[ESTIMATION OF PARAMETERS OF EXTERNAL RESPIRATION OF STUDENTS].

The close relationship of the respiratory system with other systems and organs, its significant participation in the processes of metabolism once again proves the exceptional role of the study of respiratory function. On the other hand, the health of students is one of the most important social tasks of modern society. The aim of the study was detection of parameters of external respiration in students of Georgia. 235 students 18 to 21 of ages, were involved in the study, who underwent computer spirometry with Spiro lab 3 to achieve the aim of study. The research among Georgian students has shown the external respiration function with the following characteristics: Pretest (females n=103) - VC=109.5±4.5%; FVC=99±5.25%; FEV1=104±3.60%; FEV1/VC=114.5±7.5%; PEF=74.5±0.79%; MEF 25%-75%=84±7,0%. Males (n=132) VC=99±5.25%; FVC=98±10.20%; FEV1=100±8.38%; FEV1/VC=104±1.41%; PEF=90±2.16; MEF 25%-75%=98±7.0%. Therefore, based on the research of Georgian students on computer spirometry external respiration function revealed the peculiarities of physiological parameters according to gender. The study, showed the need for the similar study among the variety of population in all age categories. It is really an actual issue for modern clinical medicine.

CORRELATION BETWEEN SPIROMETRY DATES AND SPECIAL ALLERGEN- SPECIFIC IGE IN PATIENTS WITH BRONCHIAL ASTHMA IN WEST GEORGIA.

The study aimed to establish correlation between airway obstruction and specific IgE specificity, managing future treatment in the patients with bronchial asthma, among the population of west Georgia. In the study have been involved 56 patients (among them 24 males and 32 females) of different ages, with diagnostic bronchial asthma (according to GINA recommendation). On the ground of the aim the study included the following steps of allegro-diagnostics: I step - Computerized spirometry by apparatus ,,SPIROLAB 3". II step - To detect allergenization degree, total serum IgE levels, specific IgE and concentration of Phadiatop, using modern automated system - "Immuno CAP 100", were estimated in the patients. III step- future treatment recommendations. All 56 patients were undergone the spirometry measurement. Our results show that of 56 patient 21 (38%) had very severe obstruction by spiromatry: Pretest: FEV 1 - 28%; FEF-45%; FEV1/FVC ratio -55% on average. Post test: significant bronchodilatation was revealed FEV1> +12%( >200 mL) after the inhalation of four puffs of a short - acting beta2 sympathomimetic agent, e.r., 400 µg of salbutamol. In 19 (33%) patients severe bronchoobstruction was established. By spiromometry was revealed: Pre test: FEV 1 - 42%; FEF-55%; FEV1/FVC ratio -67% on average. Post test: significant bronchodilatation was revealed FEV1> +12%( >200 mL) In 14 (25%) patients moderate bronchoobstruction was diagnosed, the spiromatry results were. Pretest: FEV 1 - 52%; FEF-65%; FEV1/FVC ratio - 67% on average. Post test: It was revealed significant bronchodilatation FEV1> +12%( >200 mL). Only in 2 (4%) patients were diagnosed the normal spiromatry. In the patients with bronchial asthma of a specific positivity of specific IgE to the weeds (Wx2) - ambrosia, plantain, clasp/tarragon, atriplex - in 23 (53%) on average; tree dust (Tx9) - alder, lactarius piperatus, nuts, oak, willow - 11 (19%); and cereals (Gx1) - festuca pratensis, lolium temulentum, timoti grass, poa - 9 (16%); Mx2 -Penicillium notatum, Cladosporium herbarum, Aspergillus fumigatus, Candida albicans, Alternaria alternate- 15 (21%) was revealed, only in 5 (9%) patients we cannot established the allergy specific IgE. It was established the correlation between spiromatry dates and special allergen specific IgE in patient with bronchial asthma. The latter is of great importance for providing the effective and safe allegro-specific immunotherapy (ASIT) and successful preventive measures.

[AEROPOLINOLOGIC MONITORING AND DISTRIBUTION OF ALLERGOALLERGENS IN WESTERN GEORGIA].

Climate and geographical conditions such as: air temperature, humidity and plant diversity represented in the region is of great importance for prevalence of allergic diseases. All these factors will maintain growing of allergization/sensitization of the body. It is known that allergic diseases (pollinosis, bronchial asthma), the highest percentage comes on the allergens- aeropolutants, that are represented in many plants and herbs in the form of dust (ragweed pollen, alder, birch, maple, walnut, mallow, cotton plant etc.). Thus, aeropolinologic study acquires special importance helping the clinicians to solve the following issues: which plant is common for the concrete region; what is the source of dust allergy; when are they particularly dangerous for the patient; when their dust is revealed and its concentrations in air pool or how they look. Georgia is the country with diverse flora and landscapes; the climate in Georgia varies across different parts of the country. Clinical and epidemiological studies have shown that the Western Georgia is characterized by the frequency of allergic diseases. The above raises the need to create a calendar of flowering plants in Imerety region of Georgia. 69 patients with allergic rhinitis and bronchial asthma from 7 to 60 years old (34 men and 35 women) were observed. The patients underwent allegro-diagnostic investigation. The results revealed high titers on weeds (WX2). On the basis of the conducted research annual calendar of aero-allergens spread in Imerety region was composed.

Cognitive correlates of leukoaraiosis in the early stages of Alzheimer's disease.

To reveal cognitive correlates of leukoaraiosis (LA) in the early stages of Alzheimer's disease (AD) and to exclude confounding effects of aging, brain atrophy, education and dementive illness on cognition, we carefully selected a sample of 37 probable AD patients (NINCDS-ADRDA criteria, Hachinski ischemic score < 5) with similar indices of age, educational level, degree of brain atrophy and dementia severity (CDR 0.5, CDR 1 and MMSE score no lower than 20), and compared the results of neuropsychological testing of patients with and without LA. All patients underwent magnetic resonance imaging. LA was detected in 17 out of 37 cases. There were no significant differences between subjects with and without LA (Student's t-test, p>0.05) in tests that evaluate language, verbal intelligence and visuospatial functions, while the patients with LA showed poorer performance (p<0.05) in the tests evaluating verbal memory, attention/concentration and executive functions. The results obtained suggest that the patients with LA in the early stages of AD revealed dorsolateral prefrontal dysfunction syndrome due to disconnection of cortico-subcortical circuits. We found this syndrome to be more prenounced than it has been described in the non-demented elderly with LA. It may be that in patients suffering from degenerative illness, the brain has fewer compensatory reserves than in cases of "normal" aging, and it is more sensitive to ischemic damage caused by cerebral amyloid, arteriosclerotic or fibro-hyalinotic angiopathy. This typical neuropsychological syndrome is revealed only in the initial stage of AD in patients with LA. The follow-up progress of the atrophic-degenerative illness leads to overlapping of the specific neuropsychological syndrome by global cognitive impairment.