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1.
Dis Aquat Organ ; 146: 75-79, 2021 Oct 07.
Article in English | MEDLINE | ID: mdl-34617513

ABSTRACT

Lambl's excrescences (LE) are fibrous strands typically occurring at coaptation lines of cardiac valves. Although they have been widely reported in human medicine, information on LE occurrence in veterinary medicine is still scarce. The present study aimed to investigate the presence of LE in different freshwater fish and in swordfish. A total of 185 hearts were collected from different fish species, and samples of different cardiac areas (sinus venosus, atrial wall with sinoatrial valves, ventricular wall with atrioventricular valves and bulb with bulboventricular valves) were submitted to histopathological evaluation. LE were detected in 6 of 103 freshwater fish (5.8%) and 19 of 82 swordfish (23.2%). LE developed in atrioventricular, sinoatrial and bulboventricular valves. All affected valves also showed endocardiosis. Based on the results of the present work, teleost fish, specifically swordfish, could be proposed as a novel spontaneous model for the study of LE pathogenesis.


Subject(s)
Disease Models, Animal , Heart Valve Diseases , Animals , Fishes
2.
Anat Histol Embryol ; 48(3): 201-206, 2019 May.
Article in English | MEDLINE | ID: mdl-30772944

ABSTRACT

Anitschkow cells (AC) are a peculiar type of stromal cells observed in myocardium, cardiac valves and coronary vessels wall whose origin, characterization and role remain controversial. In human heart, they represent a histological hallmark of Aschoff nodules in rheumatic fever, but they have also been observed in other myocardial pathologies. Firstly, they have been considered a myocyte-derived cells, but light microscopy, immunohistochemical and ultrastructural studies pointed out that a macrophagic/histiocytic origin cannot be excluded. Many authors also reported extracardiac AC or an Anitschkow nuclear pattern, thus suggesting that these cells may represent a chromatin pattern rather than a specific cell type. In veterinary medicine, AC were described in myocarditis, myocardial necrosis, degenerative and inflammatory endocardial diseases of several species. Recently, AC have been observed in intramural coronary arteries of different animals (including cattle and fish) affected by arteriosclerotic processes. Stress related to the intensive livestock farming could represent a mechanotransduction promoting factor of arteriosclerotic changes allowing the development of Anitschkow chromatin pattern. Further studies both in human and veterinary medicine are needed to confirm the origin and role of these peculiar cells.


Subject(s)
Cardiovascular Diseases/pathology , Coronary Vessels/pathology , Heart Valves/pathology , Myocardium/pathology , Stromal Cells/pathology , Animals , Arteriosclerosis/pathology , Arteriosclerosis/veterinary , Humans , Livestock , Rheumatic Fever/pathology , Rheumatic Nodule/pathology
3.
J Vet Diagn Invest ; 24(3): 618-20, 2012 May.
Article in English | MEDLINE | ID: mdl-22529138

ABSTRACT

During the years 2009-2011, 7 Siberian tigers (Panthera tigris altaica), aged between 2 and 14 years, from the Safaripark of Pombia were referred for necropsy to the Department of Animal Pathology of the University of Turin (Italy). Three tigers, aged 10 (2 animals) and 14 years, had multifocal, irregularly distributed, white, soft, subpleural, 3-mm nodules scattered throughout the lungs. Histologically, there was a marked infiltration of macrophages, with foamy cytoplasm, and multinucleate giant cells interspersed with numerous clusters of cholesterol clefts. A mild lymphocytic infiltration was localized around the lesion. The findings were consistent with endogenous lipid pneumonia, which was considered an incidental finding of no clinical significance.


Subject(s)
Animals, Zoo , Cholesterol/metabolism , Pneumonia, Lipid/veterinary , Tigers , Animals , Cholesterol/analysis , Histocytochemistry/veterinary , Pneumonia, Lipid/metabolism , Pneumonia, Lipid/pathology
4.
J Zoo Wildl Med ; 43(4): 931-3, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23272365

ABSTRACT

A 2-yr-old male Siberian Tiger (Panthera tigris altaica) died during a fight with a conspecific. At necropsy, significant abnormalities included severe cardiomegaly with cardiac malformations consisting of a large atrial septal defect, a membranous ventricular septal defect, overriding aorta, and stenosis of the pulmonary valve with secondary concentric hypertrophy of the right ventricle. Endocardiosis of the mitral valve was also noted. To the authors' knowledge, this is the first report of a pentalogy of Fallot in a large felid that resulted in sudden death.


Subject(s)
Death, Sudden/veterinary , Heart Defects, Congenital/veterinary , Tigers , Animals , Animals, Zoo , Heart Defects, Congenital/pathology , Male
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