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4.
J AAPOS ; 27(6): 377-378, 2023 12.
Article in English | MEDLINE | ID: mdl-37871794

ABSTRACT

We report the case of a 15-year-old boy with severe inflammatory blepharitis who was being treated with a TNFα inhibitor for Crohn's disease (CD). This case shows the potential utility of a skin biopsy in distinguishing metastatic CD associated with granulomatous blepharitis from a paradoxical blepharitis induced by anti-TNFα. It also demonstrates that ustekinumab can be considered in patients with CD who cannot tolerate TNFα inhibitors because of cutaneous paradoxical reactions.


Subject(s)
Crohn Disease , Male , Humans , Adolescent , Crohn Disease/complications , Crohn Disease/drug therapy , Tumor Necrosis Factor-alpha , Ustekinumab , Skin/pathology , Biopsy
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