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Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model.

Li, Kai; Yamamoto, Mie; Chan, Su Jing; Chiam, Mun Yee; Qin, Wei; Wong, Peter Tsun Hon; Yim, Evelyn King Fai; Tang, Ben Zhong; Liu, Bin.

Chem Commun (Camb) ; 50(96): 15136-9, 2014 Dec 14.

Article in English | MEDLINE | ID: mdl-25267167

ABSTRACT

Organic nanoparticles (NPs) with aggregation-induced emission (AIE) have been successfully used for tracking bone marrow stromal cells (BMSCs) in rats with ischemic stroke, highlighting the great potential of such fluorescent NPs in understanding the fate of transplanted stem cells for cell-based therapies.

Subject(s)

Cell Tracking , Mesenchymal Stem Cells/metabolism , Nanoparticles/metabolism , Organic Chemicals/chemistry , Animals , Bone Marrow Cells/cytology , Brain/pathology , Cells, Cultured , Disease Models, Animal , Fluorescent Dyes/chemistry , Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells/cytology , Microscopy, Fluorescence , Nanoparticles/chemistry , Pyrans/chemistry , Rats , Stroke/metabolism , Stroke/pathology , Stroke/therapy

ABSTRACT

Subject(s)

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