ABSTRACT
In 13 patients, affected by hypertrophic obstructive cardiomyopathy (HOCM) and essential hypertension, antihypertensive-efficacy and effects of a new calcium-channel blocker (gallopamil) associated with a diuretic agent (chlorthalidone) on left ventricular systolic and diastolic performance assessed by phonocardiographic methods. The results were compared to those obtained, in the same group of patients, with a selective beta-blocker (atenolol) associated with the same diuretic agent (chlorthalidone). With both therapeutic regimens a statistically significant reduction of systolic and diastolic arterial pressure was observed; both agents were able to reduce hemodynamic gradient in systole which characterize HOCM; however, the treatment with gallopamil plus chlorthalidone determined greater effects on left ventricular diastolic function as compared to the treatment with atenolol plus chlorthalidone; both treatments determined bradycardia.
Subject(s)
Atenolol/therapeutic use , Cardiomyopathy, Hypertrophic/drug therapy , Chlorthalidone/therapeutic use , Gallopamil/therapeutic use , Adult , Aged , Cardiomyopathy, Hypertrophic/complications , Diastole/drug effects , Drug Evaluation , Drug Therapy, Combination , Female , Heart Ventricles , Humans , Hypertension/complications , Hypertension/drug therapy , Male , Middle Aged , Systole/drug effectsSubject(s)
Blood Pressure/drug effects , Glutamates/pharmacology , Heart Rate/drug effects , Kainic Acid/pharmacology , Sodium Glutamate/pharmacology , Animals , Dose-Response Relationship, Drug , Injections, Intraventricular , Kainic Acid/administration & dosage , Rats , Sodium Glutamate/administration & dosageSubject(s)
Adrenergic beta-Agonists/pharmacology , Ethanolamines/pharmacology , Adrenergic beta-Agonists/therapeutic use , Animals , Bronchi/drug effects , Bronchial Spasm/drug therapy , Cats , Dogs , Ethanolamines/therapeutic use , Female , Guinea Pigs , Male , Mice , Procaterol , Rabbits , Rats , Trachea/drug effectsABSTRACT
In dogs, treatment with guanabenz, carteolol, and muzolimine for 7 days, reduced the blood pressure responses to bilateral occlusion of the carotid arteries, electric stimulation of central vagus nerve, acetylcholine after atropinization, nicotine, l-noradrenaline, angiotensin II, l-adrenaline, KC1 and asphyxia.
Subject(s)
Blood Pressure/drug effects , Carteolol/pharmacology , Guanabenz/pharmacology , Guanidines/pharmacology , Muzolimine/pharmacology , Propanolamines/pharmacology , Pyrazoles/pharmacology , Anesthesia , Animals , Dogs , MaleABSTRACT
The synthesis of three series of glycinamides (IV), amides (V) and diamines (VI) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of compounds (IV), (V) and (VI) showed a moderate hypotensive activity in rats. Effects on heart rate in rats, infiltration anesthesia and antiarrhythmic activity in mice, as well as antiacetylcholine activity in vitro, are also reported.
Subject(s)
Antihypertensive Agents/chemical synthesis , Camphanes/chemical synthesis , Acetylcholine/antagonists & inhibitors , Anesthetics, Local , Animals , Anti-Arrhythmia Agents , Blood Pressure/drug effects , Camphanes/pharmacology , Chemical Phenomena , Chemistry , Epinephrine/antagonists & inhibitors , Heart Rate/drug effects , Mice , RatsSubject(s)
Coronary Circulation/drug effects , Myocardium/metabolism , Phosphocreatine/physiology , Animals , Dogs , MaleSubject(s)
Fatty Alcohols/pharmacology , Hypolipidemic Agents , Animals , Bile/drug effects , Bile/metabolism , Cholesterol/metabolism , Female , Hyperlipidemias/drug therapy , Male , Mice , Rabbits , RatsABSTRACT
In basis of our experimental researches bunitrolol presented: a) beta-adrenolytic activity prevailingly at cardiac level (superior to propranolol and practolol) in respect to vascular, tracheal, bronchial, uterus, intestinal and metabolic level; b) beta-adrenergic intrinsic activity; c) local anesthetic activity; d) chinidino-like activity; e) antiarrhythmic activity; f) hypotensive activity with interferences at the level of vasomotor centres, of the barosensitive zones, of the renin secretion and of the purinergic periphery.
Subject(s)
Cardiovascular System/drug effects , Propanolamines/pharmacology , Sympathetic Nervous System/drug effects , Animals , Anura , Blood Glucose/analysis , Blood Pressure/drug effects , Cats , Coronary Circulation/drug effects , Dogs , Drug Evaluation, Preclinical , Ethanolamines/pharmacology , Fatty Acids, Nonesterified/blood , Guinea Pigs , Heart Rate/drug effects , Lipid Metabolism , Muscle, Smooth/drug effects , Propranolol/pharmacology , Rabbits , Rats , Vasomotor System/drug effectsABSTRACT
In experiments at cardiovascular system level, acebutolol was found to possess beta-adrenolytic activity of cardioselective type associated with intrinsic beta-adrenergic, antiarrhythmic and anti-hypertensive activity. It was well tolerated systemically.
Subject(s)
Acebutolol/pharmacology , Cardiovascular System/drug effects , Adrenergic beta-Antagonists/pharmacology , Animals , Blood Glucose/analysis , Blood Pressure/drug effects , Cats , Coronary Circulation/drug effects , Dogs , Drug Evaluation, Preclinical , Fatty Acids, Nonesterified/blood , Female , Guinea Pigs , Heart Rate/drug effects , Intestines/drug effects , Male , Muscle, Smooth/drug effects , Practolol/pharmacology , Propranolol/pharmacology , Rabbits , Rats , Uterus/drug effectsABSTRACT
In vivo and in vitro experiments showed that Verapamil dilates the coronaries, prevents coronary spasm, produces Ca++-antagonism, offers protection against myocardial necrosis, prevents arrhythmia, reduces pressure, increases the purinergic reactivity and produces inhibition of platelet aggregation. It was devoid of competitive-adrenolytic activity in the heart and vessels. A methoxy derivative of the drug (D-600) had a negative inotropic and chronotropic action and was more hypotensive than Verapamil.
