[Comparative study of the effectiveness of the classical and modified Cooper protocol for breast cancer chemotherapy]. / Sravnitel'noe issledovanie éffektivnosti klassicheskoi i modifitsirovannoi skhem Kupera pri khimioterapii raka molochnoi zhelezy.

Efficiency of routine and modified Cuper procedures was studied after evaluation in saliva and urine of women with mammary gland tumor of the following parametres: alterations in dynamics of acrolein excretion with saliva, dynamics of alterations in calculated therapeutic doses of cyclophosphane administered using these procedures, dynamics of the ratio between non-metabolized cyclophosphane and its initial level in urine of the patients. Analysis of the data obtained suggest that the liver tissue enzymatic systems, involving in biotransformation of cyclophosphane, were distinctly less impaired during the modified Cuper procedure as compared with the routine course, thus corroborating advantages of the modified procedure used in chemotherapy of patients with mammary gland tumor.

[The effect of finoptin on the metabolism and pharmacological action of cyclophosphane in vivo and in vitro]. / Vliianie finoptina na metabolizm i farmakologicheskoe deistvie tsiklofosfana in vivo i in vitro.

Phynoptin (Ph) and cyclophosphamide (CP) gave rise to a type I spectral changes with liver microsomal fraction. KS were 15 microM and 2150 microM, respectively. Ph increases the concentration of NBP product(s) of CP and acrolein in the blood plasma of animals. Ph increases a toxicity of CP. LD50 was 388.0 +/- 13.9 mg/kg for CP and LD50 was 342.8 +/- 16.9 mg/kg for CP in combination with Ph. Ph changes a therapeutic action of CP in mice with hemocytoblastosis La. Pharmacokinetic interactions have been demonstrated between calcium antagonists Ph and CP.