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1.
Prev Vet Med ; 69(1-2): 77-95, 2005 Jun 10.
Article in English | MEDLINE | ID: mdl-15899298

ABSTRACT

We developed a dynamic model of livestock-to-human brucellosis transmission in Mongolia. The compartmental model considers transmission within sheep and cattle populations and the transmission to humans as additive components. The model was fitted to demographic and seroprevalence data (Rose Bengal test) from livestock and annually reported new human brucellosis cases in Mongolia for 1991-1999 prior to the onset of a mass livestock-vaccination campaign (S19 Brucella abortus for cattle and Rev 1 Brucella melitensis for sheep and goat). The vaccination effect was fitted to livestock- and human-brucellosis data from the first 3 years of the vaccination campaign (2000-2002). Parameters were optimized on the basis of the goodness-of-fit (assessed by the deviance). The simultaneously fitted sheep-human and cattle-human contact rates show that 90% of human brucellosis was small-ruminant derived. Average effective reproductive ratios for the year 1999 were 1.2 for sheep and 1.7 for cattle.


Subject(s)
Brucellosis/veterinary , Cattle Diseases/transmission , Models, Statistical , Sheep Diseases/transmission , Zoonoses , Animals , Brucellosis/transmission , Cattle , Cattle Diseases/epidemiology , Cattle Diseases/prevention & control , Humans , Mongolia/epidemiology , Sheep , Sheep Diseases/epidemiology , Sheep Diseases/prevention & control , Vaccination/veterinary
2.
Bull World Health Organ ; 81(12): 867-76, 2003.
Article in English | MEDLINE | ID: mdl-14997239

ABSTRACT

OBJECTIVE: To estimate the economic benefit, cost-effectiveness, and distribution of benefit of improving human health in Mongolia through the control of brucellosis by mass vaccination of livestock. METHODS: Cost-effectiveness and economic benefit for human society and the agricultural sector of mass vaccination against brucellosis was modelled. The intervention consisted of a planned 10-year livestock mass vaccination campaign using Rev-1 livestock vaccine for small ruminants and S19 livestock vaccine for cattle. Cost-effectiveness, expressed as cost per disability-adjusted life year (DALY) averted, was the primary outcome. FINDINGS: In a scenario of 52% reduction of brucellosis transmission between animals achieved by mass vaccination, a total of 49,027 DALYs could be averted. Estimated intervention costs were US$ 8.3 million, and the overall benefit was US$ 26.6 million. This results in a net present value of US$ 18.3 million and an average benefit-cost ratio for society of 3.2 (2.27-4.37). If the costs of the intervention were shared between the sectors in proportion to the benefit to each, the public health sector would contribute 11%, which gives a cost-effectiveness of US$ 19.1 per DALY averted (95% confidence interval 5.3-486.8). If private economic gain because of improved human health was included, the health sector should contribute 42% to the intervention costs and the cost-effectiveness would decrease to US$ 71.4 per DALY averted. CONCLUSION: If the costs of vaccination of livestock against brucellosis were allocated to all sectors in proportion to the benefits, the intervention might be profitable and cost effective for the agricultural and health sectors.


Subject(s)
Bacterial Vaccines/administration & dosage , Brucellosis/veterinary , Cattle Diseases/prevention & control , Cost-Benefit Analysis , Sheep Diseases/prevention & control , Zoonoses/transmission , Animals , Animals, Domestic , Bacterial Vaccines/economics , Brucellosis/economics , Brucellosis/prevention & control , Brucellosis/transmission , Cattle , Cattle Diseases/economics , Cattle Diseases/transmission , Cost Sharing , Cost of Illness , Humans , Mongolia , Outcome Assessment, Health Care , Sheep Diseases/economics , Sheep Diseases/transmission
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