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Bioorg Med Chem Lett ; 9(8): 1109-12, 1999 Apr 19.
Article in English | MEDLINE | ID: mdl-10328294

ABSTRACT

A selective potent anti-Helicobacter pylori isoflavone was isolated from a Brazilian Medicinal Plant, Myroxylon peruiferum. The isolation bioassay-guided and the characterization of an active anti-H. pylori constituent was performed using the methanol extract of plant of minute amount. The active compound was identified as cabreuvin (1), an isoflavone derivative. The structure-activity relationships of several related compounds were also investigated.


Subject(s)
Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Helicobacter pylori/drug effects , Isoflavones/analysis , Plants, Medicinal/chemistry , Isoflavones/pharmacology , Structure-Activity Relationship
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