Secondary and tertiary hyperparathyroidism: role of preoperative localization.

BACKGROUND: The usefulness of both technetium Tc-99m sestamibi (MIBI) scintigraphy and ultrasonography (USG) scan for the detection of enlarged parathyroid glands secondary to renal hyperparathyroidism is rarely addressed. METHODS: A retrospective study from July 1999 to June 2005 was carried out on patients with secondary and tertiary hyperparathyroidism to determine the role of preoperative localization. RESULTS: In the 5 years, 73 patients with renal hyperparathyroidism underwent initial bilateral neck exploration with total parathyroidectomy. Four patients underwent neck exploration with parathyroidectomy for persistent hyperparathyroidism. Two patients underwent neck exploration with parathyroidectomy for recurrent hyperparathyroidism. For patients with initial secondary/tertiary hyperparathyroidism, MIBI scintigraphy correctly showed 101 of 276 (36.6%) surgically confirmed enlarged parathyroids, whereas USG scan showed 99 of 276 (35.9%) surgically confirmed enlarged parathyroids. For persistent or recurrent secondary/tertiary hyperparathyroidism, MIBI scintigraphy and USG scan had sensitivity of 100 and 50%, respectively. CONCLUSIONS: In conclusion, preoperative localization studies have a limited value when used before first neck exploration in secondary/tertiary hyperparathyroidism because of the poor results in identifying all parathyroid glands. In persistent/recurrent hyperparathyroidism, it may play a useful role in localization of the missed or ectopic parathyroid gland.

Diagnostic accuracy of 2-[fluorine-18]fluro-2-deoxy-D-glucose positron emission tomography imaging in nonsquamous tumors of the head and neck.

PURPOSE: To evaluate the diagnostic accuracy of 2-[fluorine-18]fluro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for detecting nonsquamous tumors of the extracranial head and neck (NSTHN). MATERIALS AND METHODS: The records of all patients with suspected or proven NSTHN undergoing PET imaging in our institution over a 12-year period were reviewed. Forty-four patients (24 males and 20 females; age range, 6-81 years; mean age, 51.2 years) were classified into 3 main groups: thyroid tumors (n = 19), salivary gland tumors (n = 7), and miscellaneous lesions (n = 18). The PET findings for each individual group with respect to the primary site, cervical nodal and distant metastases, were correlated with histopathology or follow-up (2-year minimum) RESULTS: The overall diagnostic accuracy of FDG-PET for all NSTHN was 86%, However, the diagnostic accuracy varied for the histologic subtype (thyroid, salivary, miscellaneous) and the area being evaluated (primary site, nodal metastases, distant metastases). CONCLUSION: There is variable diagnostic accuracy of FDG-PET in detecting different histologic subtypes of NSTHN. This information should be taken into consideration when considering PET for evaluation of NSTHN.

Hypodensity of >1/3 middle cerebral artery territory versus Alberta Stroke Programme Early CT Score (ASPECTS): comparison of two methods of quantitative evaluation of early CT changes in hyperacute ischemic stroke in the community setting.

BACKGROUND: The one third middle cerebral artery territory ((1/3) MCA) method and the Alberta Stroke Program Early CT Score (ASPECTS) were used to detect significant early ischemic changes (EIC) on CT brain of acute stroke patients. We sought to compare the reliability of the 2 methods in routine clinical practice. METHODS: Eighty consecutive patients admitted to a community hospital in Hong Kong with suspected acute ischemic stroke and a CT brain scan performed within 6 hours of symptom onset were included. Five blinded observers (1 neurologist, 2 general radiologists, and 2 neuroradiologists) independently evaluated the scans, using the ATLANTIS/CT Summit criteria for >(1/3) MCA involvement, and ASPECTS (1/3) MCA involvement, all observers agreed in 57 cases (71%), with moderate interobserver agreement (kappa=0.49). For ASPECTS