ABSTRACT
In order to asses the role of the soluble mediators of serum from patients with SLE in the apoptotic cell clearance, we measured the in vitro phagocytosis of apoptotic Jurkat cells by normal healthy donor macrophages in the presence of SLE patients' sera. A significant increase of the phagocytic index (NHD = 1.0 +/- 0.3; SLE = 1.9 +/- 0.6; p < 0.01) was to be observed in the presence of serum from patients with SLE. The increased phagocytic index correlated to the anti-dsDNA antibodies titers. We conclude that anti-dsDNA antibodies present in sera of patients with SLE favor the apoptotic cell phagocytosis by opsonization of the target cells. This may represent a deviation of the clearance process towards inflammation and a new pathologic feature of these autoantibodies in SLE.
Subject(s)
Antibodies, Antinuclear/immunology , Apoptosis/immunology , Lupus Erythematosus, Systemic/immunology , Macrophages/immunology , Phagocytosis/immunology , Antibodies, Antinuclear/blood , Humans , Jurkat Cells , Lupus Erythematosus, Systemic/bloodABSTRACT
It is presented a child with Hodgkin's disease which at diagnosis present associated at nephrotic syndrome. Male of nine years old which present a ganglionic growing of left jugular chain of one year evolution without systemic symptoms and anasarca. Were underwent a ganglionic biopsy with histopathology report of Hodgkin's disease mixed cellular variety and renal biopsy with histopathology report of minimal change disease. The patient present remission of nephrotic syndrome in simultaneous form at the control of the disease. In the reported cases of nephrotic syndrome associated with Hodgkin's disease it not clear the physiopathology. In this patient were realized immunologic studies of renal tissues to treat to find a possible mechanism of action of the neoplastic cells on the basal glomerular membrane but we can not found.
Subject(s)
Hodgkin Disease/diagnosis , Nephrotic Syndrome/diagnosis , Biopsy , Bone Marrow/pathology , Child , Chronic Disease , Combined Modality Therapy , Hodgkin Disease/therapy , Humans , Kidney/pathology , Lymph Nodes/pathology , Male , Nephrotic Syndrome/therapySubject(s)
Hodgkin Disease/pathology , Adolescent , Child , Child, Preschool , Combined Modality Therapy , Female , Hodgkin Disease/classification , Hodgkin Disease/therapy , Humans , Male , PrognosisABSTRACT
On a prospective fashion during approximately two years, 22 pediatric patients with acute non lymphocytic leukemia were evaluated. Of this population the majority had acute mielocytic leukemia, followed by acute myelomonocytic leukemia. Absolutely all patients at the time of diagnosis and subsequently every 4 to 6 weeks had a bone marrow aspiration test. When the patients were first seen, 54% of them presented fever; lymph node enlargement was not a common finding. Only few of this patients presented splenomegaly and/or hepatomegaly. In regards to complete blood counts the most outstanding of its was the presence of leukocyte count above 20000/mm.3 in 8 of this patients. From the 22 patients studied only 21 are evaluable. All 21 patients were treated with a 4 drug combination (modified COAP). Sixteen patients (76%) achieved bone marrow remission, of which only 15 patients (71%) achieved complete remission. The median duration remission was of 9.2 months with a range of 2 to 26 months. At the present time only 7 patients (33%) are alive and on remission. Two more patients are alive but in full relapse. The mortality rate of this study is of 59%. The review of recent chemotherapy reports is presented and the need for further trials is emphasized especially in view of recent papers published in which it appears that better results are being obtained at last in children's acute non lymphocitic leukemia.
Subject(s)
Antibiotics, Antineoplastic/therapeutic use , Leukemia, Monocytic, Acute/drug therapy , Leukemia, Myeloid, Acute/drug therapy , Adolescent , Child , Child, Preschool , Drug Evaluation , Drug Therapy, Combination , Female , Humans , Injections, Intravenous , MaleABSTRACT
A description is made of the correlation between symptomatology and survivorship in 50 cases of malignant reticuloendotheliosis grouped as follows: 1. Cases with a single bone lesion, with several bony lesions, with lesions in bones and in soft tissues and with lesions only in soft tissues. 2. Each symptom is given the value of 1 and with the resulting addition, a rate is established. In the first part, it was found that survivorship was better in those groups that only showed bony lesion and within them, in those with a single lesion. The worst survivorship was for those cases with lesion only in soft tissues. In the second part, it was shown that survivorship was definitely less for cases with higher rating. Based on the previously described, this classification and rating is proposed to establish an earlier and more exact prognosis than usual.
Subject(s)
Bone Neoplasms/diagnosis , Lymphatic Diseases/diagnosis , Soft Tissue Neoplasms/diagnosis , Child , Child, Preschool , Female , Humans , Infant , Male , Prognosis , Sex FactorsABSTRACT
The relationship of age, sex, clinical findings and prognosis was studied among 30 children with malignant reticuloendotheliosis. A male predominance was found, but it was not possible to make any prognostic correlation regarding this parameter. A definitive worse prognosis was found in the early ages, thus 88% of less than 12 months-old children died. Although the visceral involvement degree signifies a poor prognosis, it was found that nevertheless, a solitary osteolytic lesion is in the accordance with good prognosis; all patients who did not have bone lesions died in less than three years. It is the first part of our purpose to enact the usefulness of the clinical findings toward a more precise prognosis in the malignant reticuloengotheliosis. Later on, we will report the possibility to obtain a numerical data from the clinical findings in order to establish an accurate prognosis.
