[Cytological identification of the lymphocytes in highly leukemic AKR/J mice in ontogenesis. Effect of somatotropin on the cellular composition of the lymphoid organs]. / Tsitologicheskaia identifikatsiia limfotsitov u vysokoleikoznykh myshei linii AKR/J v ontogeneze. Vliianie somatotropnogo gormona na kletochnyi sostav limfoidnykh organov.

In AKR/J mice lymphocytes of thymus, spleen and lymph nodes can be classified according to their morphology as revealed by the Stockinger and Kellner staining: I--basophilic cytoplasm, 1--3 large basophilic nucleoli (blast cells), II--basophilic cytoplasm, 1--4 small clearly visible nucleoli (T-lymphocytes), III-weakly basophilic cytoplasm, 1-4 small fairly visible nucleoli (B-lymphocytes). The number of cells of types I and II increases with the progressing of leucaemia. After the administration of somatotrophic hormone the number of cells of types I and II increases only in the lymphoid organs of 5 months old AKR/J mice.

[Effect of somatotropic hormone on autoimmune responses induced in mice of different genotypes by syngenous heated erythrocytes]. / Vliianie somatotropnogo gormona na autoimmunye reaktsii, indutsirovannye u myshei raznykh genotipov singennymi progretymi éritrotsitami

A single administration of 1 X 10(9) heated erythrocytes to C57BL and BALB/c mice caused on the 13th day the appearance of antierythrocytic autoantibodies, an increase in the weight of the lymphoid organs, and lymphoreticular hyperplasia. These changes were more pronounced in BALB/c mice. During the development of autoimmune reactions the changes in the number of E- and EAC-rosette-forming cells in the thymus and spleen and in the immune response to the sheep erythrocyte immunization and E. coli endotoxin were revealed; distinct strain differences were observed. Daily somatotropic hormone administration (5 mg/kg of body weight) for 10 days decreased the degree of the autoimmune reactions development in mice of both strains. Its action was more expressed in BALB/c mice.