ABSTRACT
Two preterm infants with athetoid cerebral palsy due to bilirubin encephalopathy were examined by magnetic resonance spectroscopic imaging at age 3 years. An increased glutamate/glutamine complex/creatine ratio was found in the basal ganglia. Chemical metabolic abnormalities of the basal ganglia were clearly demonstrated by color-coded metabolite images.
Subject(s)
Basal Ganglia/metabolism , Infant, Premature, Diseases/diagnosis , Kernicterus/diagnosis , Magnetic Resonance Spectroscopy , Protons , Female , Glutamates/metabolism , Glutamine/metabolism , Humans , Infant, Low Birth Weight/metabolism , Infant, Newborn , Infant, Premature/metabolism , Infant, Premature, Diseases/metabolism , Kernicterus/metabolism , Male , PregnancyABSTRACT
A 3-year-old boy with Kawasaki disease developed a cerebral infarction after high-dose intravenous immunoglobulin. Aspirin did not prevent the stroke. Based on the numerous reports of thrombosis due to high-dose immunoglobulin in older individuals, we conclude that it is necessary to be aware of this complication when treating children with Kawasaki disease.
Subject(s)
Cerebral Infarction/chemically induced , Immunoglobulins, Intravenous/adverse effects , Mucocutaneous Lymph Node Syndrome/drug therapy , Child, Preschool , Dose-Response Relationship, Drug , Humans , Immunoglobulins, Intravenous/administration & dosage , MaleABSTRACT
Three Japanese patients with peroxisomal acyl coenzyme A oxidase deficiency who manifested psychomotor retardation and regression during the late infantile period showed characteristic patterns of demyelination in the ponto- medullary corticospinal tracts and in the cerebellar and cerebral white matter. Molecular investigations revealed 2 novel missense mutations, M278V and G178C.