ABSTRACT
A 44-year-old women developed marked myopathy one year earlier, when she was treated with intravenous prednisolone for acute severe exacerbation of ulcerative colitis. When she was admitted to our hospital for another severe exacerbation, intravenous cyclosporine A was administered as monotherapy because she could not tolerate corticosteroid. The treatment was successful and she obtained complete remission. Cyclosporine A monotherapy is considered to be a valuable alternative to proctocolectomy for severe ulcerative colitis patients who cannot tolerate corticosteroid.
Subject(s)
Colitis, Ulcerative/drug therapy , Cyclosporine/administration & dosage , Immunosuppressive Agents/administration & dosage , Prednisolone/administration & dosage , Prednisolone/adverse effects , Adult , Female , Humans , Infusions, Intravenous , Mercaptopurine/administration & dosage , Treatment OutcomeABSTRACT
A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level.
Subject(s)
Bone Marrow/drug effects , Crohn Disease/drug therapy , Immunosuppressive Agents/adverse effects , Mercaptopurine/adverse effects , Neutropenia/chemically induced , Abscess/etiology , Adult , Anus Diseases/etiology , Crohn Disease/complications , Drug Therapy, Combination , Granulocyte Colony-Stimulating Factor/therapeutic use , Humans , Ileitis/etiology , Leukocyte Count , Male , Mesalamine/administration & dosageABSTRACT
A 23-year-old woman was admitted in November, 2002, complaining pain of the left side and buttock. She had ulcerative colitis when she was 16 and received medical treatment. Based on physical examination and findings of magnetic resonance imaging and bone scintigrapy, as sacroiliitis complicated by ulcerative colitis. was diagnosed Reports on sacroiliitis and ankylosing spondylitis complicated by inflammatory bowel diseases (IBD) are relatively rare in Japan, whereas they are common complications of IBD in Western countries. The efficacy of steroids on pain relief of sacroiliitis and ankylosing spondylitis is unclear.
