ABSTRACT
Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group.
Subject(s)
Plasminogen/isolation & purification , Prostatic Neoplasms/blood , Aged , Humans , Male , Middle Aged , Plasminogen/analysis , Protein Isoforms/bloodABSTRACT
We examined 408 patients operated for prostatic adenoma and estimated frequency of detection of incidental prostatic cancer (PC), determined PC clinical and pathological characteristics in patients exposed to preoperative prostatic biopsy and patients with no indications for such biopsy. The most significant factor in prognosis of the risk of cancer detection for patients exposed to biopsy is evidence obtained at finger rectal examination, transrectal ultrasound investigation, age; for patients unexposed to biopsy - PSA level is significant.
