ABSTRACT
Nonsteroidal anti-inflammatory drugs induce the inhibition of prostaglandin synthesis, which can cause constriction of the fetal ductus arteriosus in the pregnancy. We report two cases of antenatal closure of ductus arteriosus with severe pulmonary hypertension following maternal ingestion of nonsteroidal anti-inflammatory drugs (niflumic acid and acetylsalicylic acid) in the last days before delivery. To our knowledge, this is only the second case in literature describing antenatal closure of ductus arteriosus after the administration of niflúmic acid. Prescription of nonsteroidal anti-inflammatory drugs must be avoided during pregnancy. Fetal echocardiography must be monitored in those women treated with nonsteroidal anti-inflammatory drugs.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Hypertension, Pulmonary/chemically induced , Niflumic Acid/adverse effects , Prenatal Exposure Delayed Effects/epidemiology , Adult , Female , Humans , Hypertension, Pulmonary/diagnosis , Infant, Newborn , Male , PregnancyABSTRACT
Los antiinflamatorios no esteroideos inhiben la síntesis de prostaglandinas y producen una vasoconstricción del conducto arterioso fetal durante la gestación. Presentamos los casos de dos recién nacidos con hipertensión pulmonar grave secundaria a cierre ductal. En las semanas previas al parto, una de las madres había recibido tratamiento con ácido acetilsalicílico y la otra, con ácido niflúmico. Éste es el segundo caso descrito en la literatura médica de cierre ductal intraútero tras administración de ácido niflúmico. La ingestión de antiinflamatorios no esteroideos durante el embarazo está desaconsejado. No obstante, en las gestantes tratadas se debe realizar una monitorización continua, y la ecocardiografía fetal es de gran utilidad (AU)
Nonsteroidal anti-inflammatory drugs induce the inhibition of prostaglandin synthesis, which can cause constriction of the fetal ductus arteriosus in the pregnancy. We report two cases of antenatal closure of ductus arteriosus with severe pulmonary hypertension following maternal ingestion of nonsteroidal anti-inflammatory drugs (niflumic acid and acetylsalicylic acid) in the last days before delivery. To our knowledge, this is only the second case in literature describing antenatal closure of ductus arteriosus after the administration of niflúmic acid. Prescription of nonsteroidal anti-inflammatory drugs must be avoided during pregnancy. Fetal echocardiography must be monitored in those women treated with nonsteroidal anti-inflammatory drugs (AU)
Subject(s)
Humans , Male , Female , Infant, Newborn , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Persistent Fetal Circulation Syndrome/chemically induced , Niflumic Acid/adverse effects , Hypertension, Pulmonary/chemically inducedABSTRACT
La asociación de la tríada oligofrenia, ictiosis congénita e hipogonadismo constituye el síndrome de Rud, entidad con muy pocos casos en la literatura médica mundial. Se han descrito en estos pacientes otras alteraciones menos frecuentes, como crisis convulsivas, epilepsia, talla baja, retinitis pigmentosa, polineuropatía hipertrófica o sordera neurosensorial. Forma parte de los denominados síndromes neurocutáneos queratósicos, junto con otros mejor definidos, como el síndrome de Sjögren-Larson o la enfermedad de Refsum. Se expone el caso de un paciente de 13 años de edad, con criterios clínicos compatibles con el síndrome de Rud, que asocia una agenesia renal unilateral y un sarcoma de partes blandas
The triad of oligophrenia, congenital ictiosis and hypogonadism constitutes Rud´s syndrome, and entity that is rarely reported in the world medical literature. Other less common festures such as seizures, epilepsy, short stature, retinitis pigmentosa, hypertrophic plyneuropathy or neurosensory hearing loss have also been reported in these patients. Rud´s syndrome is one of the so-called keratotic neurocutaneous syndromes, which include other better defined entities such as Sjögren-Larsson syndrome and Refsum disease. We report the case of a 13-years-old boy who met the clinical criteria for Rud´s syndrome, which was associated with unilateral renal agenesis and the development of a soft tissue sarcoma
Subject(s)
Male , Child , Humans , Mucopolysaccharidosis III/complications , Ichthyosis/complications , Keratosis/complications , Keratosis/surgery , Hypogonadism/complications , Hypogonadism/diagnosis , Dwarfism/complications , Biopsy/methods , Sarcoma, Clear Cell/complications , Sarcoma, Clear Cell/diagnosis , Abnormalities, Multiple/genetics , Sarcoma/complications , Keratosis/diagnosis , Sarcoma/diagnosis , Growth Disorders/genetics , Hyperbilirubinemia/complications , Hyperbilirubinemia/diagnosis , Intellectual Disability/complicationsABSTRACT
Complete aortic thrombosis is rare in neonates. Because it carries high morbidity and mortality, this entity requires aggressive and early treatment. This report describes an 8-day-old healthy and exclusively breast-fed infant, without specific coagulopathy, who developed complete aortic and cerebral venous thrombosis, which was attributed to inadequate breast-feeding and severe hypernatremic dehydration. Early systemic anticoagulation and thrombolytic therapy allowed complete resolution of the problem.
Subject(s)
Aortic Diseases/etiology , Dehydration/complications , Hypernatremia/etiology , Intracranial Thrombosis/etiology , Thrombosis/etiology , Anticoagulants/therapeutic use , Aorta/diagnostic imaging , Aorta/pathology , Aortic Diseases/diagnostic imaging , Aortic Diseases/drug therapy , Breast Feeding , Cerebral Angiography , Dehydration/therapy , Humans , Hypernatremia/therapy , Infant, Newborn , Intracranial Thrombosis/diagnosis , Intracranial Thrombosis/drug therapy , Magnetic Resonance Imaging , Male , Thrombosis/diagnosis , Thrombosis/drug therapy , Treatment Outcome , UltrasonographyABSTRACT
La trombosis aórtica completa es una entidad rara en el período neonatal, precisando tratamiento agresivo de forma precoz debido a la alta morbimortalidad que asocia. Se presenta el caso de un recién nacido de 8 días de vida, sano y sin antecedentes de interés ni coagulopatía asociada, alimentado con lactancia materna de forma exclusiva, que presentó una trombosis aórtica masiva y venosa cerebral secundaria a una deshidratación hipernatrémica grave. La instauración precoz de tratamiento fibrinolítico y anticoagulante permitió la resolución completa del cuadro
Complete aortic thrombosis is rare in neonates. Because it carries high morbidity and mortality, this entity requires aggressive and early treatment. This report describes an 8-day-old healthy and exclusively breast-fed infant, without specific coagulopathy, who developed complete aortic and cerebral venous thrombosis, which was attributed to inadequate breast-feeding and severe hypernatremic dehydration. Early systemic anticoagulation and thrombolytic therapy allowed complete resolution of the problem