1.
Eur J Med Chem
; 38(9): 811-24, 2003 Sep.
Article
in English
| MEDLINE
| ID: mdl-14561480
ABSTRACT
New styryl sulfone compounds have been synthesized and evaluated for their anti-proliferative activity. Among the compounds synthesized, one compound (7k) has shown 51% tumor growth inhibition in mice implanted with HT-29 human carcinoma at 400 mg kg(-1) orally.
Subject(s)
Antineoplastic Agents/pharmacology , Sulfones/pharmacology , Animals , Antineoplastic Agents/chemical synthesis , Cell Division/drug effects , HT29 Cells , Humans , Mice , Mice, Nude , Molecular Structure , Sulfones/chemical synthesis , Xenograft Model Antitumor Assays
2.
Eur J Med Chem
; 37(4): 339-47, 2002 Apr.
Article
in English
| MEDLINE
| ID: mdl-11960669
ABSTRACT
New 3-O-substituted benzyl pyridazinone compounds have been synthesised and evaluated for their cyclooxygenase inhibitory activity and COX-2 selectivity. Among the compounds synthesised, three compounds (11b-11d) have shown in vitro COX-2 selectivity. These compounds have been evaluated for their in vivo potential using carrageenan-induced rat paw edema assay. One compound (11b) showed 32% anti-inflammatory activity at 30 mgkg(-1) dose.
