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1.
Bull Exp Biol Med ; 168(1): 18-23, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31741240

ABSTRACT

We studied the structure of rhythms of BP, HR (by telemetric monitoring), electrolyte excretion (by capillary electrophoresis), and products of epiphyseal melatonin (by the urinary concentration of 6-sulfatoxymelatonin measured by ELISA) in normotensive Wistar-Kyoto rats and spontaneously hypertensive SHR rats maintained at 16/8 h and 20/4 h light-dark regimes. In Wister-Kyoto rats exposed to prolonged daylight, we observed changes in the amplitude, rhythm power (% of rhythm), and range of oscillations of systolic BP; HR mezor decreased. In SHR rats, mezor of HR also decreased, but other parameters of rhythms remained unchanged. Changes in electrolyte excretion were opposite in normo- and hypertensive rats. Under conditions of 20/4 h light-dark regime, daytime melatonin production tended to increase in normotensive rats and significantly increased in SHR rats. At the same time, nighttime melatonin production did not change in both normotensive and hypertensive animals. As the secretion of melatonin has similar features in animals of both lines, we can say that the epiphyseal component of the "biological clock" is not the only component of the functional system that determines the response of the studied rhythms to an increase in the duration of light exposure.


Subject(s)
Blood Pressure/physiology , Circadian Rhythm/physiology , Melatonin/metabolism , Animals , Electrolytes , Enzyme-Linked Immunosorbent Assay , Heart Rate/physiology , Hypertension/metabolism , Hypertension/physiopathology , Rats , Rats, Inbred WKY
2.
Int J Biometeorol ; 61(5): 921-929, 2017 May.
Article in English | MEDLINE | ID: mdl-27878388

ABSTRACT

There are many references in the literature related to connection between the space weather and the state of human organism. The search of external factors influence on humans is a multi-factor problem and it is well known that humans have a meteo-sensitivity. A direct problem of finding the earth weather conditions, under which the space weather manifests itself most strongly, is discussed in the present work for the first time in the helio-biology. From a formal point of view, this problem requires identification of subset (magnetobiotropic region) in three-dimensional earth's weather parameters such as pressure, temperature, and humidity, corresponding to the days when the human body is the most sensitive to changes in the geomagnetic field variations and when it reacts by statistically significant increase (or decrease) of a particular physiological parameter. This formulation defines the optimization of the problem, and the solution of the latter is not possible without the involvement of powerful metaheuristic methods of searching. Using the algorithm of differential evolution, we prove the existence of magnetobiotropic regions in the earth's weather parameters, which exhibit magneto-sensitivity of systolic, diastolic blood pressure, and heart rate of healthy young subjects for three weather areas (combinations of atmospheric temperature, pressure, and humidity). The maximum value of the correlation confidence for the measurements attributable to the days of the weather conditions that fall into each of three magnetobiotropic areas is an order of 0.006, that is almost 10 times less than the confidence, equal to 0.05, accepted in many helio-biological researches.


Subject(s)
Blood Pressure , Geological Phenomena , Heart Rate , Magnetic Phenomena , Weather , Adult , Earth, Planet , Female , Healthy Volunteers , Humans , Male , Young Adult
3.
Bull Exp Biol Med ; 159(2): 269-72, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26085362

ABSTRACT

The results of long-term (1998-2012) biomedical monitoring of the biotropic effects of space weather are discussed. A drastic change in statistical distribution parameters in the middle of 2005 was revealed that did not conform to usual sinusoidal distribution of the biomedical data reflecting changes in the number of solar spots over a solar activity cycle. The dynamics of space weather of 2001-2012 is analyzed. The authors hypothesize that the actual change in statistical distributions corresponds to the adaptation reaction of the biosphere to nonstandard geophysical characteristics of the 24th solar activity cycle and the probable long-term decrease in solar activity up to 2067.


Subject(s)
Aerospace Medicine/methods , Biota/radiation effects , DNA, Fungal/radiation effects , Galvanic Skin Response/radiation effects , Solar Activity , Aerospace Medicine/history , Galvanic Skin Response/physiology , History, 21st Century , Humans , Longitudinal Studies , Saccharomyces cerevisiae , Staining and Labeling , Time Factors
4.
Klin Med (Mosk) ; 92(8): 36-40, 2014.
Article in Russian | MEDLINE | ID: mdl-25790695

ABSTRACT

Disturbances in coordination between physiological functions of the cardiovascular system develop in healthy people as a result ofdisordered sleep-wake cycle especially associated with psycho-emotional stress. A classical example is desynchronosis in locomotive drivers. Similar condition develops in association with severe somatic pathology e.g. in oncological patients. The study was designed to analyse peculiarities of desynchronosis associated with shift-based jobs and in the patients with oncological diseases. The control group was comprised of the students and teachers of the University of People's Friendship. Diagnostics and evaluation of desynchronosis severity were performed by complex correlation-regressive analysis and pre-trip AP and HR measurements in locomotive drivers. In healthy subjects, all regression coefficients were positive and significant in combination with middle-strength correlation coefficients which ensured maximum coordination in the work of the coupled systems without the loss of plasticity between physiological contours. Patients with severe somatic pathology showed multidirectional functioning of physiological contours (stable dyscoordination) with the enhanced relationship between the parameters of interest and with manifestations of "rigidity". Multidirectional functioning of coupled systems was equally characteristic of locomotive drivers, but the relationship between the parameters being studied was less expressed and attributable to an adaptive reaction because the relationship recovered during the rest periods between shifts.


Subject(s)
Adaptation, Physiological/physiology , Chronobiology Disorders/physiopathology , Neoplasms/complications , Occupational Diseases/physiopathology , Work Schedule Tolerance/physiology , Adult , Chronobiology Disorders/etiology , Humans , Occupational Diseases/etiology
5.
Klin Med (Mosk) ; 90(9): 57-9, 2012.
Article in Russian | MEDLINE | ID: mdl-23214017

ABSTRACT

Antiarrhythmic therapy of patients with disturbed automatism of the sinus node and impaired atrioventricular conductance may be complicated by hemodynamically significant bradycardias and contraindications for implantation of a cardiac electrical stimulator This study aimed at estimating effect of antiarrhythmic therapy with allapinin on the function of sinus and atrioventricular nodes. It included 20 patients (mean age 37.5+-2.3 years) with disturbed cardiac rhythm and sinus node dysfunction treated with allapinin (37.5 - 50 mg/d per os). This therapy had well apparent antiarrhythmic effect manifest as improvement of supraventricular and ventricular ectopic activities in the absence of negative influence on the function of sinus and atrioventricular nodes.


Subject(s)
Aconitine/analogs & derivatives , Heart Conduction System/drug effects , Sick Sinus Syndrome/complications , Tachycardia, Paroxysmal , Ventricular Premature Complexes , Aconitine/administration & dosage , Aconitine/adverse effects , Adult , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/adverse effects , Bradycardia/chemically induced , Depression, Chemical , Dose-Response Relationship, Drug , Drug Monitoring , Electrocardiography, Ambulatory , Electrophysiologic Techniques, Cardiac , Female , Heart Conduction System/physiopathology , Heart Rate/drug effects , Humans , Male , Sick Sinus Syndrome/diagnosis , Sick Sinus Syndrome/physiopathology , Tachycardia, Paroxysmal/diagnosis , Tachycardia, Paroxysmal/drug therapy , Tachycardia, Paroxysmal/etiology , Tachycardia, Paroxysmal/physiopathology , Treatment Outcome , Ventricular Premature Complexes/diagnosis , Ventricular Premature Complexes/drug therapy , Ventricular Premature Complexes/etiology , Ventricular Premature Complexes/physiopathology
6.
Klin Med (Mosk) ; 89(3): 50-3, 2011.
Article in Russian | MEDLINE | ID: mdl-21861405

ABSTRACT

We studied effect of the neoplastic process and surgical treatment on parameters of the oxidative system in patients with stomach cancer including serum and gastric tissue levels of malonic dialdehyde, lactic and pyruvic acids in stage I-IV malignancy before and after radical surgery. The development and generalization of the neoplastic process are associated with the activation of oxidative reactions leading to endotoxicosis. Specific anticarcinogenic treatments (including surgery) aggravate changes in the oxidative systems and further deteriorate quality of life and tolerance of the treatment.


Subject(s)
Lactic Acid/metabolism , Malondialdehyde/metabolism , Oxidative Stress/physiology , Pyruvic Acid/metabolism , Stomach Neoplasms/metabolism , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neoplasm Staging , Prognosis , Retrospective Studies , Severity of Illness Index , Stomach Neoplasms/pathology
7.
Klin Med (Mosk) ; 89(1): 44-8, 2011.
Article in Russian | MEDLINE | ID: mdl-21516766

ABSTRACT

The study was designed to assess clinical efficiency and safety of nebivolol in patients with cardiovascular problems and chronic obstructive pulmonary disease. It included 50 patients of whom 25 were given daily 5 and 25 mg of nebivolol and 80-100 mg of verapamil. Nebivolol was shown to significantly reduce arterial pressure, heart rate, and the number of ventricular extrasystoles. The drug was well tolerated by the patients and had no adverse effect on bronchial patiency.


Subject(s)
Benzopyrans/therapeutic use , Coronary Disease/drug therapy , Ethanolamines/therapeutic use , Pulmonary Disease, Chronic Obstructive/drug therapy , Adrenergic beta-1 Receptor Antagonists/therapeutic use , Adult , Aged , Coronary Disease/complications , Coronary Disease/diagnosis , Disease Progression , Echocardiography , Electrocardiography , Follow-Up Studies , Humans , Middle Aged , Nebivolol , Nitric Oxide/metabolism , Pulmonary Disease, Chronic Obstructive/complications , Pulmonary Disease, Chronic Obstructive/metabolism , Respiratory Function Tests , Treatment Outcome
8.
Klin Med (Mosk) ; 88(2): 41-2, 2010.
Article in Russian | MEDLINE | ID: mdl-21105470

ABSTRACT

This study showed that monitoring arterial pressure and heart rate during a few consecutive days allows for early diagnosis of cardiovascular disorders long before manifestation of its clinical symptoms. It is maintained that atrial fibrillation and fluttering are preceded by systemic disturbances of systolic pressure regulation.


Subject(s)
Adaptation, Physiological , Atrial Fibrillation/physiopathology , Blood Pressure , Heart Rate , Atrial Fibrillation/diagnosis , Atrial Fibrillation/therapy , Circadian Rhythm , Early Diagnosis , Electric Countershock , Electrocardiography, Ambulatory , Hemodynamics , Humans , Male
9.
Bull Exp Biol Med ; 149(4): 490-6, 2010 Oct.
Article in English, Russian | MEDLINE | ID: mdl-21234450

ABSTRACT

The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force and parametric noise, a new dynamic model is proposed, which incorporates two control physical parameters: power of signal generation and coefficient of diffuse signal scattering. For the entire set of parameters, the examined modeled nonlinear system demonstrated a number of various performance modes ranging from steady-state periodic and quasi-periodic states to chaos. The model showed that variations in cosmic, geophysical, and weather conditions in the frequency range of 0.1-0.9 Hz produce the greatest biotropic influence.


Subject(s)
Heart/physiology , Models, Cardiovascular , Computer Simulation , Electrocardiography , Humans , Nonlinear Dynamics , Periodicity
11.
Klin Med (Mosk) ; 87(3): 35-8, 2009.
Article in Russian | MEDLINE | ID: mdl-19469253

ABSTRACT

The aim of the study was to examine effect of cardioversion (CV) on the subjective and objective status of patients with persistent atrial fibrillation (AF) receiving different therapy. The study included 4 groups of patients (n = 85). Group 1 (n = 30) were given standard treatment. In group 2 (n = 25), standard therapy was supplemented by i.v. injections of emoxipin (200 mg/day). Treatment of group 3 (n = 10) included mildronat (50 mg/day, i.v.), patients of group 4 (n = 20) were given riboxin (200 mg/day, i.v.). It was shown that the recovery of sinus rhythm improved the quality of life and parameters of cardiovascular function in all the treated patients.


Subject(s)
Atrial Fibrillation/psychology , Electric Countershock/methods , Quality of Life , Atrial Fibrillation/physiopathology , Atrial Fibrillation/therapy , Cardiovascular Agents/administration & dosage , Cardiovascular Agents/therapeutic use , Echocardiography, Doppler , Electrocardiography, Ambulatory , Female , Follow-Up Studies , Heart Rate/physiology , Humans , Injections, Intravenous , Inosine Diphosphate/administration & dosage , Inosine Diphosphate/therapeutic use , Male , Methylhydrazines/administration & dosage , Methylhydrazines/therapeutic use , Middle Aged , Stroke Volume/physiology , Treatment Outcome
12.
Klin Med (Mosk) ; 87(3): 68-70, 2009.
Article in Russian | MEDLINE | ID: mdl-19469262

ABSTRACT

Patient N presented with a well-apparent abnormality of chronological structure of heart beat biorhythms despite the absence of subjective complaints throughout the six-month long observation period. It was shown that AP peaks were associated with a significant decrease of circadian index (CI), i.e. the development of a rigid daily heart contraction rhythm. The reduction of CI as a specific indicator of stability of the daily cardiac contraction rhythm gave evidence of altered vegetative regulation of cardiac function during hypertension. Rigidity of the daily heart contraction rhythm increased with increasing severity of the disease. Smoothing of the circadian rhythm profile suggests depletion of adaptive reserve and the development of the "denervated" heart phenomenon. Cardioversion created a tendency towards normalization of circadian index.


Subject(s)
Atrial Fibrillation/physiopathology , Blood Pressure Monitoring, Ambulatory/methods , Blood Pressure/physiology , Circadian Rhythm/physiology , Electrocardiography, Ambulatory/methods , Heart Rate/physiology , Tachycardia, Paroxysmal/physiopathology , Atrial Fibrillation/therapy , Electric Countershock , Follow-Up Studies , Humans , Male , Middle Aged , Tachycardia, Paroxysmal/therapy , Time Factors
13.
Bull Exp Biol Med ; 145(6): 765-8, 2008 Jun.
Article in English | MEDLINE | ID: mdl-19110572

ABSTRACT

This paper presents the results of 9-year biogeophysical monitoring (1998-2007) of spatial and time effects of space weather and atmospheric and climatic factors on the status of normal subjects, which was carried out simultaneously in geographical areas situated at different latitudes. Requirements to conditions of long-term telecommunication biogeophysical monitoring studies are formulated, providing the reliability and reproducibility of the experiment results. The results indicate that the role of atmospheric and climatic factors in modification of dynamic regimens of human body functioning is significantly higher in subjects living at lower latitudes. The spatial and time regularities of the effects of space and physical factors on human body were detected (the latitude, time, trigger, amplitude, synergetic, and cumulative effects of the population averaging of the reaction). These effects indicate that human body belongs to a class of open nonlinear dynamic systems with all characteristics intrinsic of it.


Subject(s)
Cardiovascular Physiological Phenomena , Monitoring, Physiologic/methods , Telecommunications , Climate , Geography , Humans , Monitoring, Physiologic/instrumentation , Reproducibility of Results
15.
Klin Med (Mosk) ; 86(6): 30-5, 2008.
Article in Russian | MEDLINE | ID: mdl-18720708

ABSTRACT

Metabolic syndrome has a close association with "diseases of civilization" and widespread in economically developed countries. By the end of XX century, unification in clusters of cardiovascular diseases risk factors showed, that simultaneous presence of obesity, type 2 diabetes mellitus, arterial hypertension, insulin resistance, hyperinsulinemia and hyperlipidemia contributed to significant increase in mortality.


Subject(s)
Metabolic Syndrome , Diagnosis, Differential , Humans , Hyperinsulinism/complications , Hyperinsulinism/epidemiology , Hypertension/complications , Hypertension/epidemiology , Insulin Resistance , Metabolic Syndrome/diagnosis , Metabolic Syndrome/epidemiology , Metabolic Syndrome/etiology , Morbidity/trends , Obesity/complications , Obesity/epidemiology , Risk Factors , Russia/epidemiology
16.
Bull Exp Biol Med ; 145(5): 579-83, 2008 May.
Article in English | MEDLINE | ID: mdl-19145286

ABSTRACT

Acute coronary failure was modeled in rabbits by ligation of the descending left coronary artery at the interface of its middle and lower thirds. The function and morphology of left-ventricular and right-ventricular myocardium were studied on days 1, 3, and 5 of the pathological process. It was found that left-ventricular contractility decreased, while right-ventricular contractility increased. Deep morphological changes were observed in both ventricles: pronounced extracellular edema, increased content of collagen, decreased percentage of myofibrils. Hence, acute coronary failure involves both compartments of the heart, but the adaptive mechanisms more actively develop in the right ventricle.


Subject(s)
Acute Coronary Syndrome/pathology , Acute Coronary Syndrome/physiopathology , Adaptation, Physiological , Animals , Apoptosis , Collagen/metabolism , Edema/pathology , Male , Myocardial Contraction , Myocytes, Cardiac/pathology , Myofibrils/pathology , Rabbits , Ventricular Dysfunction, Left/pathology , Ventricular Dysfunction, Left/physiopathology , Ventricular Dysfunction, Right/pathology , Ventricular Dysfunction, Right/physiopathology
18.
Klin Med (Mosk) ; 85(12): 22-6, 2007.
Article in Russian | MEDLINE | ID: mdl-18318161

ABSTRACT

Forty-five patients with coronary heart disease and various forms of ventricular arrhythmias (25 men and 20 women aged 42 to 73) were examined. The use of complex therapy with emoxipin and preductal in a combination with antiarrhythmic agents potentated the action of these preparations. The application of emoxipin resulted in a longer positive effect.


Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Picolines/therapeutic use , Tachycardia, Ventricular/drug therapy , Trimetazidine/therapeutic use , Vasodilator Agents/therapeutic use , Adult , Aged , Drug Therapy, Combination , Electrocardiography , Female , Follow-Up Studies , Heart Rate/drug effects , Humans , Male , Middle Aged , Tachycardia, Ventricular/physiopathology , Treatment Outcome
19.
Biomed Pharmacother ; 59 Suppl 1: S239-61, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16275502

ABSTRACT

We analyzed cycles with periods, tau, in the range of 0.8-2.0 years, characterizing, mostly during 1999-2003, the incidence of sudden cardiac death (SCD), according to the International Classification of Diseases, 10th revision (ICD10), code I46.1. In the tau range examined, only yearly components could be documented in time series from North Carolina, USA; Tbilisi, Georgia; and Hong Kong, in the latter two locations based on relatively short time series. By contrast, in Minnesota, USA, we found only a component with a longer than (= trans) yearly (transyearly) tau of 1.39 years; the 95% confidence interval (CI) of the tau extended from 1.17 to 1.61 years, falling into the category of transyears (defined as a tau and a 95% CI between 1.0 and 2.0 years, with the limits of the 95% CI of the spectral component's tau overlapping neither of these lengths). During the same span from 1999 to 2003 in Arkansas, USA, a component of about 1-year in length was present, and in addition, one with a tau of 1.69 year with a CI extending from 1.29 to 2.07 years, a far-transyear candidate, far-transyears being defined as having a tau with a CI between 1.20 and 2.0 year, with the CI overlapping neither of these lengths. In the Czech Republic, there was also a calendar-yearly tau and one of 1.76 years. In the latter two geographic/geomagnetic areas, the about-yearly and the longer cycles' amplitudes were of similar prominence. The taus are only candidate transyears; the 95% CIs of their taus overlap the 2-year length. When a series on SCD from 1994 to 2003 from the Czech Republic was analyzed, the 95% CI of the transyear's tau no longer overlapped the 2-year length. Transyears were also found in the Czech Republic for myocardial infarctions (MI), meeting the original transyear definition in both a shorter and a longer series. Moreover, in the 1994-2003 series on MI from the Czech Republic, a near-transyear was also found, meeting the definition of a period with a 95% CI overlapping neither precisely 1.0 year nor 1.2 years, along with a far-transyear, defined as a tau between 1.2 and 2.0 years, again with the 95% CI covering neither of these lengths. Herein, we discuss near- and far-transyears more generally in the light of their background in physics and the concept of reciprocal cyclicities.


Subject(s)
Chronobiology Phenomena , Death, Sudden, Cardiac/epidemiology , Myocardial Infarction/epidemiology , Solar Activity , Czech Republic/epidemiology , Geography , Georgia (Republic)/epidemiology , Hong Kong/epidemiology , Humans , United States/epidemiology
20.
Biomed Pharmacother ; 59 Suppl 1: S24-30, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16275503

ABSTRACT

A multi-center four-hourly sampling of many tissues for 7 days (00:00 on April 5-20:00 to April 11, 2004), on rats standardized for 1 month in two rooms on antiphasic lighting regimens happened to start on the day after the second extremum of a moderate double magnetic storm gauged by the planetary geomagnetic Kp index (which at each extremum reached 6.3 international [arbitrary] units) and by an equatorial index Dst falling to -112 and -81 nT, respectively, the latter on the first day of the sampling. Neuroendocrine chronomes (specifically circadian time structures) differed during magnetically affected and quiet days. The circadian melatonin rhythm had a lower MESOR and lower circadian amplitude and tended to advance in acrophase, while the MESOR and amplitude of the hypothalamic circadian melatonin rhythm were higher during the days with the storm. The circadian parameters of circulating corticosterone were more labile during the days including the storm than during the last three quiet days. Feedsidewards within the pineal-hypothalamic-adrenocortical network constitute a mechanism underlying physiological and probably also pathological associations of the brain and heart with magnetic storms. Investigators in many fields can gain from at least recording calendar dates in any publication so that freely available information on geomagnetic, solar and other physical environmental activity can be looked up. In planning studies and before starting, one may gain from consulting forecasts and the highly reliable nowcasts, respectively.


Subject(s)
Chronobiology Phenomena , Electromagnetic Fields , Neurosecretory Systems/physiology , Solar Activity , Animals , Circadian Rhythm , Feedback , Hypothalamus/metabolism , Lighting , Melatonin/metabolism , Pineal Gland/metabolism , Rats , Rats, Wistar
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