ABSTRACT
In an open design study of fifty-four patients with grade I or grade II acne vulgaris, the combination of 0.1 percent tretinoin cream (Retin-A) and a sunscreen with sun protection factor 15 (Sundown) was evaluated. Overall study results of the forty-six patients who could be evaluated demonstrated a decrease in papule count of 25.9 percent, a decrease in closed comedones of 49.1 percent, and a decrease in open comedones of 36.3 percent by the end of the eight-week study period. These results indicate that the addition of a noncomedogenic sunscreen to tretinoin did not compromise its effectiveness and successfully prevented photoaccentuation reactions.
Subject(s)
Acne Vulgaris/drug therapy , Sunscreening Agents/therapeutic use , Tretinoin/administration & dosage , Adolescent , Adult , Child , Drug Combinations , Female , Follow-Up Studies , Humans , Male , Photosensitivity Disorders/chemically induced , Photosensitivity Disorders/prevention & control , Tretinoin/adverse effectsABSTRACT
The comparative effectiveness of an abrasive cleaner and the same cleansing agent without the abrasive granules was evaluated using a bilateral paired comparison method in 44 patients with acne vulgaris. Lesion counts and an appraisal of the severity of disease were made every two weeks for a total of eight weeks. An equal reduction in both the number and severity of acne lesions was seen with each test product. Substantial differences between the adverse effects of these two products were not observed.
Subject(s)
Acne Vulgaris/therapy , Dermabrasion/methods , Acne Vulgaris/diagnosis , Adolescent , Adult , Female , Humans , MaleABSTRACT
The mineral metabolism of healing arterial walls was studied by measuring the accumulation of several radioisotopes at the site of vascular repair in rats. Each rat was subjected to a 1-cm full-thickness aortotomy and then immediately injected by tail vein with c 5 muCi of one of the following radioisotopes: chromic chloride Cr 51 or sodium chromate Cr 51; ferrous chloride Fe 59 or ferric chloride Fe 59; manganous chloride Mn 54; selenious acid Se 75; strontium chloride Sr 85; or zinc chloride Zn 65. At intervals of 1, 2, 4, 6, and 10 days after operation and injection, groups of four rats for each radioisotope were killed, aortas dissected, and the specific radioactivity of healing vascular tissue compared with that of adjacent normal artery. There were sharp and statistically significant differences in the preferential accumulation of the radioisotopes in healing compared with normal aorta. Zinc appeared to be the element most involved in vascular repair, followed by selenium and chromium.
Subject(s)
Arteries/metabolism , Minerals/metabolism , Wound Healing , Animals , Aorta/metabolism , Arteries/injuries , Chromium/metabolism , Chromium Radioisotopes/metabolism , Copper/metabolism , Iron/metabolism , Iron Radioisotopes , Male , Manganese/metabolism , Parenteral Nutrition , Radioisotopes , Rats , Selenium/metabolism , Strontium/metabolism , Strontium Radioisotopes , Zinc/metabolism , Zinc RadioisotopesABSTRACT
Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization. Although three of eight developed negative patch tests and were presumed to be desensitized, only one patient was able to use the drug therapeutically, and then only for a period of eight months, after which allergy recurred. The other two patients whose allergic contact dermatitis was abolished by the infusions were unable to use mechlorethamine therapeutically because of pruritus. Seven patients experienced some adverse reaction to the infusion. Intravenous desensitization of psoriatic patients who are allergic to mechlorethamine was not successful enough as a useful clinical procedure to allow them to once again use the drug therapeutically.
