1.
Chem Commun (Camb)
; (14): 1860-2, 2005 Apr 14.
Article
in English
| MEDLINE
| ID: mdl-15795767
ABSTRACT
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin is described; the analogue and an advanced intermediate revealed microtubule stabilising properties in the micromolar range.
Subject(s)
Diterpenes/chemistry , Crystallography, X-Ray , Diterpenes/chemical synthesis , Epoxy Compounds/chemistry , Models, Molecular , Molecular Structure
2.
Org Lett
; 6(18): 3079-82, 2004 Sep 02.
Article
in English
| MEDLINE
| ID: mdl-15330592
ABSTRACT
[reaction: see text] Immobilization of copper onto modified Wang resin provided a polymer-supported copper catalyst, which is effective in cross-coupling reactions between N- or O-containing substrates and arylboronic acids. The copper catalyst is air stable and can be recycled with minimal loss of activity.