ABSTRACT
During 50 days a group of 23 volunteers received lunches prepared on the basis of textured proteins of soy beans. Each lunch included 50 g of proteins. Laboratory investigation was carried on dynamic values of lipid metabolism, cell-mediated, humoral and local immunity. A total of more than 30 tests were made. The analysis of immunological reactivity in volunteers has revealed the immunomodulatory activity of soy bean protein similar to the reference modulator with known quantitative estimation of effects on cell mediated, humoral and local immunity. Statistic analysis of preliminary individual laboratory results and plotting of prognostic curves allowed to develop an original method of volunteer selection for whom soy bean diet may bring positive or negative results.
Subject(s)
Diet , Glycine max , Immunity/drug effects , Soybean Proteins/pharmacology , Adjuvants, Immunologic/physiology , Adult , Antibody Formation/drug effects , Female , Humans , Immunity, Cellular/drug effects , Lipid Metabolism , Male , Middle Aged , Prognosis , Soybean Proteins/metabolismABSTRACT
71 patients with nonspecific diseases of the colon were examined before and after hemosorption for concentrations of seromucoid, orosomucoid, immunoglobulins G,M,A, C3 and C4 complement component fractions, haptoglobin, ceruloplasmin, alpha 1-antitrypsin, C-reactive protein, properdin, transferrin. It was found that hemosorption results in lowering of all the above concentrations in nonspecific ulcerative colitis, except seromucoid and orosomucoid in moderate and acute colitis. In response to hemosorption serum glycoproteins levels varied with the disease severity, its duration and metabolic activity of the liver. Concentrations of seromucoids, orosomucoid, alpha 1-antitrypsin changed in correlation with clinical manifestations of colon inflammation and may serve as criteria of hemosorption efficacy.
Subject(s)
Colitis, Ulcerative/blood , Colitis, Ulcerative/therapy , Crohn Disease/blood , Crohn Disease/therapy , Glycoproteins/blood , Hemoperfusion , Acute-Phase Proteins/analysis , Adolescent , Adult , Aged , Female , Humans , Immunochemistry , Male , Middle Aged , Time FactorsABSTRACT
Results of treatment of 32 patients with phlegmons of the face and neck with the use of reinfusion of UV irradiated blood (RUVIB) are presented. RUVIB was found to exert positive influence upon metabolic processes and thus it created the optimum conditions for the functioning of the immune system improving the clinical effects of the treatment.
Subject(s)
Blood Transfusion, Autologous , Blood/radiation effects , Cellulitis/therapy , Facial Dermatoses/therapy , Immunity/radiation effects , Ultraviolet Therapy , Adult , Cellulitis/immunology , Combined Modality Therapy , Complement System Proteins/radiation effects , Facial Dermatoses/immunology , Female , Focal Infection, Dental/complications , Humans , Immunity, Cellular/radiation effects , Immunoglobulins/analysis , Male , Middle AgedABSTRACT
The authors analyzed immunological changes in 56 patients with chronic colon stasis at the compensated and decompensated stages. Clinicoimmunological investigation of these patients permitted the detection of considerable changes in the system of homeostasis against a background of chronic inflammation of the colon mucous membrane, dysbacteriosis, colon microflora, and intoxication. Signs of secondary immunodeficiency with simultaneous involvement of compensatory mechanisms of nonspecific and specific body defence were noted in the patients. More profound changes were revealed at the decompensated stage. Immunomodulating measures produce a normalizing effect on immunity indices and on the entire system of homeostasis.
Subject(s)
Constipation/immunology , Immune System/immunology , Adolescent , Adult , Aged , Blood Proteins/analysis , Chronic Disease , Combined Modality Therapy , Constipation/microbiology , Constipation/therapy , Female , Humans , Immunity, Cellular , Immunotherapy/methods , Intestine, Large/microbiology , Male , Middle AgedSubject(s)
Adjuvants, Immunologic/administration & dosage , Arthritis, Juvenile/therapy , Peptides/administration & dosage , Thymus Extracts/administration & dosage , Adolescent , Antibody Formation/drug effects , Arthritis, Juvenile/immunology , Child , Child, Preschool , Chronic Disease , Combined Modality Therapy , Drug Evaluation , Humans , Immunity, Cellular/drug effects , Time FactorsABSTRACT
One hundred and seven sessions of hemosorption were performed on 77 patients with severe ulcerative colitis. Clinically, improvement was demonstrated in the reduction of the signs of intoxication in 50 to 60 per cent of patients. Combination of hemosorption and anti-inflammatory medication allowed to achieve a remission or a marked improvement determined by clinical observation or endoscopy of 39 from 52 patients with a severe, total form of the disease, whereas toxic influence of sulfasalazine was controlled and extra-intestinal complications were weakened in 8 patients from 11. Thirteen patients were operated upon due to inefficiency of therapy. Hemosorption contributed to reduction of content of protein molecules with mean molecular weight (61 per cent), phenol (73 per cent), and endotoxin of gram-negative bacteria (50 per cent). Dynamics of acute phase reactants and humoral immune factors testifies to a weak anti-inflammatory action of hemosorption. Reduced levels of plasma protein, albumin, potassium and cholesterol were corrected or spontaneously returned to normal.