SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION DECREASES IN CORRELATION WITH GLYCATED HEMOGLOBIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES.

Our aim was to compare serum vascular endothelial growth factor (VEGF) level in type 2 diabetes mellitus (T2DM) patients with comorbid OSA at screening and 6 month follow up visits. In the prospective cohort study following data were collected at screening visit: medical anamnesis; demographic and anthropometric data; Epworth sleepiness score data; laboratory (serum VEGF, complete blood count, biochemistry, immunology, complete urine test, including microalbuminuria) and instrumental investigation data (fundoscophy, laboratory polysomnography). At 6 months follow up visit we evaluated anthropometric data; Epworth sleepiness score; serum VEGF. Comparing VEGF level at screening and 6 month follow up visits showed significant decrease in VEGF level in both groups (P=0.0281 OSA+ and P=0.0278 OSA-). It was established direct correlation between decreased VEGF level and decreased HbA1c level (P=0.04696) and between decreased VEGF level and Epworth sleepiness score (P=0.0153) at 6 month follow up visit in OSA+ group. Our the study suggests that VEGF level decreases in parallel with diabetes compensation quality. Future researches are necessary to support this research.

[Dynamics of the summary electrical activity of the dorsal hippocampus during development of experimental informational behavioral pathology]. / Dinamika summarnoi élektricheskoi aktivnosti dorzal'nogo gippokampa pri razvitii éksperimental'noi informatsionnoi patologii povedenii.

Dynamics of dorsal hippocampal EEG changes were traced in cats during the short-term memory loads under conditions of the time deficit between the separate delayed reactions. Shortening the intervals between the tests from 3-5 min to 15-20 s led to an expressed ECoG desynchronization accompanied by an initial increase and later blockade of the hippocampal theta-rhythm. Hippocampal theta-activity changes under conditions of the time deficit was a result of emotional stress. The long emotional stress impaired the short-term image memory, and this was manifested in hippocampal theta-rhythm disappearance.

[Effect of self-stimulation of the septum pellucidum on disrupted delayed reactions in cats]. / Vliianie samostimuliasii peregorodki mozga na narushennye otsrochennye reaktsii u koshek.

The effect of self-stimulation of the septum on impaired delayed reactions was studied on cats in a state of neurotization. Reduction of intervals between tests from 3-5 min to 30-40 s produced a complex of motor and vegetative reactions testifying to augmentation of emotional stress. This was followed by disturbance of short-term memory of complex perception of the location of food. Self-stimulation of the septum by animals in a state of experimental neurosis caused considerable improvement and then recovery of the maximum of delayed reactions This testifies to the important role of the septum in regulation of the level of emotional stress, and hence, a normal course of higher brain functions.