ABSTRACT
Se ha desarrollado un modelo topológico-matemático encaminado a buscarnuevos compuestos derivados del 3,5 dinitrobenceno sulfonamida y/o benzamidaactivos frente a Leishmania. Utilizando el análisis lineal discriminante y el análisisde regresión multilineal se ha obtenido un modelo capaz de identificar la actividaddel 90% de los compuestos estudiados. Tras realizar un barrido virtual se proponennuevas estructuras potencialmente activas frente a L donovani
A topological-mathematical model has been arranged to search for newderivatives of 3,5-dinitrobenzene sulphonamide and/or benzamide, active againstL. donovani. By using linear discriminant analysis as well as multilinear regression,a model capable to identify the activity of 90% of the analyzed compounds hasbeen achieved. After carrying out a virtual screening based upon such a model, newstructures potentially active against the parasite are proposed
Subject(s)
Humans , Molecular Biology/methods , Leishmania/chemistry , Models, Theoretical , Leishmania donovani/chemistry , Leishmania donovani/microbiology , Discriminant Analysis , Sulfonamides/pharmacology , Sulfonamides/therapeutic use , Logistic Models , Regression Analysis , Immunosuppression Therapy/methodsABSTRACT
We report on a case with a partial monosomy for the regions 9p23 --> pter and 13p11 --> pter as a result of a de novo translocation (9p23;13p11). The patient, a 16-year-old girl, has mental deficiency, obesity, and minor anomalies, including trigonocephaly, hypertelorism and a short, broad neck. Cytogenetic and microsatellite marker analysis allowed us to assign the breakpoint to the chromosomal region 9p23, flanked by the markers D9S144 and D9S157. In an attempt to establish a phenotype-genotype correlation, the clinical manifestations present in our patient are compared to those with partial 9p monosomy and breakpoint in p23, referred to in the literature.
