Pain and Transcranial Direct Current Stimulation: A Bibliometric Analysis.

Context: Pain management is a constant struggle. Transcranial direct current stimulation (tDCS) is a neuromodulation technique with proved efficacy in chronic pain. Objective: The aim of the study is to provide a bibliometric perspective regarding articles on pain and tDCS. Having a visualized and systematically overview of publication trends, new research ideas could arise for clinicians. Methods: Articles on pain and tDCS were retrieved from Web of Science database. Using the R software version 4.1.2 and the "biblioshiny" R package, a quantitative and statistical analysis was performed. Time trend, number of publications, journals and authors, author country and institution, as well as citations and references were visualized. Results: A total of 554 publication fulfilled the criteria and were analyzed. The scientific production has been increasing over time with an annual growth of 17.1%. Brain Stimulation Journal and Journal of Pain are the leading journals regarding articles and citations. Fregni F. (83 articles) is the most prolific researcher with important authorship in the field. USA is the country with most authors involved in the topic (558 authors), whereas the leading institution is represented by Universidade Federal Rio Grande Do Sul (84 articles). Lefaucheur JP. article from 2017 has the maximum citations, while keywords in trend in the last three years are osteoarthritis and low back pain. Conclusion: This is the first bibliometric study that reflects the trends of tDCS in the field of pain. Journals as well as authors are limited and clustered. However the number of articles as well as number of citations are constantly increasing, supporting the idea that this is an emerging topic. The information obtained could be an important practical basis for future pain management research.

Cancer Pain and Non-Invasive Brain Stimulation-A Narrative Review.

Background and Objectives: Pain is the most prevalent symptom in cancer patients. There is a paucity of data regarding non-invasive brain stimulation (NIBS) for the treatment of chronic pain in patients with cancer. The purpose of this article is to review the techniques of NIBS and present the published experiences of the oncological population. Materials and Methods: Databases including MEDLINE, Scopus, Web of Science, and the Cochrane Library were searched for articles on cancer patients with pain that was managed with non-invasive brain stimulation techniques. We included articles in English that were published from inception to January 2023. As studies were limited in number and had different designs and methodologies, a narrative review was considered as the best option to integrate data. Results: Four studies focusing on transcranial magnetic stimulation, six articles on transcranial direct current stimulation, and three articles regarding cranial electric stimulation were found and reviewed. Conclusions: Data are limited and not robust. Further studies in this field are required. Guidelines on NIBS for non-malignant chronic pain conditions provide good premises for cancer-related chronic pain.

Insomnia in cancer patients - A survey of health-care professionals' views and current practice in Romania.

BACKGROUND: Changes in the quality of sleep are reported often in cancer patients and have a major impact on general health. However, insomnia tends to be insufficiently evaluated and managed. AIM: The aim of the study was to analyze the perception of clinical staff working in oncology units regarding patients' sleep disorders. Furthermore, we assessed the prevalence of insomnia in this category of professionals. MATERIALS AND METHODS: The study was cross sectional and used a descriptive and correlational design. Clinical personnel working in oncology departments were invited to complete a questionnaire regarding sleep problems in patients, and optionally, the Pittsburgh sleep quality index questionnaire was administered. Correlations between age, profession, experience, and their responses were statistically analyzed. RESULTS: We gathered 101 responses, with 63.4% coming from doctors. With one exception, all professionals observed changes in sleep patterns in patients, but less than a third were actively looking for these problems and only three health professionals used questionnaires. No significant differences in answers were noted based on age, profession, or experience. Regarding professionals, 45.6% of them had impaired sleep based on the Pittsburgh questionnaire results. CONCLUSION: Oncology staff are aware of the existence and impact of sleep problems, but active assessment for sleep problems is low. There is a relative high prevalence of poor sleep quality among oncology staff. In order to improve the well-being of patients, the quality of sleep should be documented as part of the care plan. The existence of guidelines is desirable.

Psychological stress and breast cancer incidence: a systematic review.

OBJECTIVE: Breast cancer is the world's leading cause of cancer mortality in women. Stress is an imminent risk factor with a documented negative impact on neuro-endocrine and immune system. Numerous epidemiological studies have investigated the link between stress and cancer, reporting contradictory results from no association to a close causal link. The impact of the topic and the lack of conclusion compelled this systematic review. METHODS: A systematic review was carried out, including all literature studies from 1966 to 2016, investigating the relationship between stress and the occurrence of breast cancer. Of the 1813 articles identified in the PubMed/Medline database, 52 were eligible and included in the analysis. RESULTS: A number of 17 retrospective, 20 limited prospective and 15 prospective studies were analyzed. The number of patients exceeded 29,000, for a total number of more than 700.000 women recruited from hospital, screening cohorts or population registers. We identified 26 positive articles linking personal traits, stressful events and breast cancer, 18 negative articles that did not confirm their hypothesis and 8 articles that could not be classified. Facing heterogeneity, all possible misguiding factors such as: study design, information gathering, stress type, moment of exposure, individual susceptibility and personality, were discussed independently. CONCLUSIONS: Qualitative analysis of articles has revealed a possible association between stress and cancer, especially regarding stressful life events. In the absence of a meta-analysis and taking into account the methodological heterogeneity of the studies, the results are difficult to interpret and the role of chance is difficult to exclude.