Subject(s)
Colonic Diseases/diagnostic imaging , Hernia, Abdominal/diagnostic imaging , Intestinal Obstruction/etiology , Barium Sulfate , Colonic Diseases/complications , Colonic Diseases/surgery , Female , Follow-Up Studies , Hernia, Abdominal/complications , Hernia, Abdominal/surgery , Humans , Intestinal Obstruction/diagnostic imaging , Intestinal Obstruction/surgery , Laparotomy/methods , Lumbosacral Region , Middle Aged , Rare Diseases , Risk Assessment , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
The significance and effectiveness of adjuvant intraoperative chemotherapy using subserosal or submucosal administration of Neocarzinostatin (NCS) and CH 40 for gastric cancer and colorectal cancer were studied. Tissue NCS concentration of proximal lymph nodes were higher than for distant lymph nodes, while the immunocompetency of distant lymph nodes (lower NCS concentration) showed slightly higher activity than that of proximal lymph nodes. From these results, it is suggested that loco-regional administration of NCS might be effective for chemical lymph node cleaning of the cancer.
Subject(s)
Colonic Neoplasms/drug therapy , Rectal Neoplasms/drug therapy , Stomach Neoplasms/drug therapy , Zinostatin/administration & dosage , Carbon , Chemotherapy, Adjuvant , Colonic Neoplasms/metabolism , Gastric Mucosa , Humans , Injections, Intralesional , Lymph Nodes/metabolism , Lymphocyte Activation , Rectal Neoplasms/metabolism , Stomach Neoplasms/metabolism , Zinostatin/pharmacokineticsSubject(s)
Stomach Neoplasms/drug therapy , Zinostatin/administration & dosage , Humans , Injections/methods , Lymph Nodes/metabolism , Lymph Nodes/pathology , Lymphatic Metastasis , Serous Membrane , Stomach , Stomach Neoplasms/metabolism , Stomach Neoplasms/pathology , Tissue Distribution , Zinostatin/pharmacokineticsABSTRACT
Out of 127 gastric cancer cases with a synchronous liver metastases, the relationship between the prognosis and the nuclear DNA contents in the primary and liver metastatic foci has been investigated in 10 relatively noncurative patients who had received a combined gastrectomy and hepatectomy. In 3 out of 5 long-term survival cases, low ploidy patterns were seen in both foci, whereas in 1 out of 5 short-term survival cases, a multiplicity was observed, i.e., a low ploidy in the primary focus and a high ploidy in the liver. In the other 4 short-term survival cases, high ploidy patterns were noted in both foci.
Subject(s)
DNA, Neoplasm/analysis , Gastrectomy , Hepatectomy , Liver Neoplasms/chemistry , Stomach Neoplasms/chemistry , Aged , Cell Nucleus/chemistry , Female , Gastrectomy/mortality , Hepatectomy/mortality , Humans , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Male , Middle Aged , Ploidies , Prognosis , Stomach Neoplasms/pathology , Stomach Neoplasms/surgery , Survival RateABSTRACT
A microspectrophotometric analysis of the DNA content has been performed on 9 advanced recurrent gastric cancer patients with measurable lesions, who has either been treated by CDDP alone or with other chemotherapeutics during a three-year period since, 1984. Histograms of the DNA content were classified into four ploidy patterns. All of the 4 responder cases (CR, PR, MR) showed type, IV, although only one of 5 non-responder cases revealed the same typing. In one of the two CR cases the DNA ploidy pattern, which was examined before and after the therapy, changed from type IV to type II. Thus it appears that an analysis of the DNA content may be useful in evaluating the effectiveness of different chemotherapies.
