Isolated congenital fusion of the gums is a rare anomaly. Early surgical treatment is indicated, as longstanding cases will impair normal feeding leading to nutritional and growth problems. We report the first case in the Yaoundé Gynaeco-Obstetric and Paediatric Hospital, which was successfully managed surgically.

The clinical spectrum of severe malaria in children in the east provincial hospital of Bertoua, Cameroon.

Severe malaria claims 1.5 to 2.7 million lives annually most of which are young children in rural areas in sub-Saharan Africa. We retrospectively reviewed the files of 387 patients, admitted and treated for severe malaria according to WHO guidelines, in the Bertoua provincial hospital, a peripheral health center in East Cameroon from 1st October 1998 to 30h October 2000. Our main objective was to study the epidemiological aspects, clinical presentation and outcome. The mean age was 2.7 years (range 2 months - 15 years) among them 214 males and 173 females giving a sex ratio of 1.2. Transmission was observed all year round at variable frequencies with peaks in the rainy seasons. Major symptoms were fever in 202 patients (52.2%), convulsions in 150 (38.8%), prostration in 79 (20.4%) and persistent vomiting in 78 patients (20.2%). Major clinical findings were severe pallor in 196 patients (50.6%) and splenomegaly in 75 patients (19.4%). The average time between onset of symptoms and consultation was 4.4 days (range 1 - 21 days). Blood smears were positive for Plasmodium falciparum in 288 patients (74.4%) and negative in 99 (25.6%). Concerning outcome, recovery was observed in 317 patients (81.9%), interruption of treatment (because of financial constraints) in 58 (15%) and 12 deaths (3.8%). Among the 317 patients who recovered, neurological sequelae were observed in six patients, blindness in four patients and deafness in three patients were the most frequent. We conclude that severe malaria constitutes a major challenge of early diagnosis together with implementation of appropriate treatment especially in rural areas. The use of WHO guidelines in the management of this disease and the recommended preventive measures of vector control have yielded good results in patients managed and followed up in our hospital.